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Pain General

Incidence and Risk Factors for Implant Failure in Spinal Metastasis Surgery.

Jul 23, 2020

Retrospective study.To investigate the incidence of symptomatic and asymptomatic implant failure in spinal metastasis surgery and identify potential risk factors.Surgical stabilization with instrument...

Clinical Implication of Mid-Range Dynamic Instability in Lumbar Degenerative Spondylolisthesis.

Jul 23, 2020

Retrospective evaluation.To determine the prevalence of mid-range dynamic instability in patients with degenerative spondylolisthesis (DS) and to evaluate the clinical implication of mid-range instabi...

The Use of Cement in Hip Arthroplasty: A Contemporary Perspective.

Jul 23, 2020

Notable advances in hip arthroplasty implants and techniques over the past 60 years have yielded excellent survivorship of fully cemented, hybrid, and reverse hybrid total hip replacements as demonstr...

Mst1 promotes mitochondrial dysfunction and apoptosis in oxidative stress-induced rheumatoid arthritis synoviocytes.

Jul 23, 2020

In this study, we investigated the role of macrophage stimulating 1 (Mst1) and the AMPK-Sirt1 signaling pathway in the oxidative stress-induced mitochondrial dysfunction and apoptosis seen in rheumato...

Acceptance and Commitment Therapy for Primary Headache Sufferers: A Randomized Controlled Trial of Efficacy.

Jul 23, 2020

Prevention of headaches via avoidance of triggers remains the main behavioral treatment suggestion for headache management despite trigger avoidance resulting in increases in potency, lifestyle restri...

Is the Lipid Content of the Psoas Major Correlated with Chronic Low Back Pain and Spinopelvic Alignment? A Magnetic Resonance Spectroscopic Study.

Jul 23, 2020

Cross-sectional observational study.This study aimed to analyze any potential associations of extramyocellular lipid (EMCL) and intramyocellular lipid (IMCL) contents with (1) the intensity of low bac...

Pharmacokinetics and Safety of Mitragynine in Beagle Dogs.

Jul 23, 2020

Mitragynine is the most abundant psychoactive alkaloid derived from the leaves of (kratom), a tropical plant indigenous to regions of Southeast Asia. Mitragynine displays a moderate affinity to opioi...

Evaluation of serum uric levels in migraine.

Jul 23, 2020

In our study, the aim was to identify the serum uric acid levels, a marker of oxidative stress, according to migraine subtypes (aura/without aura and episodic/chronic migraine).The study included 300 ...

Low-dose methadone for refractory chronic migraine accompanied by medication-overuse headache: a prospective cohort study.

Jul 23, 2020

A refractory chronic migraine (RCM) accompanied by medication-overuse headache (MOH) is an extremely disabling disease. Evidence suggests that in selected patients, chronic opioids may be a valuable t...

Unusual Brain MRI Findings in Patients Imaged for Headache: a Case Series.

Jul 23, 2020

We describe a series of cases with unusual brain MRI findings in patients who present with headache disorders.Incidental findings in patients imaged for headache include the following: aneurysm, arach...

Relevance of Mitochondrial Dysfunction in the Reserpine-Induced Experimental Fibromyalgia Model.

Jul 23, 2020

Fibromyalgia (FM) is one of the most common musculoskeletal pain conditions. Although the aetiology of FM is still unknown, mitochondrial dysfunction and the overproduction of reactive oxygen intermed...

Meniscal Allograft Transplantation After Anterior Cruciate Ligament Reconstruction Can Improve Knee Stability: A Comparison of Medial and Lateral Procedures.

Jul 23, 2020

The purpose of this study was to evaluate the clinical score and stability after meniscal allograft transplantation (MAT) after a previous anterior cruciate ligament (ACL) reconstruction.Medial MAT wo...

Pharmacologic interventions for prevention of delirium in hospitalized older people: A meta-analysis.

Jul 20, 2020

To comprehensively assess the effects of pharmacologic interventions for prevention of delirium in hospitalized older people.A systematic review with meta-analysis following Preferred Reporting Items ...

A Phase I, Randomized, Single‑Blind, Placebo‑Controlled, Single Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of Subcutaneous and Oral TRV250, a G Protein-Selective Delta Receptor Agonist, in Healthy Subjects.

Jul 20, 2020

The delta opioid receptor (DOR) has been identified as a therapeutic target for migraine, with DOR agonists exhibiting low abuse potential compared with conventional µ-opioid agonists. TRV250 is a no...

Effect of Headache-Free Days on Disability, Productivity, Quality of Life, and Costs Among Individuals with Migraine.

Jul 20, 2020

The functional impairment associated with migraine can cause physical, emotional, and economic ramifications that can affect occupational, academic, social, and family life. Understanding the relation...

Burden of Illness Among People with Migraine and ≥ 4 Monthly Headache Days While Using Acute and/or Preventive Prescription Medications for Migraine.

Jul 20, 2020

Migraine is a chronic disease that reduces health-related quality of life. Little is known about the burden of migraine in individuals who are potential candidates for preventive treatment with ≥ 4 ...

Validity of fibromyalgia survey questionnaire (2016) assessed by telephone interview and cross-cultural adaptation to Brazilian Portuguese language.

Jul 20, 2020

To verify the validity of the 2016-revised Fibromyalgia Survey Questionnaire (FSQ) by telephone interview compared to self-administration and to produce a valid version of FSQ in Brazilian Portuguese ...

Spectrochemical analysis in blood plasma combined with subsequent chemometrics for fibromyalgia detection.

Jul 20, 2020

Fibromyalgia is a rheumatologic condition characterized by multiple and chronic body pain, and other typical symptoms such as intense fatigue, anxiety and depression. It is a very complex disease wher...

The Effects of Antepartum Depressive Symptoms on Postcesarean Opioid Consumption.

Jul 20, 2020

 The study aimed to test the hypothesis that higher Edinburgh Postnatal Depression Scale (EPDS) scores are associated with increased pain scores and opioid use during postpartum hospitalization foll...

Study of Double-Targeting Nanoparticles Loaded With MCL-1 siRNA and Dexamethasone for Adjuvant-induced Arthritis Therapy.

Jul 20, 2020

The co-delivery of nanoparticles encapsulating gene therapies and chemotherapeutic drugs can achieve synergistic treatment and reduce side effects in normal tissues relative to the systemic use of sin...

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