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Pain General

PAD4 takes charge during neutrophil activation: impact of PAD4 mediated NET formation on immune-mediated disease.

Mar 29, 2021

Peptidyl arginine deiminase 4 (PAD4) is an enzyme expressed in neutrophils that, when activated, can drive the formation of neutrophil extracellular traps (NETs). Uncontrolled activation of PAD4 and s...

The responsiveness of quantitative sensory testing-derived sensory phenotype to disease-modifying intervention in patients with entrapment neuropathy: a longitudinal study.

Mar 29, 2021

The German Research Network on Neuropathic Pain (DFNS) quantitative sensory testing (QST) method for sensory phenotyping is used to stratify patients by mechanism associated sensory phenotype, theoris...

Classism in pain assessment and management: the mediating role of female patient dehumanization and perceived life hardship.

Mar 29, 2021

Compared to racism and sexism, classism in pain assessment and management practices (PAMP) has been less investigated and its mediating mechanisms are still unknown. Drawing upon a social psychologica...

Examining attentional biases, interpretation biases, and attentional control in people with and without chronic pain.

Mar 29, 2021

Psychological models of chronic pain (CP) highlight cognitive-processing biases (ie, attentional biases, interpretation biases, and attentional control) as pivotal processes that uniquely and synergis...

CDC's Efforts to Quantify Prescription Opioid Overdose Deaths Fall Short.

Mar 25, 2021

In a 2018 report titled, Quantifying the Epidemic of Prescription Opioid Overdose Deaths, four senior analysts of the Centers for Disease Control and Prevention (CDC), including the head of the Epidem...

Maternal continuous oral oxycodone self-administration alters pup affective/social communication but not spatial learning or sensory-motor function.

Mar 25, 2021

The broad use/misuse of prescription opioids during pregnancy has resulted in a surge of infants with Neonatal Opioid Withdrawal Syndrome (NOWS). Short-term irritability and neurological complications...

Opioid Overprescribing and Procedure-Specific Opioid Consumption Patterns for Plastic and Reconstructive Surgery Patients.

Mar 25, 2021

Opioid prescribing practices contribute to opioid misuse, dependency, and diversion. There are currently no comprehensive and quantitative evidence-based guidelines that give procedure-specific recomm...

Comparison of pregnenolone sulfate, pregnanolone and estradiol levels between patients with menstrually-related migraine and controls: an exploratory study.

Mar 25, 2021

Neurosteroids affect the balance between neuroexcitation and neuroinhibition but have been little studied in migraine. We compared the serum levels of pregnenolone sulfate, pregnanolone and estradiol ...

Headache - A Window to Dementia: An Unexpected Twist.

Mar 25, 2021

Migraine and other types of headaches have several symptoms associated with them. The association between migraine and dementia has been considered. It is a topic of discussion and appears to be multi...

Stroke-Like Migraine Attacks After Radiation Therapy (SMART) Syndrome: A Comprehensive Review.

Mar 25, 2021

SMART syndrome is a delayed complication of cranial irradiation that can be misconstrued as tumor recurrence or some other intracranial neurological disease. Recognition of this clinical syndrome is i...

Pain as a significant symptom in patients with Periodic Paralysis- A cross-sectional survey.

Mar 25, 2021

Pain as a significant symptom in patients with Periodic Paralysis- A cross-sectional survey INTRODUCTION/AIMS: Periodic paralysis (PP) is thought to be limited to episodes of muscle weakness, however,...

Multidisciplinary rehabilitation treatments for patients with fibromyalgia: an international recent literature review.

Mar 25, 2021

Fibromyalgia (FM) is a pathology that causes physical, psychological, and social problems. For this reason, it requires treatment that involves all of these elements. The main of study is to examine m...

Hyperbaric oxygen treatment: Results in seven patients with severe bacterial postoperative central nervous system infections and refractory mucormycosis.

Mar 25, 2021

Resistant bacterial infections following brain and spine surgery and spontaneous mucormycosis with central nervous system (CNS) involvement represent a serious treatment challenge and more efficient t...

Spinal cord decompression sickness in an inside attendant after a standard hyperbaric oxygen treatment session.

Mar 25, 2021

Medical personnel in hyperbaric treatment centres are at occupational risk for decompression sickness (DCS) while attending patients inside the multiplace hyperbaric chamber (MHC). A 51-year-old male ...

Decompression sickness after a highly conservative dive in a diver with known persistent foramen ovale: Case report.

Mar 25, 2021

A diver returned to diving, 15 months after an episode of neuro-spinal decompression sickness (DCS) with relapse, after which she had been found to have a moderate to large provoked shunt across a per...

Paradoxical Psoriasis in Children Receiving Anti-TNFα Treatment for Inflammatory/autoimmune Disease.

Mar 25, 2021

Tumor necrosis factor alpha inhibitors (TNFi) are widely used in children with autoimmune and autoinflammatory conditions. Although TNFi are approved to treat psoriasis, they have also been shown to p...

Patient Perceptions of Psoriatic Arthritis Management and Communication with Physicians in Australia: Results from a Patient Survey.

Mar 25, 2021

The objective of this report was to evaluate perceptions of psoriatic arthritis (PsA) treatment and satisfaction with healthcare professional (HCP) communication among patients with PsA in Australia, ...

The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts.

Mar 25, 2021

Arthritis typically involves recurrence and progressive worsening at specific predilection sites, but the checkpoints between remission and persistence remain unknown. Here, we defined the molecular a...

The Value of Total Knee Replacement in Patients With Knee Osteoarthritis and a Body Mass Index of 40 kg/m or Greater : A Cost-Effectiveness Analysis.

Mar 25, 2021

Total knee replacement (TKR) is an effective and cost-effective strategy for treating end-stage knee osteoarthritis. Greater risk for complications among TKR recipients with a body mass index (BMI) of...

Assessing Prescription Opioid Medical Use & Misuse in Parents & Offspring

Mar 22, 2021

According to recent data, nearly 50% of adolescents who misuse prescription opioids report obtaining the drugs from relatives or friends. Understanding the parental origins of adolescent prescription ...

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