Oct 29, 2020

Persistent Idiopathic Facial Pain (PIFP) is a poorly understood chronic pain syndrome of the face, formerly known as atypical facial pain. It is characterized by a constant painful sensation without n...

Oct 29, 2020

Agonists to subtype C of the Mas-related G-protein-coupled receptors (MrgC) induce pain inhibition after intrathecal (i.t.) administration in rodent models of nerve injury. Here, we investigated wheth...

Oct 26, 2020

Multimodal pain management is the most effective way to treat postsurgical pain. However, the use of opioids for acute pain management has unfortunately been a significant contributor to the current...

Oct 26, 2020

Opioid use disorder (OUD) is characterized by heightened cognitive, physiological, and neural responses to opioid-related cues that are mediated by mesocorticolimbic brain pathways. Craving and withdr...

Oct 26, 2020

Complex regional pain syndrome (CRPS), formerly known as reflex sympathetic dystrophy (RSD), is a difficult to treat condition characterized by debilitating pain and limitations in functional ability....

Oct 26, 2020

In recent years, radiological and biochemical data has emerged regarding the development of cellular damage in the brain of patients with migraine, calling into question what has traditionally been ac...

Oct 26, 2020

Migraine is typically divided into 2 headache frequency denominated categories, episodic migraine (EM) and chronic migraine (CM). Characterizing more narrow headache day frequency groups may be of val...

Oct 26, 2020

Triptans, the most commonly prescribed acute treatments for migraine attacks are, per FDA labeling, contraindicated in cardiovascular (CV) disease patients and have warnings and precautions for those ...

Oct 26, 2020

Fibromyalgia (FM) is a chronic pain condition characterized by impaired emotional regulation. This study explored the brain response to pain-related fear as a potential brain signature of FM.We used a...

Oct 26, 2020

Current therapies for Juvenile Fibromyalgia (JFM), such as cognitive-behavioral therapy (CBT), improve pain coping but are less effective for pain reduction or engagement in physical activity. The Fib...

Oct 26, 2020

The phenotype of Spinal Muscular Atrophy (SMA) has been changing with the recent availability of three FDA-approved treatments: intrathecal Nusinersen, intravenous Onasemnogene abeparvovec-xioi and en...

Oct 26, 2020

Superficial siderosis of the central nervous system is a sporadic finding in magnetic resonance imaging, resulting from recurrent bleedings into the subarachnoid space. This study aimed to determine t...

Oct 26, 2020

The study of Patient-Controlled Analgesia (PCA) behaviors has led to greater understanding of factors that affect the pain experience. Although PCA behaviors can be influenced by cues to medication av...

Oct 26, 2020

Pathophysiologic mechanisms underpinning ongoing pain in whiplash associated disorder (WAD) are not well understood, however alterations in brain morphology and function have been observed in this pop...

Oct 26, 2020

Individuals with chronic pain conditions often report movement as exacerbating pain. An increasing number of researchers and clinicians have recognized the importance of measuring and distinguishing b...

Oct 26, 2020

Spinal injury is among the most severe and feared injuries an athlete may face. We present an up-to-date review of the recent literature, stratifying recommendations based on injury location (cervical...

Oct 26, 2020

In order to investigate efficacy of FGF21 combine dexamethasone (Dex) on rheumatoid arthritis (RA) meanwhile reduce side effects of dexamethasone. We used combination therapy (Dex 15 mg/kg + FGF21 0.2...

Oct 26, 2020

Direct reprogramming/direct conversion/transdifferentiation is a process that induces conversion between completely different matured (differentiated) cells in higher organisms. Unlike the process of ...

Oct 26, 2020

Rheumatoid arthritis (RA) is one of the most common chronic immune joint diseases, mainly involving blood vessels and small joints. The complex pathogenesis of RA greatly increases the difficulty of t...

Oct 22, 2020

To assess the association between migraine and cryptogenic ischemic stroke (CIS) in young adults, with subgroup analyses stratified by sex and presence of patent foramen ovale (PFO).We prospectively e...