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Pain General

Effect of Ventral vs Dorsal Spinal Surgery on Patient-Reported Physical Functioning in Patients With Cervical Spondylotic Myelopathy: A Randomized Clinical Trial.

Mar 11, 2021

Cervical spondylotic myelopathy is the most common cause of spinal cord dysfunction worldwide. It remains unknown whether a ventral or dorsal surgical approach provides the best results.To determine w...

Remote Measurement in Rheumatoid Arthritis: Qualitative Analysis of Patient Perspectives.

Mar 11, 2021

Rheumatoid arthritis (RA) is characterized by recurrent fluctuations in symptoms such as joint pain, swelling, and stiffness. Remote measurement technologies (RMTs) offer the opportunity to track symp...

Placebo and nocebo responses in randomized controlled trials of Janus kinase inhibitor monotherapy for rheumatoid arthritis : A meta-analysis.

Mar 11, 2021

The goal of this meta-analysis was to assess the frequency and magnitude of placebo and nocebo responses in placebo-controlled randomized controlled trials (RCTs) of Janus kinase (JAK) inhibitor monot...

Efficacy of a Combination of Conservative Therapies vs an Education Comparator on Clinical Outcomes in Thumb Base Osteoarthritis: A Randomized Clinical Trial.

Mar 11, 2021

A combination of conservative treatments is commonly used in clinical practice for thumb base osteoarthritis despite limited evidence for this approach.To determine the efficacy of a 6-week combinatio...

The anterior and traverse cage can provide optimal biomechanical performance for both traditional and percutaneous endoscopic transforaminal lumbar interbody fusion.

Mar 08, 2021

Transforaminal lumbar interbody fusion (TLIF) is a well-established surgical treatment for patients with lumbar degenerative disc disease; however, the optimal position for the interbody fusion cage i...

Efficacy and safety of EMA401 in peripheral neuropathic pain: results of two randomised, double-blind, phase 2 studies in patients with postherpetic neuralgia and painful diabetic neuropathy.

Mar 08, 2021

The analgesic efficacy and safety of two Phase 2b studies of EMA401 (a highly selective angiotensin II type 2 receptor antagonist), in patients with postherpetic neuralgia (PHN; EMPHENE) and painful d...

Vestibular drop attacks in Ménière's disease.

Mar 04, 2021

The aim of the present study was to evaluate the severity of vestibular drop attack (VDA) in Ménière's disease (MD) and to examine the association between VDA severity and other MD-related complaint...

Diagnosis and Treatment of Irritable Bowel Syndrome: A Review.

Mar 04, 2021

The prevalence of irritable bowel syndrome (IBS) in the United States is between 7% and 16%, most common in women and young people, with annual direct costs estimated at more than $1 billion dollars i...

Assessing Perioperative Multimodal Analgesia in Patients With Burns

Mar 03, 2021

Postoperative pain has been shown in prior research to be a major challenge for patients with burns who undergo autologous skin grafting. Burn injuries cause severe pain, with many patients requiring ...

Remote medulla ablongata ventral acute subarachnoid hemorrhage following cervical spinal surgery: A case report.

Mar 01, 2021

The incidence of remote intracranial hemorrhage (RICH) in patients during spinal surgery is rare and the detailed mechanism remains unclear.A 55-year-old man had undergone cervical discectomy and fusi...

Sex differences in US emergency department non-fatal visits for benzodiazepine poisonings in adolescents and young adults.

Mar 01, 2021

Benzodiazepine (BZD)-related overdose deaths have risen in the past decade and BZD misuse contributes to thousands of emergency department (ED) visits annually, with the highest rates in adolescents a...

Lipid metabolism in cartilage and its diseases: a concise review of the research progress.

Mar 01, 2021

The homeostasis of the vertebrate body depends on anabolic and catabolic activities that are closely linked the inside and outside of the cell. Lipid metabolism plays an essential role in these metabo...

Core outcome set for pediatric chronic pain clinical trials: results from a Delphi poll and consensus meeting.

Mar 01, 2021

Appropriate outcome measures and high-quality intervention trials are critical to advancing care for children with chronic pain. Our aim was to update a core outcome set for pediatric chronic pain int...

Factor structure and psychometric properties of the Connor-Davidson resilience scale (CD-RISC) in individuals with opioid use disorder.

Feb 25, 2021

Resilience is defined as the capacity for an individual to maintain normal functioning and resist the development of psychiatric disorders in response to stress and trauma. Although previous investiga...

Comparison of psychological symptoms and cognitive functions in patients under maintenance treatment with methadone or buprenorphine, current opioid users and healthy subjects.

Feb 25, 2021

Methadone and buprenorphine can affect the psychological symptoms and cognitive functioning of substance users. This study aimed to compare psychological symptoms and neuropsychological functioning in...

Brain glycogen metabolism: A possible link between sleep disturbances, headache and depression.

Feb 25, 2021

The functions of sleep and its links with neuropsychiatric diseases have long been questioned. Among the numerous hypotheses on sleep function, early studies proposed that sleep helps to replenish gly...

Treatment of headache disorders with acupuncture: a 6-year retrospective study.

Feb 25, 2021

Existing systematic reviews and meta-analyses indicate that acupuncture has similar clinical effectiveness in the prevention of headache disorders (HDs) as drug therapy, but with fewer side effects. A...

Anatomical variations of the foramen transversarium of cervical vertebrae from the ancient population of Herculaneum (79 CE; Naples, Italy).

Feb 25, 2021

Variations in the number, size and shape of the foramina transversaria of cervical vertebrae can affect the anatomical course of vital blood vessels and nerves, with the risk for pathological conditio...

Acupuncture Effects on Blood Parameters in Patients with Fibromyalgia.

Feb 25, 2021

Acupuncture reduces pain and symptoms significantly in fibromyalgia (FM). Currently, there are no laboratory markers to monitor treatment effectiveness. This study measured differences in biomarkers ...

Impact of isometric and concentric resistance exercise on pain and fatigue in fibromyalgia.

Feb 25, 2021

The aim of this study was to determine the local and systemic effects of isometric and concentric muscle contractions on experimental pain and performance fatigability in people with and without fibro...

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