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Pain General

Genus Gentiana: A review on phytochemistry, pharmacology and molecular mechanism.

Sep 17, 2020

As the largest genus of Gentianaceae family, the Gentiana genus harbors over 400 species, widely distributed in the alpine areas of temperate regions worldwide. Plants from Gentiana genus are traditio...

The clinical effectiveness of intensive management in moderate established rheumatoid arthritis: The titrate trial.

Sep 17, 2020

Many trials have shown that intensive management is effective in patients with early active rheumatoid arthritis (RA). But its benefits are unproven for the large number of RA patients seen in routine...

Evaluation of a personally-tailored opioid overdose prevention education and naloxone distribution intervention to promote harm reduction and treatment readiness in individuals actively using illicit opioids.

Sep 14, 2020

Opioid overdose prevention education and naloxone distribution (OEND) programs include information on general risk factors, overdose recognition, and naloxone utilization. This study evaluated a perso...

Profiling the Extent and Location of Pain in Migraine and Cervicogenic Headache: A Cross-sectional Single-Site Observational Study.

Sep 14, 2020

The primary aim was to quantify and compare the location and extent of pain in people with either episodic migraine, chronic migraine, or cervicogenic headache. A secondary aim was to examine the asso...

Transcranial Doppler Evaluation of the Cerebral Vasculature in Women Patients who Have Migraine with Aura.

Sep 14, 2020

Previous studies suggest that increased cerebrovascular reactivity might be a feature of patients who have migraine with aura (MwA). The correlation between the clinical presentation of migraine with ...

Patterns of Perceived Stress Throughout the Migraine Cycle: A Longitudinal Cohort Study Using Daily Prospective Diary Data.

Sep 14, 2020

To describe patterns of perceived stress across stages of the migraine cycle, within and between individuals and migraine episodes as defined for this study.Individuals with migraine aged ≥18 years...

An electromyography-assisted biomechanical cervical spine model: Model development and validation.

Sep 14, 2020

In spite of the prevalence of occupational neck disorders as a result of work force fluctuating from industry to sedentary office work, most cervical spine computational models are not capable of simu...

Endogenous theta stimulation during meditation predicts reduced opioid dosing following treatment with mindfulness-oriented recovery enhancement.

Sep 14, 2020

Veterans experience chronic pain at greater rates than the rest of society and are more likely to receive long-term opioid therapy (LTOT), which, at high doses, is theorized to induce maladaptive neur...

Effect of canakinumab on clinical and biochemical parameters in acute gouty arthritis: a meta-analysis.

Sep 14, 2020

Targeted anti-IL-1β therapy may be a valuable option for the management of gouty arthritis. The present meta-analysis has evaluated the effect of canakinumab, an anti-IL-1β monoclonal antibody in go...

COPA syndrome, 5 years after: where are we?

Sep 14, 2020

Heterozygous missense mutations in COPA, encoding coatomer protein subunit alpha (COPA), cause an interferonopathy mainly associating lung, joint and kidney involvement. This rare autoinflammatory dis...

Low back pain and the social determinants of health: a systematic review and narrative synthesis.

Sep 14, 2020

The social determinants of health (SDH) are known to differentially impact outcomes from many noncommunicable diseases; however, their potential role in low back pain (LBP) is poorly defined. This rev...

An experimental investigation into the mediating role of pain-related fear in boosting nocebo hyperalgesia.

Sep 14, 2020

Nocebo hyperalgesia refers to increases in perceived pain that putatively result from negative expectations regarding a nocebo stimulus (eg, an inert treatment, compared with no treatment). The precis...

Assessing the validity of health administrative data compared to population health survey data for the measurement of low back pain.

Sep 14, 2020

Low back pain (LBP) is a high-burden condition that lacks routine surveillance data. Health administrative data may be used for surveillance, but their validity for measuring LBP in the general popula...

Abdominal muscle activity and pelvic motion according to active straight leg raising test results in adults with and without chronic low back pain.

Sep 14, 2020

Active Straight Leg Raise (ASLR) is a clinical test that challenges lumbopelvic stability and have been used in low back pain patients. There are reports of positive tests in asymptomatic individuals,...

Activation of acid-sensing ion channel 3 by lysophosphatidylcholine 16:0 mediates psychological stress-induced fibromyalgia-like pain.

Sep 14, 2020

Fibromyalgia is commonly considered a stress-related chronic pain disorder, and daily stressors are known triggers. However, the relation between stress and pain development remains poorly defined by ...

The prevalence and impact of comorbidities on patients with axial spondyloarthritis: results from a nationwide population-based study.

Sep 14, 2020

In contrast to other chronic rheumatic musculoskeletal diseases such as rheumatoid arthritis, comorbidities in axial spondyloarthritis (axSpA) and their impact on disease outcomes are less well studie...

Influence of ESR1 variants on clinical characteristics and fibromyalgia syndrome in Turkish women.

Sep 14, 2020

Fibromyalgia syndrome (FMS) is characterized by widespread musculoskeletal pain. It is more common in women than in men, and sex hormones may play a role in this predominance. Therefore, this research...

Interleukin-15 in autoimmunity.

Sep 14, 2020

Interleukin-15 (IL-15) is a member of the IL-2 family of cytokines, which use receptor complexes containing the common gamma (γ) chain for signaling. IL-15 plays important roles in innate and adaptat...

Impact of polysubstance use on high-sensitivity cardiac troponin I over time in homeless and unstably housed women.

Sep 14, 2020

The use of controlled substances like cocaine increases the risk of cardiovascular disease (CVD) and myocardial infarction (MI). However, outside of alcohol and tobacco, substance use is not included ...

Early Supervised Physiotherapy and Recovery from Acute Ankle Sprain

Sep 11, 2020

Ankle sprains are one of the most common types of musculoskeletal injuries. Physiotherapy is routinely given to patients with ankle sprains. This study aims to evaluate the efficacy of supervised phys...

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