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Pain General

B lymphocytes, the gastrointestinal tract and autoimmunity.

Feb 22, 2021

Under homeostatic conditions, bidirectional interactions between the gastrointestinal and the immune system allow production of both inflammatory and anti-inflammatory responses designed to prevent un...

Synthesis and characterization of an injectable microparticles integrated hydrogel composite biomaterial: In-vivo biocompatibility and inflammatory arthritis treatment.

Feb 22, 2021

Polymeric hydrogels and microparticles have been widely used for localized drug delivery applications for the treatment of arthritis. Nonetheless, owing to initial burst drug release, non-specific bio...

The partial saphenous nerve injury model of pain impairs reward-related learning but not reward sensitivity or motivation.

Feb 22, 2021

Chronic pain is highly comorbid with affective disorders, including major depressive disorder. A core feature of major depressive disorder is a loss of interest in previously rewarding activities. Maj...

Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults With Knee Osteoarthritis: The START Randomized Clinical Trial.

Feb 22, 2021

Thigh muscle weakness is associated with knee discomfort and osteoarthritis disease progression. Little is known about the efficacy of high-intensity strength training in patients with knee osteoarthr...

Delta opioid receptor regulation of CGRP dynamics in the trigeminal complex.

Feb 22, 2021

Migraine is highly prevalent and is the sixth leading cause worldwide for years lost to disability. Therapeutic options specifically targeting migraine are limited, and delta opioid receptor (DOP) ago...

Risk Factors Associated With Transition From Acute to Chronic Low Back Pain in US Patients Seeking Primary Care.

Feb 18, 2021

Acute low back pain (LBP) is highly prevalent, with a presumed favorable prognosis; however, once chronic, LBP becomes a disabling and expensive condition. Acute to chronic LBP transition rates vary w...

Enriched environment and social isolation differentially modulate addiction-related behaviors in male offspring of morphine-addicted dams: the possible role of μ-opioid receptors and ΔFosB in the brain reward pathway.

Feb 18, 2021

Prenatal opioids exposure negatively affects the neurobehavioral abilities of children born from dependence dams. Adolescent housing conditions can buffer the detrimental impacts of early life experie...

Onabotulinumtoxin A Improves Psychological Aspects in Chronic Migraine Patients.

Feb 18, 2021

Chronic migraine (CM) affects 5.4% of the Kuwaiti population. It is associated with significant headache-related disability, psychiatric comorbidity and reduced quality of life. The aim of this study...

Enhanced Hemodynamic and Clinical Response to αCGRP in Migraine Patients-A TCD Study.

Feb 18, 2021

Sensitisation of the nervous system in a patient with migraine is supposed to be associated with calcitonin gene-related peptide (CGRP) activity. Therefore, the vascular response to human αCGRP (hα...

Real world effectiveness and tolerability of candesartan in the treatment of migraine: a retrospective cohort study.

Feb 18, 2021

To date, two randomized, controlled studies support the use of candesartan for migraine prophylaxis but with limited external validity. We aim to evaluate the effectiveness and tolerability of candesa...

Muscle activity and acute stress in fibromyalgia.

Feb 18, 2021

Fibromyalgia (FM) patients are likely to differ from healthy controls in muscle activity and in reactivity to experimental stress.We compared psychophysiological reactivity to cognitive stress between...

Numeric Rating Scales Show Prolonged Post-exertional Symptoms After Orthostatic Testing of Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Feb 18, 2021

Muscle pain, fatigue, and concentration problems are common among individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). These symptoms are commonly increased as part of the ph...

Trajectories of change in symptom severity in patients with fibromyalgia: exploratory analyses of a randomised controlled trial.

Feb 18, 2021

The clinical picture of fibromyalgia (FM) symptoms fluctuates, and the symptom severity varies within and between patients. The current study aimed to identify groups of PDS trajectories and to explor...

Inhibition of ERK1/2 Phosphorylation attenuates Spinal Cord Injury Induced Astrocyte Activation and Inflammation through Negatively regulating Aquaporin-4 in Rats.

Feb 18, 2021

The extracellular signal-regulated kinase (ERK) pathway has been reported to play a pivotal role in mediating spinal cord injury (SCI) progression. The present study aimed to investigate the effects o...

Meta-analysis of outcomes after intentional coverage of celiac artery in thoracic endovascular aortic repair.

Feb 18, 2021

The aim of this study was to demonstrate clinical outcomes of intentional coverage of celiac artery (CA) during thoracic endovascular aneurysm repair (TEVAR).MEDLINE, EMBASE, and Cochrane Library were...

Bisphosphonates in inflammatory rheumatic diseases.

Feb 18, 2021

The main well recognized action of bisphosphonates (BPs) is their antiresorptive capacity, making them first-line drugs in the treatment of osteoporosis and other metabolic bone diseases. In this revi...

[EBV-positive MTX-associated lymphoproliferative disorder and Ig M myeloma in rheumatoid arthritis].

Feb 18, 2021

 An 80-year-old female patient arrived with a pronounced lymphadenopathy and weight loss. 6 years ago she had been diagnosed with rheumatoid arthritis. At the time of arrival, she was administered M...

Relationship between psychological factors and spinal motor behaviour in low back pain: a systematic review and meta-analysis.

Feb 18, 2021

This meta-analysis investigated whether more negative psychological factors are associated with less spinal amplitude of movement and higher trunk muscle activity in individuals with low back pain. Fu...

The partial saphenous nerve injury model of pain impairs reward-related learning but not reward sensitivity or motivation.

Feb 18, 2021

Chronic pain is highly comorbid with affective disorders, including major depressive disorder. A core feature of major depressive disorder is a loss of interest in previously rewarding activities. Maj...

PAIN CATASTROPHIZING, OPIOID MISUSE, OPIOID USE, AND OPIOID DOSE IN PEOPLE WITH CHRONIC MUSCULOSKELETAL PAIN: A SYSTEMATIC REVIEW.

Feb 15, 2021

The objective of this study was to analyze the cross-sectional and longitudinal association between pain catastrophizing and opioid misuse, opioid use, and opioid dose in people with chronic musculosk...

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