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Pain General

P2X7-NLRP3-Caspase-1 signaling mediates activity-induced muscle pain in male but not female mice.

Mar 20, 2023

We developed an animal model of activity-induced muscle pain that is dependent on local macrophage activation and release of interleukin-1β (IL-1β). Activation of purinergic type 2X (P2X) 7 receptor...

Barriers and facilitators of evidence-based psychotherapies for chronic pain in adults: A systematic review.

Mar 20, 2023

Cognitive behavioral therapy (CBT), acceptance and commitment therapy (ACT), and mindfulness-based stress reduction (MBSR) have demonstrated effectiveness for improving outcomes in chronic pain. These...

[First Experience with Diaphragm Pacing System in the Czech Republic].

Mar 13, 2023

Patients with impaired diaphragm function are dependent on long-term mechanical ventilation. It is associated with numerous health complications as well as significant economic burden. Intramuscular d...

The utility of intraoperative neuromonitoring in pediatric surgical oncology.

Mar 13, 2023

Intraoperative nerve monitoring (IONM) is a technique used to decrease the possibility of nerve-associated morbidity and damage to nearby neural structures during complex surgical procedures. The use ...

Peripheral transient receptor potential vanilloid type 4 hypersensitivity contributes to chronic sickle cell disease pain.

Mar 13, 2023

Debilitating pain affects the lives of patients with sickle cell disease (SCD). Current pain treatment for patients with SCD fail to completely resolve acute or chronic SCD pain. Previous research ind...

CpG methylation levels in HPA axis genes predict chronic pain outcomes following trauma exposure.

Mar 13, 2023

Chronic posttraumatic musculoskeletal pain (CPTP) is a common outcome of traumatic stress exposure. Biological factors that influence the development of CPTP are poorly understood, though current evid...

Evaluating the impact of metabolic surgery on patients with prior opioid use.

Mar 06, 2023

Metabolic surgery is the most effective treatment for obesity and may improve obesity-related pain syndromes. However, the effect of surgery on the persistent use of opioids in patients with a history...

A cross-sectional study on the personality traits of episodic and chronic migraine patients.

Mar 06, 2023

Migraine, is a common neurological disorder that may be associated with certain personality traits. This study aims to identify and compare the personality traits accompanying the clinical and sociode...

"Time is on my side". Disease trajectory of vulvodynia: a systematic review with a narrative synthesis.

Mar 06, 2023

The aim of this systematic review was to shed light on the disease-trajectory of vulvodynia and identify potential risk factors which may affect such trajectory.We searched Pubmed to identify articles...

Assessing the Need for Transfer to a Trauma Center for Isolated Craniofacial Injury in a Rural State.

Mar 06, 2023

Management of craniofacial injuries typically defaults to plastic, ophthalmology, and oral maxillofacial surgeons which can challenge these surgical subspecialists' capacity to care for both trauma vi...

Epigenetic regulation of chemokine (CC-motif) ligand 2 in inflammatory diseases.

Mar 06, 2023

Appropriate responses to inflammation are conducive to pathogen elimination and tissue repair, while uncontrolled inflammatory reactions are likely to result in the damage of tissues. Chemokine (CC-mo...

[Screening of apoptosis-related differential proteins in rheumatoid arthritis patients with cold-dampness syndrome based on protein microarray technology].

Mar 06, 2023

Objective Screening the differentially expressed proteins related to apoptosis in cold-dampness syndrome of rheumatoid arthritis (RA). Methods Peripheral blood mononuclear cells (PBMCs) were collected...

Distress and resilience narratives within pain memories of adolescents and young adults with complex regional pain syndrome: A multi-method study.

Mar 06, 2023

A comprehensive understanding of pain memories requires consideration of risk and resilience factors across biopsychosocial domains. Previous research has typically focused on pain-related outcomes, l...

Mechanical and Heat Hyperalgesia upon Withdrawal from Chronic Intermittent Ethanol Vapor depends on Sex, Exposure Duration, and Blood Alcohol Concentration in Mice.

Mar 06, 2023

Approximately half of patients with alcohol use disorder report pain and this can be severe during withdrawal. Many questions remain regarding the importance of biological sex, alcohol exposure paradi...

Chronic Illness Patient Goals-of-Care Discussion Predictors

Feb 28, 2023

The following is a summary of the “Predictors of Documented Goals-of-Care Discussion for Hospitalized Patients With Chronic Illness,” published in the February 2023 issue of Pain and Symptom Manag...

Clinical differences in a multidisciplinary pediatric pain unit between primary and secondary chronic pain.

Feb 27, 2023

Chronic pain affects an important part of the pediatric population in developed countries. secondary chronic pain (SCP) can have a well-defined medical cause, but primary chronic pain (PCP) can have a...

Are catechol-O-methyltransferase gene polymorphisms genetic markers for pain sensitivity after all? - A review and meta-analysis.

Feb 27, 2023

The catechol-O-methyltransferase (COMT) gene has arguably been the designated pain sensitivity gene for nearly two decades. However, the literature provides inconsistent evidence. We performed several...

Dosimetric assessment of the mono and dual-isocentric VMAT technique based on flattening filter-free beams for SBRT with non-contiguous spinal targets.

Feb 27, 2023

The study aimed to evaluate the planning characteristics of spinal stereotactic body radiotherapy (SBRT) using mono- and dual-isocentric volumetrically modulated arc therapy (VMAT) techniques. The dos...

Spinal Cord Infarction With Prolonged Femoral Venoarterial Extracorporeal Membrane Oxygenation.

Feb 27, 2023

There have been sporadic reports of ischemic spinal cord injury (SCI) during venoarterial extracorporeal membrane oxygenation (VA-ECMO) support. The authors observed a troubling pattern of this catast...

The Efficacy of Acceptance and Commitment Therapy for Chronic Pain: A Systematic Review and Meta-analysis.

Feb 27, 2023

Previous meta-analyses of a small number of trials showed that acceptance and commitment therapy (ACT) might improve chronic pain. Many new trials have been published afterward, and the factors that m...

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