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Pain General

Cognitive impairment in NMOSD-More questions than answers.

Oct 08, 2020

Neuromyelitis optica spectrum disorder (NMOSD) is a type of central nervous system antibody-mediated disease which affects mainly optic nerves and spinal cord, but may also present with acute brainste...

Involvement of the tuberomammillary nucleus of the hypothalamus in the modulation of nociception and joint edema in a model of monoarthritis.

Oct 08, 2020

Investigate the involvement of the histaminergic projections from tuberomammillary nucleus (TMN) to the spinal cord in the modulation of nociception and peripheral edema in a model of monoarthritis.Su...

Evolution of doctor shopping for oxycodone in the 67 million inhabitants in France as a proxy for potential misuse or abuse.

Oct 08, 2020

This nationwide study aimed to compare use of oxycodone and doctor shopping for oxycodone in 2010 and 2016, and to quantify doctor shopping for oxycodone by sex, age, formulation, and dosage in 2010 a...

Examination of the clinical factors associated with attendance at emergency departments for chronic pain management and the cost of treatment relative to that of other significant medical conditions.

Oct 08, 2020

Little is known about risk factors for emergency department (ED) attendance for chronic pain (CP) management and the relative service burden. We examined emergency department (ED) utilisation in patie...

Sex- and age-specific genetic analysis of chronic back pain.

Oct 08, 2020

Sex differences for chronic back pain (cBP) have been reported, with females usually exhibiting greater morbidity, severity and poorer response to treatment. Genetic factors acting in an age-specific ...

[Intestinal motility disorders in multimorbidity: between constipation and diarrhea].

Oct 08, 2020

 The Rome IV criteria for primary chronic obstipation help to distinguish between short-term ailments and a chronic pattern of complaints 1. In general, there are several causes of defecation disord...

New imidazopyridines with phosphodiesterase 4 and 7 inhibitory activity and their efficacy in animal models of inflammatory and autoimmune diseases.

Oct 08, 2020

Herein, we describe the rapid synthesis of a focused library of trisubstituted imidazo[4,5-b]pyridines and imidazo[4,5-c]pyridines from 2,4-dichloro-3-nitropyridine using the combination of solution-p...

Contemporary Population-Based Analysis of Bone Mineral Density Testing in Men Initiating Androgen Deprivation Therapy for Prostate Cancer.

Oct 08, 2020

Androgen deprivation therapy (ADT) is a cornerstone of treatment for advanced prostate cancer (PCa); however, it accelerates the loss of bone mineral density (BMD), which increases fracture risk. Guid...

Alternative Splicing of Opioid Receptor Genes Shows a Conserved Pattern for 6TM Receptor Variants.

Oct 05, 2020

The opioid receptor (OPR) family comprises the mu-, delta-, and kappa-opioid, and nociceptin receptors that belong to the superfamily of 7-transmembrane spanning G protein-coupled receptors (GPCRs). T...

Clinical and biobehavioral perspectives: Is medication overuse headache a behavior of dependence?

Oct 05, 2020

Medication overuse headache (MOH), previously known as analgesic abuse headache or medication misuse headaches, is a common form of chronic headache disorder that has a detrimental impact on health an...

Targeting the 5-HT and 5-HT receptors for acute migraine treatment.

Oct 05, 2020

Migraine is a common and highly disabling headache disorder associated with a substantial socioeconomic burden. Migraine treatments can be categorized as preventive treatment, aimed at reducing the fr...

An Evidence-Based Review of Galcanezumab for the Treatment of Migraine.

Oct 05, 2020

This is a comprehensive review of the current literature on the usage of galcanezumab for migraine treatment. It reviews the biology, pathophysiology, epidemiology, diagnosis, and conventional treatme...

3D-Printed Anatomic Modeling for Surgical Planning and Real-Time Operative Guidance in Complex Primary Spinal Column Tumors: Single-Center Experience and Case Series.

Oct 05, 2020

Three-dimensional (3D) printing has emerged as an available visualization tool for clinicians and patients. We sought to utilize patient-specific 3D-printed anatomical modeling for preoperative planni...

Prescription opioid misuse and its correlates among veterans and military in the United States: A systematic literature review.

Oct 05, 2020

Prescription opioid misuse (POM) has become a critical public health issue in the United States (US), with veteran and military population being especially vulnerable to POM. However, limited behavior...

Effect of a brief scenario-tailored educational program on parents' risk knowledge, perceptions and decisions to administer prescribed opioids: a randomized controlled trial.

Oct 05, 2020

This randomized, controlled trial evaluated whether a brief educational program (i.e., Scenario-Tailored Opioid Messaging Program [STOMP]) would improve parental opioid risk knowledge, perceptions, an...

An unusual complication of quadriparesis after trigger point injection: a case report.

Oct 05, 2020

Quadriparesis after intramuscular trigger point injections for myofascial pain syndrome has been rarely reported in the literature. A 37-year-old male patient presented with myofascial pain syndrome a...

Longitudinal and concurrent relationships between caregiver-child behaviours in the vaccination context and preschool attachment.

Oct 05, 2020

The present paper consists of two separate studies in which the overarching aim was to examine the relationships between caregiver-child behaviours in the vaccination context (infant and preschool) an...

Time-trends in Opioid Use Disorder Hospitalizations in Gout, Rheumatoid arthritis, Fibromyalgia, Osteoarthritis, and Low Back Pain.

Oct 05, 2020

To examine opioid use disorder (OUD)-related hospitalizations and associated healthcare utilization outcomes in people with five common musculoskeletal diseases.We used the U.S. National Inpatient Sam...

Impact of Multidomain Disease Presentations on Patients With Psoriatic Arthritis in the Corrona Psoriatic Arthritis/Spondyloarthritis Registry.

Oct 05, 2020

To compare disease characteristics, quality of life (QOL), and work productivity of patients with psoriatic arthritis (PsA) who had multidomain vs single-domain presentations.Adults with PsA enrolled ...

Factors Predictive of Prolonged Postoperative Narcotic Usage Following Orthopaedic Surgery.

Oct 05, 2020

The purpose of this comprehensive review was to investigate risk factors associated with prolonged opioid use after orthopaedic procedures. A comprehensive review of the opioid literature may help to ...

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