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Pain General

Demand curve analysis of marijuana use among persons living with HIV.

Jan 18, 2021

Despite medicalization and legalization of marijuana use, factors influencing demand for marijuana among persons living with HIV (PLWH) are incompletely understood. This knowledge gap undermines effec...

Operative costs associated with arthroscopic assisted open reduction and internal fixation of acute ankle fractures.

Jan 18, 2021

Ankle fractures are a common orthopedic injury that frequently involves associated cartilage lesions, soft tissue damage, and a significant inflammatory burden. Despite studies revealing intra-articul...

Metformin and omega-3 fish oil elicit anti-inflammatory effects via modulation of some dysregulated micro RNAs expression and signaling pathways in experimental induced arthritis.

Jan 18, 2021

Rheumatoid arthritis is a progressive inflammatory disease with multiple dysfunctional intracellular signaling pathways that necessitate new approaches for its management. Hence, the study aimed to in...

Challenges of Combining Opioids and P2Y Inhibitors in Acute Coronary Syndrome: Should the Future Be Opioid Free?

Jan 18, 2021

Morphine has been long recognized as standard of care in the treatment of acute coronary syndrome (ACS) patients; however, its safety has recently been called into question due to a drug interaction w...

Death due to consumption of ibogaine: case report.

Jan 14, 2021

Ibogaine is a psychotropic indole alkaloid extracted from the roots of the Tabernanthe iboga shrub from the Apocynaceae family. Depending on the taken dose, it can lead to stimulant effects, euphoria,...

Emotional and Behavioral Trajectories of 2 to 9 Years Old Children Born to Opioid-Dependent Mothers.

Jan 14, 2021

Maternal opioid use in pregnancy has increased dramatically. Knowledge about children's longer-term emotional and behavioral development after prenatal opioid exposure is scarce. A regional sample of ...

Headache Characteristics and Psychological Factors Associated with Functional Impairment in Individuals with Persistent Posttraumatic Headache.

Jan 14, 2021

Persistent posttraumatic headache (PPTH), one of the most common symptoms following mild traumatic brain injury, is often associated with substantial functional disability. The objective of this study...

Headache characteristics and burden from chronic migraine with medication overuse headache: Cross-sectional observations from the Medication Overuse Treatment Strategy trial.

Jan 14, 2021

To describe headache characteristics, medication use, disability, and quality of life in a large patient cohort from the United States who have chronic migraine (CM) and medication overuse headache (M...

Management of primary headaches during pregnancy, postpartum, and breastfeeding: A systematic review.

Jan 14, 2021

Primary headaches (migraine, tension headache, cluster headache, and other trigeminal autonomic cephalgias) are common in pregnancy and postpartum. It is unclear how to best and most safely manage the...

Metal-induced oxidative stress level in patients with fibromyalgia syndrome and its contribution to the severity of the disease: A correlational study.

Jan 14, 2021

Fibromyalgia syndrome (FMS) is an extra-articular rheumatological disease characterised by widespread chronic musculoskeletal pain. Metal-induced oxidative stress contributes to the severity of FMS.Fi...

Chronic generalized pain disrupts whole brain functional connectivity in mice.

Jan 14, 2021

Fibromyalgia (FM) is a generalized chronic pain condition whose pathophysiology is poorly understood, and both basic and translational research are needed to advance the field. Here we used the Sluka ...

Prognostic factors of trochanteric bursitis in surgical-staged patients: a prospective study.

Jan 14, 2021

Trochanteric bursitis or greater trochanteric pain syndrome is a common disorder and frequent cause of lateral hip pain. It can lead to severe functional impairment with increase morbidity and poor qu...

Enhanced Recovery Pathway in Adult Patients Undergoing Thoracolumbar Deformity Surgery.

Jan 14, 2021

Enhanced recovery (ERAS) pathways can help hospitals maximize the incentives of bundled payment models while maintaining high-quality patient care. A key component of an enhanced recovery pathway is t...

Long-Term Rates of Bladder Dysfunction After Decompression in Patients with Cauda Equina Syndrome.

Jan 14, 2021

Cauda Equina Syndrome (CES) occurs due to compression of the lumbar and sacral nerve roots and is considered a surgical emergency. Although the condition is relatively rare, the associated morbidity c...

Down-regulation of AAR signaling by IL-6-induced GRK2 activation contributes to Th17 cell differentiation.

Jan 14, 2021

IL-6-triggered Th17 cell expansion is responsible for the pathogenesis of many immune diseases including rheumatoid arthritis (RA). Traditionally, IL-6 induces Th17 cell differentiation through JAK-ST...

Quantitative language features identify placebo responders in chronic back pain.

Jan 14, 2021

Although placebo effect sizes in clinical trials of chronic pain treatments have been increasing, it remains unknown if characteristics of individuals' thoughts or prior experiences can reliably infer...

Long-term inflammatory pain does not impact exploratory behavior and stress coping strategies in mice.

Jan 14, 2021

Pain puts patients at risk for developing psychiatric conditions such as anxiety and depression. Pre-clinical mouse models of pain-induced affective behavior vary widely in methodology and results, im...

Ultrasound-guided transversus abdominis plane block vs. trigger point injections for chronic abdominal wall pain: a randomized clinical trial.

Jan 14, 2021

The primary aim of this randomized clinical trial is to investigate the effects of ultrasound guided transversus abdominis plane (TAP) versus ultrasound guided trigger point injections (TPIs) on numer...

Low back pain among Italian runners: A cross-sectional survey.

Jan 14, 2021

Low Back Pain (LBP) is commonly reported as a very frequent disorder in sports, but its prevalence in runners remains unclear.To determine the prevalence of LBP in a wide sample of Italian runners.A c...

Pharmacokinetics of metformin in collagen-induced arthritis rats.

Jan 14, 2021

Due to the elevated presence of cytokines, the expressions of metabolic enzymes and drug transporters are altered in rheumatoid arthritis (RA). Given the high incidence of diabetes in patients with RA...

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