Jan 28, 2021

Biomarkers play a pivotal role in the management of rheumatoid arthritis (RA) by facilitating early diagnosis and 'treat to the target.' However, no gold standard biomarker has been identified for mon...

Jan 28, 2021

After surgery, acute pain is still managed insufficiently and may lead to short- and long-term complications including chronic postsurgical pain and an increased prescription of opioids. Thus, identif...

Jan 28, 2021

The management of acute postoperative pain remains suboptimal. Systematic reviews and Cochrane analysis can assist with collating evidence about treatment efficacy, but the results are limited in part...

Jan 28, 2021

Diabetes is a leading cause of peripheral neuropathy (diabetic peripheral neuropathy, DPN), and uncontrolled long-lasting hyperglycemia leads to severe complications. A major proportion of diabetics d...

Jan 20, 2021

Psychiatric comorbidities are prevalent in patients with chronic pancreatitis (CP) and associated with pain and reduced quality of life (QOL), Anna Evans Phillips, MD, MS, explains. “Prior studies h...

Jan 18, 2021

Chronic neuropathic pain and prescription opioid abuse represent highly interconnected societal problems. We used a rat model of spared nerve injury (SNI) and an intravenous drug self-administration p...

Jan 18, 2021

Over the years, knowledge regarding the natural history of Chiari malformation type I (CM-I) has improved. However, there are still uncertainties in the literature regarding asymptomatic and oligosymp...

Jan 18, 2021

To examine the influences of depression and anxiety on headache-related disability in people with episodic migraine or chronic migraine.Depression and anxiety are common comorbidities in people with m...

Jan 18, 2021

The efficacy of vitamin D for migraine remains controversial. We conduct a systematic review and meta-analysis to explore the influence of vitamin D versus placebo on treatment in migraine patients.We...

Jan 18, 2021

Fibromyalgia (FM) is a syndrome of chronic widespread pain. While it has been studied in different populations and settings, the impact of FM and its associated psychological factors has not been prev...

Jan 18, 2021

Vaginismus and dyspareunia are together categorized as a genito-pelvic pain and penetration disorder. We aimed to evaluate the threshold of pain and the pain sensitivity in women with vaginismus.In th...

Jan 18, 2021

A remarkable lack of detailed knowledge on pain areas in Psoriatic Arthritis (PsA) is present, and their clinical relevance is quite unknown. The main aim of the study was to explore pain areas in PsA...

Jan 18, 2021

A retrospective, clinical, nonrandomized, controlled study.To evaluate the application of a new spinal navigation robot on percutaneous vertebroplasty under local anesthesia.The result of inserting th...

Jan 18, 2021

This study was aimed at generating and investigating the efficacy of a novel monoclonal bispecific antibody (BsAb) for the combined inhibition of tumor necrosis factor-α (TNF-α) and CXCL10 as a trea...

Jan 18, 2021

While knee and hip replacements are intended to relieve pain and improve function, up to 44% of knee replacement patients and 27% of hip replacement patients report persistent postoperative joint pain...

Jan 18, 2021

UVB irradiation induces hyperalgesia in human and animal pain models. We investigated mechanical sensitization, increase in axonal excitability and spontaneous activity in different C-nociceptor class...

Jan 18, 2021

Lateral and ventral lateral subregions of the periaqueductal gray (l/vlPAG) have been proved to be pivotal components in descending circuitry of itch processing, and their effects are related to the s...

Jan 18, 2021

Despite medicalization and legalization of marijuana use, factors influencing demand for marijuana among persons living with HIV (PLWH) are incompletely understood. This knowledge gap undermines effec...

Jan 18, 2021

Ankle fractures are a common orthopedic injury that frequently involves associated cartilage lesions, soft tissue damage, and a significant inflammatory burden. Despite studies revealing intra-articul...

Jan 18, 2021

Rheumatoid arthritis is a progressive inflammatory disease with multiple dysfunctional intracellular signaling pathways that necessitate new approaches for its management. Hence, the study aimed to in...