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Pain General

Perioperative Pregabalin for Preventive Analgesia in Breast Cancer Surgery: A Meta-analysis of Randomized Controlled Trials.

Sep 24, 2020

Pregabalin is a drug for neuropathic pain. The antipronociceptive properties of pregabalin have led to its recent use as an adjuvant to the multimodal postoperative pain regimen. This meta-analysis wa...

High Prevalence of Falls Independent of Age in Adults Living with Chronic Pain.

Sep 24, 2020

High risks of falls have been reported in older adults with chronic pain but chronic pain similarly affects adults of all ages. This cross-sectional study aimed to determine the prevalence of falls an...

The Concept of Pain Inventory (COPI): Assessing a Child's Concept of Pain.

Sep 24, 2020

Clinical guidelines recommend that healthcare providers assist children to understand their experience of persistent pain, with pain science education a key component of clinical management in pediatr...

Impact of cognitive tasks on biomechanical and kinematic parameters of gait in women with fibromyalgia: a cross-sectional study.

Sep 24, 2020

Fibromyalgia (FM) is a chronic disease whose symptoms may cause altered walking pattern, which is important given the relevance of walking in daily life activities. These activities use to require the...

Walking disabilities are associated with tenosynovitis at the metatarsophalangeal joints: A longitudinal MRI-study in early arthritis.

Sep 24, 2020

The relationship between functional disability and MRI-inflammation has been studied for the hands, but has not been well established for the feet, even though walking-difficulties are common. Therefo...

Sunlight exposure, sun-protective behaviour, and anti-citrullinated protein antibody positivity: A general population-based study in Quebec, Canada.

Sep 24, 2020

To examine associations between sunlight exposure and anti-citrullinated protein antibodies (ACPA) using general population data in Quebec, Canada.A random sample of 7600 individuals (including 786 po...

Ubiquitination in rheumatoid arthritis.

Sep 24, 2020

Rheumatoid arthritis is a chronic, inflammatory joint disease leading to inflammation of synovial membrane that lines the joints. This inflammation further progresses and results in destruction of joi...

Functional impairment and disability among patients with migraine: evaluation of galcanezumab in a long-term, open-label study.

Sep 21, 2020

Migraine can negatively impact patient functioning and quality of life. Here, we report the effects of galcanezumab (GMB), a humanized monoclonal antibody that binds to calcitonin gene-related peptide...

Effect of Migraine on Pregnancy Planning: Insights From the American Registry for Migraine Research.

Sep 21, 2020

To evaluate the effect of migraine on women's pregnancy plans.Participants were enrolled in the American Registry for Migraine Research, an observational study that recruits patients from headache spe...

Motivations to initiate injectable hydromorphone and diacetylmorphine treatment: A qualitative study of patient experiences in Vancouver, Canada.

Sep 21, 2020

Within the context of the ongoing overdose crisis and limitations of conventional opioid treatments, the scale-up of injectable hydromorphone (HDM) and diacetylmorphine (DAM) as evidenced-based treatm...

Individual and social network correlates of recent treatment for substance use disorders among persons who use drugs in Baltimore, MD (2014 - 2017).

Sep 21, 2020

This analysis examined individual and network correlates of treatment enrollment for substance use disorders (SUDs) in the past 6 months and whether these factors varied by type(s) of drug(s) used and...

A Systematic Review of Arthroscopic Versus Open Debridement of the Arthritic Elbow.

Sep 21, 2020

To systematically review the available data with regard to clinical and functional outcomes of arthroscopic and open debridement for elbow arthritis in order to determine the complication rate with tr...

Patients' perceptions of the pathways linking chronic pain with problematic substance use.

Sep 21, 2020

Approximately one-half of patients with substance use disorders (SUD) experience chronic pain. Yet how patients perceive the relationship between their substance use and chronic pain remains poorly un...

Optimized acupuncture treatment (acupuncture and intradermal needling) for cervical spondylosis-related neck pain: a multicenter randomized controlled trial.

Sep 21, 2020

Cervical spondylosis (CS)-related neck pain is difficult to treat due to its degenerative nature. The aim of this nine-center, single-blinded, randomized controlled trial was to evaluate the efficacy ...

Neuropathic pain: clinical classification and assessment in patients with pain due to cancer.

Sep 21, 2020

Neuropathic cancer pain (NcP) is associated with worse treatment responses and specific therapy indications, but a standardized clinical diagnosis of NcP is still lacking.This is a prospective observa...

Safety and efficacy of galcanezumab in patients for whom previous migraine preventive medication from two to four categories had failed (CONQUER): a multicentre, randomised, double-blind, placebo-controlled, phase 3b trial.

Sep 21, 2020

Many patients who require migraine preventive treatment have not been able to tolerate or have not responded to multiple previous preventive medications. We aimed to assess the safety and efficacy of ...

MiR103a-3p and miR107 are related to adaptive coping in a cluster of fibromyalgia patients.

Sep 21, 2020

MicroRNA (miRNA) mainly inhibit post-transcriptional gene expression of specific targets and may modulate disease severity.We aimed to identify miRNA signatures distinguishing patient clusters with fi...

Comparison of patient-led, fibromyalgia-orientated physical activity and a non-specific, standardised 6-month physical activity program on quality of life in individuals with fibromyalgia: a protocol for a randomised controlled trial.

Sep 21, 2020

Exercise has been shown to significantly improve pain and function in individuals with fibromyalgia. Research into the effectiveness of exercise is often based on standardised exercise programmes that...

Fibromyalgia in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome: prevalence and screening.

Sep 21, 2020

To explore the prevalence, clinical characteristics, and screening strategy for fibromyalgia (FM) in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome.A total of 3...

PF-06410293: An Adalimumab Biosimilar.

Sep 21, 2020

PF-06410293 (Amsparity/Abrilada) is a biosimilar of the anti-tumor necrosis factor (TNF)-α antibody adalimumab. It is approved for use in all indications for which adalimumab is approved, including i...

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