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Pain General

Pain Responses to Protease-Activated Receptor-2 Stimulation in the Spinal Cord of Naïve and Arthritic Rats.

Sep 21, 2020

There is strong evidence showing that the activation of peripheral proteinase-activated receptors type 2 (PAR-2) can initiate hyperalgesic and inflammatory responses in the joint. However, to date, th...

A risk score for postoperative nausea and/or vomiting in women undergoing cesarean delivery with intrathecal morphine.

Sep 21, 2020

Postoperative nausea/vomiting affects up to 80% of parturients undergoing cesarean delivery, but there is a lack of obstetric-specific risk-prediction models. We performed this study to identify posto...

A Multifaceted Approach to Opioid Education, Prescribing, and Disposal for Patients with Breast Cancer Undergoing Surgery.

Sep 17, 2020

Standardized prescribing practices are recommended to decrease opioid abuse, however, data regarding the handling and disposal of leftover narcotics are lacking. This quality improvement project and a...

Development and validation of a clinical prediction score for poor postoperative pain control following elective spine surgery.

Sep 17, 2020

Thirty percent to sixty-four percent of patients experience poorly controlled pain following spine surgery, leading to patient dissatisfaction and poor outcomes. Identification of at-risk patients bef...

Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial.

Sep 17, 2020

Observational studies have shown a link between zinc deficiency and migraine headaches. We aimed to examine the effect of zinc supplementation on the characteristics of migraine attacks in patients wi...

Efficacy of patent foramen ovale closure for treating migraine: a prospective follow-up study.

Sep 17, 2020

This study aims to evaluate the potential of percutaneous patent foramen ovale (PFO) closure to improve the headache in patients with migraine and PFO, and discuss the difference between the randomize...

Validity and Intrarater Reliability Using a Smartphone Clinometer Application to Measure Active Cervical Range of Motion Including Rotation Measurements in Supine.

Sep 17, 2020

Technological advances have given smartphones the capabilities of sensitive clinical measurement equipment at lesser cost and higher availability. The Clinometer is a smartphone application that can b...

Association between FokI polymorphism of Vitamin D Receptor gene and lumbar spine disc degeneration: A systematic review and meta-analysis.

Sep 17, 2020

The aim of the present meta-analysis was to explore the association between FokI polymorphism of the VDR gene and lumbar spine disc degeneration.The search was performed in PubMed, Scopus and Web of S...

Effect of Perioperative Active Body Surface Warming Systems on Analgesic and Clinical Outcomes: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Sep 17, 2020

Inadvertent perioperative hypothermia is a common complication of surgery, and active body surface warming (ABSW) systems are used to prevent adverse clinical outcomes. Prior data on certain outcomes ...

Effectiveness of Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial.

Sep 17, 2020

Current pharmacologic therapies for patients with osteoarthritis are suboptimal.To determine the efficacy of extract (CL) for reducing knee symptoms and effusion-synovitis in patients with symptomati...

Transcranial direct current stimulation accelerates the onset of exercise-induced hypoalgesia: a randomised controlled study.

Sep 17, 2020

Exercise-induced hypoalgesia (EIH) describes acute reductions in pain that occur following exercise. Current evidence suggests that the magnitude of EIH is small-to-moderate at best, warranting explor...

Changes in patient functioning and disability: results from a phase 3, double-blind, randomized, placebo-controlled clinical trial evaluating galcanezumab for chronic migraine prevention (REGAIN).

Sep 17, 2020

To evaluate secondary outcomes including changes in functioning and disability associated with galcanezumab, a humanized monoclonal antibody to calcitonin gene-related peptide, in patients with chroni...

Patient Perception of Depressive Symptoms in Rheumatic Diseases: A Cross-sectional Survey.

Sep 17, 2020

The presented study aimed to explore the presence and the self-identification of depressive symptoms among patients with rheumatic musculoskeletal diseases (RMDs) through the use of the Patient Health...

Neural effects of placebo analgesia in fibromyalgia patients and healthy individuals.

Sep 17, 2020

Placebo analgesia is hypothesized to involve top-down engagement of prefrontal regions that access endogenous pain inhibiting opioid pathways. Fibromyalgia (FM) patients have neuroanatomical and neuro...

Identifying biopsychosocial factors that impact decompressive laminectomy outcomes in veterans with lumbar spinal stenosis: a prospective cohort study.

Sep 17, 2020

One in three patients with lumbar spinal stenosis (LSS) undergoing decompressive laminectomy (DL) to alleviate neurogenic claudication do not experience substantial improvement. This prospective cohor...

Incidence and case fatality rate of COVID-19 in patients with inflammatory articular diseases.

Sep 17, 2020

To describe the incidence and fatality of COVID-19 and identify risk factors to fatality in patients with inflammatory articular diseases (IAD).This is a cross-sectional observational study of IAD pat...

Genus Gentiana: A review on phytochemistry, pharmacology and molecular mechanism.

Sep 17, 2020

As the largest genus of Gentianaceae family, the Gentiana genus harbors over 400 species, widely distributed in the alpine areas of temperate regions worldwide. Plants from Gentiana genus are traditio...

The clinical effectiveness of intensive management in moderate established rheumatoid arthritis: The titrate trial.

Sep 17, 2020

Many trials have shown that intensive management is effective in patients with early active rheumatoid arthritis (RA). But its benefits are unproven for the large number of RA patients seen in routine...

Evaluation of a personally-tailored opioid overdose prevention education and naloxone distribution intervention to promote harm reduction and treatment readiness in individuals actively using illicit opioids.

Sep 14, 2020

Opioid overdose prevention education and naloxone distribution (OEND) programs include information on general risk factors, overdose recognition, and naloxone utilization. This study evaluated a perso...

Profiling the Extent and Location of Pain in Migraine and Cervicogenic Headache: A Cross-sectional Single-Site Observational Study.

Sep 14, 2020

The primary aim was to quantify and compare the location and extent of pain in people with either episodic migraine, chronic migraine, or cervicogenic headache. A secondary aim was to examine the asso...

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