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Pain General

Expanding access to methadone treatment in Ohio through federally qualified health centers and a chain pharmacy: A geospatial modeling analysis.

Jan 28, 2021

In the United States, methadone provision for opioid use disorder (OUD) occurs at opioid treatment programs (OTPs). Ohio recently enacted a policy to expand methadone administration to Federally Quali...

Comparative Cost-Effectiveness of Tofacitinib With Continuing Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs for Active Rheumatoid Arthritis in South Korea.

Jan 28, 2021

The objective of this study was to evaluate the cost-effectiveness of initiating treatment with tofacitinib and subsequently incorporating it into a conventional synthetic disease-modifying anti-rheum...

The Quality of Online Resources Available to Patients Regarding Cannabidiol for Symptomatic Relief of Hip or Knee Arthritis is Poor.

Jan 28, 2021

This study aimed to assess the quality of online resources pertaining to cannabidiol (CBD) for the nonoperative management of hip and knee arthritis.Websites were identified on the three most popular ...

Potential applicability of cytokines as biomarkers of disease activity in rheumatoid arthritis: Enzyme-linked immunosorbent spot assay-based evaluation of TNF-α, IL-1β, IL-10 and IL-17A.

Jan 28, 2021

Biomarkers play a pivotal role in the management of rheumatoid arthritis (RA) by facilitating early diagnosis and 'treat to the target.' However, no gold standard biomarker has been identified for mon...

A proteome signature in dorsal root ganglia for acute incisional pain in mice.

Jan 28, 2021

After surgery, acute pain is still managed insufficiently and may lead to short- and long-term complications including chronic postsurgical pain and an increased prescription of opioids. Thus, identif...

Assessing outcome in postoperative pain trials: are we missing the point?A systematic review of pain-related outcome domains reported in studies early after total knee arthroplasty.

Jan 28, 2021

The management of acute postoperative pain remains suboptimal. Systematic reviews and Cochrane analysis can assist with collating evidence about treatment efficacy, but the results are limited in part...

A genome-wide screen reveals microRNAs in peripheral sensory neurons driving painful diabetic neuropathy.

Jan 28, 2021

Diabetes is a leading cause of peripheral neuropathy (diabetic peripheral neuropathy, DPN), and uncontrolled long-lasting hyperglycemia leads to severe complications. A major proportion of diabetics d...

Anxiety, Depression, & Chronic Pancreatitis

Jan 20, 2021

Psychiatric comorbidities are prevalent in patients with chronic pancreatitis (CP) and associated with pain and reduced quality of life (QOL), Anna Evans Phillips, MD, MS, explains. “Prior studies h...

Peripheral nerve injury promotes morphine-seeking behavior in rats during extinction.

Jan 18, 2021

Chronic neuropathic pain and prescription opioid abuse represent highly interconnected societal problems. We used a rat model of spared nerve injury (SNI) and an intravenous drug self-administration p...

Natural History and Conservative Treatment Options in Chiari Malformation Type I in Adults: A Literature Update.

Jan 18, 2021

Over the years, knowledge regarding the natural history of Chiari malformation type I (CM-I) has improved. However, there are still uncertainties in the literature regarding asymptomatic and oligosymp...

The Effect of Psychiatric Comorbidities on Headache-Related Disability in Migraine: Results From the Chronic Migraine Epidemiology and Outcomes (CaMEO) Study.

Jan 18, 2021

To examine the influences of depression and anxiety on headache-related disability in people with episodic migraine or chronic migraine.Depression and anxiety are common comorbidities in people with m...

The Efficacy of Vitamin D Supplementation for Migraine: A Meta-Analysis of Randomized Controlled Studies.

Jan 18, 2021

The efficacy of vitamin D for migraine remains controversial. We conduct a systematic review and meta-analysis to explore the influence of vitamin D versus placebo on treatment in migraine patients.We...

Relationship between Anxiety, Post-Traumatic Stress, Insomnia and Fibromyalgia among Female Refugees in Jordan: a Cross-Sectional Study.

Jan 18, 2021

Fibromyalgia (FM) is a syndrome of chronic widespread pain. While it has been studied in different populations and settings, the impact of FM and its associated psychological factors has not been prev...

Do women with vaginismus have a lower threshold of pain?

Jan 18, 2021

Vaginismus and dyspareunia are together categorized as a genito-pelvic pain and penetration disorder. We aimed to evaluate the threshold of pain and the pain sensitivity in women with vaginismus.In th...

Assessment of widespread and extra-articular pain in psoriatic arthritis: a case-control study.

Jan 18, 2021

A remarkable lack of detailed knowledge on pain areas in Psoriatic Arthritis (PsA) is present, and their clinical relevance is quite unknown. The main aim of the study was to explore pain areas in PsA...

Robot-assisted percutaneous vertebroplasty under local anesthesia for osteoporotic vertebral compression fractures: a retrospective, clinical, nonrandomized, controlled study.

Jan 18, 2021

A retrospective, clinical, nonrandomized, controlled study.To evaluate the application of a new spinal navigation robot on percutaneous vertebroplasty under local anesthesia.The result of inserting th...

Efficacy of novel bispecific antibody targeting TNF-α/CXCL10 in the treatment of experimental arthritis.

Jan 18, 2021

This study was aimed at generating and investigating the efficacy of a novel monoclonal bispecific antibody (BsAb) for the combined inhibition of tumor necrosis factor-α (TNF-α) and CXCL10 as a trea...

Brief preoperative mind-body therapies for total joint arthroplasty patients: a randomized controlled trial.

Jan 18, 2021

While knee and hip replacements are intended to relieve pain and improve function, up to 44% of knee replacement patients and 27% of hip replacement patients report persistent postoperative joint pain...

Mechanical sensitization, increased axonal excitability and spontaneous activity in C-nociceptors following UVB irradiation in pig skin.

Jan 18, 2021

UVB irradiation induces hyperalgesia in human and animal pain models. We investigated mechanical sensitization, increase in axonal excitability and spontaneous activity in different C-nociceptor class...

Projections from the lateral parabrachial nucleus to the lateral and ventral lateral periaqueductal gray subregions mediate the itching sensation.

Jan 18, 2021

Lateral and ventral lateral subregions of the periaqueductal gray (l/vlPAG) have been proved to be pivotal components in descending circuitry of itch processing, and their effects are related to the s...

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