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Pain General

A thermal nociceptive patch in S2 cortex of nonhuman primates: a combined fMRI and electrophysiology study.

May 06, 2021

Human fMRI and behavioral studies have established the roles of cortical areas along the sylvian fissure in sensing subjective pain. Yet, little is known about how sensory aspects of painful informati...

Trans-Nasal High-Flow Dry Gas Reduces Migraine Pain

May 03, 2021

“Migraine headaches affect more than 12% of the United States population, mostly females, and result in significant impairment of quality of life and loss of productivity,” explains Rushil Shah, M...

RA and depression.

May 03, 2021

Depression constitutes the most frequent comorbid condition associated with rheumatoid arthritis (RA), with prevalence rates ranging from 14% to 48%. This wide range can be explain by several factors ...

US Case Reports of Cerebral Venous Sinus Thrombosis With Thrombocytopenia After Ad26.COV2.S Vaccination, March 2 to April 21, 2021.

May 03, 2021

Cerebral venous sinus thrombosis (CVST) with thrombocytopenia, a rare and serious condition, has been described in Europe following receipt of the ChAdOx1 nCoV-19 vaccine (Oxford/AstraZeneca), which u...

Update on pain in arthritis.

Apr 29, 2021

Osteoarthritis is a degenerative joint disease that features pain as a hallmark symptom. This review summarises progress and obstacles in our understanding of pain mechanisms in arthritis.Pain phenoty...

Association of chronic pain with comorbidities and health care utilization: a retrospective cohort study using health administrative data.

Apr 29, 2021

Health administrative data provide a potentially robust information source regarding the substantial burden chronic pain exerts on individuals and the health care system. This study aimed to use healt...

Comparative differences in musculoskeletal pain consultation and analgesic prescription for people with dementia: a UK-wide matched cohort study.

Apr 29, 2021

Painful musculoskeletal conditions are common in older adults; however, pain identification, assessment, and management are reported to be suboptimal for people with dementia. Adequate pain management...

Barriers and facilitators to older adults' use of nonpharmacologic approaches for chronic pain: a person-focused model.

Apr 29, 2021

In the context of the opioid epidemic and the growing population of older adults living with chronic pain, clinicians are increasingly recommending nonpharmacologic approaches to patients as complemen...

In Vivo electrophysiological mechanisms underlying cervical epidural stimulation in adult rats.

Apr 26, 2021

To electrophysiologically determine the predominant neural structures activated with cervical epidural stimulation (ES), well-established electrophysiological protocols (single-pulse, paired-pulse, an...

Efficacy and safety of pharmacological, physical, and psychological interventions for the management of chronic pain in children: a WHO systematic review and meta-analysis.

Apr 26, 2021

Chronic pain in childhood is an international public health problem. We conducted a systematic review and meta-analysis to provide a summary of the published evidence of pharmacological, physical, and...

Developing a Flexible National Wastewater Surveillance System for COVID-19 and Beyond.

Apr 22, 2021

Wastewater testing offers a cost-effective strategy for measuring population disease prevalence and health behaviors. For COVID-19, wastewater surveillance addresses testing gaps and provides an early...

Pain is the Primary Factor Associated with Satisfaction with Symptoms for New Patients Presenting to the Orthopaedic Clinic.

Apr 22, 2021

The purpose of the current study was to: (1) determine the percentage of new orthopaedic patients reporting their symptoms to be acceptable at presentation, as measured by the Patient Acceptable Sympt...

Single-position surgery versus lateral-then-prone-position circumferential lumbar interbody fusion: a systematic literature review.

Apr 22, 2021

to compare the outcomes of single position (SP) circumferential lumbar interbody fusion in lateral decubitus versus dual position (DP) fusion.A systematic literature review was performed in accordance...

Gender differences in activity-limiting pain trajectories over a 17-year period in the Mexican Health and Aging Study.

Apr 22, 2021

Pain increases with age, disproportionately affects women, and is a major contributor to decreased quality of life. Because pain is dynamic, trajectories are important to consider. Few studies have ex...

Spinal cord stimulation for the management of painful diabetic neuropathy: a systematic review and meta-analysis of individual patient and aggregate data.

Apr 22, 2021

Spinal cord stimulation (SCS) has been suggested as a treatment option for patients with painful diabetic neuropathy (PDN). We conducted a systematic review and undertook a meta-analysis on individual...

Effect of Poloxamer 188 vs Placebo on Painful Vaso-Occlusive Episodes in Children and Adults With Sickle Cell Disease: A Randomized Clinical Trial.

Apr 22, 2021

Although effective agents are available to prevent painful vaso-occlusive episodes of sickle cell disease (SCD), there are no disease-modifying therapies for ongoing painful vaso-occlusive episodes; t...

Enhanced Recovery after Surgery: Benefits for the Fetal Surgery Patient.

Apr 15, 2021

The fetoscopic approach to the prenatal closure of a neural tube defect (NTD) may offer similar advantages to the newborn compared to prenatal open closure of a NTD, with a reduction in maternal risks...

Longitudinal Opioid Surveillance Project Involving Toxicologic Analysis of Postmortem Specimens from 9 Counties in Michigan Suggests the Discovery of New High-Intensity Drug Trafficking Areas.

Apr 15, 2021

Acetyl fentanyl (AF) is a Schedule I fentanyl analog that has been increasingly seen in heroin and fentanyl polydrug toxicity overdoses in Michigan (MI). Drug users are often unaware of the presence o...

Efficacy of Adductor Canal Blocks in Total Knee Arthroplasty.

Apr 15, 2021

Total knee arthroplasty (TKA) is associated with significant postoperative pain. The population receiving TKA is generally elderly and often have multiple comorbidities that can present a challenge to...

The burden attributable to headache disorders in children and adolescents in Lithuania: estimates from a national schools-based study.

Apr 15, 2021

We recently showed headache to be common in children (aged 7-11 years) and adolescents (aged 12-17) in Lithuania. Here we provide evidence from the same study of the headache-attributable burden.Fol...

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