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Pain General

Role of Greater Occipital Nerve Block in Headache Disorders: A Narrative Review.

May 20, 2021

The proximity of sensory neurons in the upper cervical spinal cord to the trigeminal nucleus caudalis (TNC) neurons and the convergence of sensory input to TNC neurons from both cervical and trigemina...

Prevalence, burden of disease, and lost in health state utilities attributable to chronic musculoskeletal disorders and pain in Chile.

May 20, 2021

Musculoskeletal disorders are a leading cause of disability adjusted life years (DALY) in the world. We aim to describe the prevalence and to compare the DALYs and loss of health state utilities (LHSU...

Validating the revised Symptom Impact Questionnaire with a proposed fibromyalgia phenotype using experimentally-induced pain and patient self-reports.

May 20, 2021

The Symptom Impact Questionnaire (SIQR), now used for over a decade, has strong psychometric properties based on patients' subjective questionnaire data and correlations with other general measures of...

Fibromyalgia as a Heterogeneous Condition: Subgroups of Patients Based on Physical Symptoms and Cognitive-Affective Variables Related to Pain.

May 20, 2021

Fibromyalgia (FM) is a chronic syndrome characterized by heterogeneous clinical manifestations, and knowing this variability can help to develop tailored treatments. To understand better the heterogen...

Trunk and leg kinematics of grounded and aerial running in bipedal macaques.

May 20, 2021

Across a wide range of Froude speeds, non-human primates such as macaques prefer to use grounded and aerial running when locomoting bipedally. Both gaits are characterized by bouncing kinetics of the ...

A direct excitatory action of lactate ions in the central respiratory network.

May 20, 2021

Chemoreceptors that detect O2 and CO2/pH regulate ventilation. However, recent work shows that lactate ions activate arterial chemoreceptors independent of pH to stimulate breathing. Although lactate ...

Comparison of Functional and Radiological Outcomes of Transforaminal Lumbar Interbody Fusion and Posterolateral Fusion Techniques in the Treatment of Lumbar Spinal Stenosis.

May 20, 2021

This study aimed to compare posterolateral fusion with transforaminal lumbar interbody fusion (PLF + TLIF) and PLF only in terms of revision surgery rates and complications, as well as functional and ...

"Precision Medicine in Autoimmune Diseases: Fact or Fiction".

May 20, 2021

Much is said about precision medicine, but its real significance and the possibility of making it a real possibility is far from certain. Several studies in each of the autoimmune diseases have provid...

A systematic review and network meta-analysis on the safety of early interventional treatments in rheumatoid arthritis.

May 20, 2021

To evaluate the safety of treatment strategies in patients with early rheumatoid arthritis (RA).Systematic searches of MEDLINE, EMBASE and PubMed were conducted up to September 2020. Double-blind rand...

Does Tocilizumab have a Role in Dermatology? A Review of Clinical Applications, its Adverse Side Effects and Practical Considerations.

May 20, 2021

Tocilizumab is a humanised monoclonal antibody to the interleukin-6 (IL-6) receptor which was first approved for use in refractory rheumatoid arthritis almost a decade ago. Since then, its use has exp...

Longitudinal, bidirectional relationships of insomnia symptoms and musculoskeletal pain across adolescence: the mediating role of mood.

May 20, 2021

Previous studies have established a bidirectional relationship between sleep and pain, and mood has been proposed as a mediator of this relationship. There are only a limited number of longitudinal st...

Risk factors for persistent pain after breast and thoracic surgeries: a systematic literature review and meta-analysis.

May 20, 2021

Persistent postsurgical pain (PPSP) is common after breast and thoracic surgeries. Understanding which risk factors consistently contribute to PPSP will allow clinicians to apply preventive strategies...

Relationship between gait complexity and pain attention in chronic low back pain.

May 20, 2021

Clinical models of chronic low back pain (cLBP) highlight the role of excessive attention to pain and kinesiophobia on the origin of disability. At the motor control level, various mechanisms are invo...

The Link Between Synovitis & Symptomatic Knee Osteoarthritis

May 19, 2021

“With an absence of effective, licensed disease-modifying treatments for OA, attention has turned to identifying clinically important targets for clinical trials,” explains Thomas Perry, PhD. “S...

Inverse OARSI-OMERACT Criteria Valid Gauge of Worsening KOA

May 17, 2021

“To address the growing focus on using patient-reported outcomes (PRO) and individual-specific outcomes when assessing osteoarthritis (OA), a strategy that defines clinically meaningful improvement ...

Efficacy and safety of jakinibs in rheumatoid arthritis: a systematic review and meta-analysis.

May 17, 2021

To assess the efficacy and safety of jakinibs for the treatment of active rheumatoid arthritis (RA) in patients with an inadequate response or intolerance to conventional synthetic or biologic disease...

Dorsal root ganglion stimulation of injured sensory neurons in rats rapidly eliminates their spontaneous activity and relieves spontaneous pain.

May 17, 2021

Dorsal root ganglion field stimulation (GFS) relieves evoked and spontaneous neuropathic pain by use-dependent blockade of impulse trains through the sensory neuron T-junction, which becomes complete ...

Prevalence of chronic pain among adults in the United States.

May 17, 2021

Chronic pain is associated with reduced quality of life, increased medical expenditures, and significant economic costs. Chronic pain is among the most common chronic conditions in the United States, ...

Shedding light on pain for the clinic: a comprehensive review of using functional near-infrared spectroscopy to monitor its process in the brain.

May 17, 2021

Pain is a complex experience that involves sensation, emotion, and cognition. The subjectivity of the traditional pain measurement tools has expedited the interest in developing neuroimaging technique...

Knee Osteoarthritis: Personalizing Shared Decision Making

May 13, 2021

Shared decision making (SDM) in knee osteoarthritis (OA) is essential to optimizing patient-centered care and involves clinicians and patients collaborating to make decisions using the best available ...

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