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Pain General

Peripheral nerve injury and sensitization underlie pain associated with oral cancer perineural invasion.

Jul 16, 2020

Cancer invading into nerves, termed perineural invasion (PNI), is associated with pain. Here we show that oral cancer patients with PNI report greater spontaneous pain and mechanical allodynia compare...

Offset analgesia identifies impaired endogenous pain modulation in pediatric chronic pain disorders.

Jul 16, 2020

Offset analgesia (OA), a psychophysical test of endogenous pain inhibition, is diminished in many adult chronic pain disorders but OA has not been investigated in youth with chronic pain disorders. Th...

30-day Readmissions and Reoperations after Total Elbow Arthroplasty: A National Database Study.

Jul 16, 2020

The purpose of this study was to determine the rate of short-term complications after TEA and identify predictors of readmission and reoperation. We hypothesized that TEA performed for acute elbow tra...

The state of the science in opioid policy research.

Jul 13, 2020

Characterize the state of the science in opioid policy research based on a literature review of opioid policy studies.We conducted a scoping review of studies evaluating the impact of U.S. state-level...

Substance use patterns and health profiles among US adults who use opioids, methamphetamine, or both, 2015-2018.

Jul 13, 2020

Methamphetamine use, with and without opioids, has increased substantially, but little is known about the sociodemographic characteristics, substance use patterns, or health profiles of individuals wh...

Hydrocephalus-related quality of life as assessed by children and their caregivers.

Jul 13, 2020

Hydrocephalus is a chronic medical condition that has a significant impact on children and their caregivers. The objective of this study was to measure the quality of life (QOL) of children with hydro...

Menstrual migraine among Spanish university students.

Jul 13, 2020

This study sought to determine the prevalence of menstrual migraine among female university students at the Nursing Faculty of Ciudad Real and to determine possible risk factors.A cross-sectional obse...

Cortical spreading depolarisation-induced facial hyperalgesia, photophobia and hypomotility are ameliorated by sumatriptan and olcegepant.

Jul 13, 2020

Cortical spreading depolarisation (CSD), the neural mechanism underlying migraine aura, may cause headache by sensitising the trigeminal system. Photophobia, the most bothersome accompanying symptom d...

Comorbid pain experiences in young women with dysmenorrhea.

Jul 13, 2020

The association among dysmenorrhea, chronic pain, and conditions classified as central sensitivity syndromes (CSS) is largely unknown. We investigated the co-occurrence of dysmenorrhea with chronic pa...

Ehlers-Danlos Syndrome and Hypermobility Syndrome Compared with Other Common Chronic Pain Diagnoses-A Study from the Swedish Quality Registry for Pain Rehabilitation.

Jul 13, 2020

Although chronic pain is common in patients with Ehlers-Danlos syndrome (EDS) and hypermobility syndromes (HMS), little is known about the clinical characteristics of these groups. The main aim was to...

Dual-Trajectories of Opioid and Gabapentinoid Use and Risk of Subsequent Drug Overdose among Medicare Beneficiaries in the United States: A Retrospective Cohort Study.

Jul 13, 2020

Little is known about opioid and gabapentinoid (OPI-GABA) use duration and dose patterns' associations with adverse outcomes risks. We examined associations between OPI-GABA dose and duration trajecto...

Limonene, a food additive, and its active metabolite perillyl alcohol improve regeneration and attenuate neuropathic pain after peripheral nerve injury: Evidence for IL-1β, TNF-α, GAP, NGF and ERK involvement.

Jul 13, 2020

Limonene (LIM) and its main metabolite perillyl alcohol (POH) are ingredients found in food with promising chemical entities due to their pharmacological profile. In this study, we hypothesized that L...

Anesthesia Management and Postanesthetic Recovery Following Endoscopic Sinus Surgery.

Jul 13, 2020

Delayed anesthesia recovery following endoscopic sinus surgery (ESS) can be an indicator of immediate complications and negatively impact healthcare efficiency. This study aims to examine clinical fac...

Post dural puncture headache evolving to a subdural hematoma: A case report.

Jul 13, 2020

Cervical epidural corticosteroid injections are frequently used for the treatment of subacute cervicobrachial pain. This therapy isconsidered safe with the vast majority of the complications being min...

Apoptosis and secondary necrosis of neutrophils and monocytes in the immunopathogenesis of rheumatoid arthritis: a cohort study.

Jul 13, 2020

Rheumatoid arthritis (RA) is a progressive chronic inflammatory and autoimmune joint disease. Neutrophils and monocytes are the main target cells of innate immune defense that modulate the course of i...

Understanding the relationship between features associated with pain-related disability in people with painful Temporomandibular Disorder (TMD): an exploratory structural equation modeling approach.

Jul 13, 2020

Pain-related disability is a multi-faceted construct that refers to the impact of pain on an individual's capacity to fulfill their self-defined and social roles. This research examined the relationsh...

Individuals with chronic pain have the same response to placebo analgesia as healthy controls in terms of magnitude and reproducibility.

Jul 13, 2020

It is unclear whether a diagnosis of chronic pain is associated with an increase or decrease in the placebo response. The aim of this study was to use an experimental placebo conditioning paradigm to ...

Uncovering the analgesic effects of a pH-dependent mu-opioid receptor agonist using a model of non-evoked ongoing pain.

Jul 13, 2020

Currently, opioids targeting mu-opioid receptors (MOR) are the most potent drugs for acute and cancer pain. However, opioids produce adverse side effects such as constipation, respiratory depression, ...

Prevalence of Haemophilus parasuis"Glaesserella parasuis" in pigs in China: A systematic review and meta-analysis.

Jul 13, 2020

Haemophilus parasuis, a gram-negative bacterium as an early commensal colonizer in the upper respiratory tract of weaning pigs (Sus scrofa), is one of the most important bacterial pathogens affecting ...

The Difference in Medial Meniscal Extrusion between Non-Weight-Bearing and Weight-Bearing Positions in People with and without Medial Compartment Knee Osteoarthritis.

Jul 13, 2020

Medial meniscal extrusion (MME) has been correlated with medial meniscal injury and progression of medial knee osteoarthritis (OA).Examine the difference in MME between non-weight-bearing (supine) and...

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