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Pain General

Cortisol as a Marker of Pain and Distress Following Acute Musculoskeletal Trauma.

Jan 08, 2024

The best available predictors of chronic pain development broadly encompass baseline metrics of cognition (i.e. beliefs/expectations) about the trauma and resulting symptoms. In the context of musculo...

ELECTROPHYSIOLOGICAL ANALYSES OF HUMAN DORSAL ROOT GANGLIA AND HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED SENSORY NEURONS FROM MALE AND FEMALE DONORS.

Jan 01, 2024

Human induced pluripotent stem cell-derived sensory neurons (hiPSC-SNs) and human dorsal root ganglia neurons (hDRG-N) are popular tools in the field of pain research; however, few groups make use of ...

Athletes and Experimental Pain: A systematic review and meta-analysis.

Jan 01, 2024

The evidence that athletes respond to and report indices of experimental pain differently to non-athlete populations was analysed. Databases screened were SPORTDiscus, PubMED, PsycArticles, the Cochra...

Knockdown of Galectin-9 alleviates rheumatoid arthritis through suppressing TNF-α-induced activation of fibroblast-like synoviocytes.

Dec 25, 2023

The role of Galectin-9 (Gal-9) in the pathogenesis of rheumatoid arthritis (RA) remains unclear. This study aimed to investigate the mechanism of action and therapeutic potential of Gal-9 in RA. We de...

Childhood trauma and the use of opioids and other prescription analgesics in adolescence and young adulthood. The HUNT Study.

Dec 25, 2023

Opioid and nonopioid analgesics are commonly prescribed to young people to alleviate pain. Even short-term prescriptions increase the risk of persistent use and future misuse of potent analgesics, suc...

Effect of exposure-based vs traditional cognitive behavior therapy for fibromyalgia: a two-site single-blind randomized controlled trial.

Dec 25, 2023

Fibromyalgia is a debilitating pain condition for which treatment effects are typically modest. The most evaluated psychological treatment is traditional cognitive behavior therapy (T-CBT), but promis...

Feature-based multimodal registration framework for vertebral pose estimation.

Dec 18, 2023

The reliable estimation of the vertebral body posture helps to aid a safe and effective spine surgery. The proposed work aims to present an MR to X-ray image registration to assess the 3D pose of the ...

Waiting in Pain II: An updated analysis of the multidisciplinary staffing levels and clinical activity in Australian specialist persistent pain services.

Dec 18, 2023

This study provides an update on multidisciplinary staffing and clinical activity in Australian specialist persistent pain services. Of the 109 services identified, 57 responded, met inclusion criteri...

Racial Differences in Movement-Related Appraisals and Pain Behaviors among Adults with Chronic Low Back Pain.

Dec 11, 2023

Research documents racial disparities in chronic low back pain (CLBP). Few studies have examined racial disparities in movement-related appraisals and no studies have examined anticipatory appraisals ...

Chronic pain among middle-aged and older adults in the United States: The role of everyday discrimination and racial/ethnic identity.

Dec 11, 2023

Chronic pain disproportionately affects middle-aged and older adults in the United States. Everyday discrimination is associated with worse pain outcomes and is more prevalent among adults from racial...

The effect of a six-week Aqua Pilates and Aqua Stretch intervention on pain, function, and quality of life in patients affected by ankylosing spondylitis: A rater-blind randomized controlled trial.

Nov 20, 2023

There has been a dearth of research into the benefits of water-based workouts for ankylosing spondylitis (AS) patients.This study aimed to compare the effect of Aqua Stretch and Aqua Pilates in improv...

Fluoroscopy-based robotic assistance for total hip arthroplasty improves acetabular cup placement accuracy for obese patients compared to the manual, fluoroscopic- assisted technique.

Nov 20, 2023

Patient obesity is a risk factor for poor acetabular cup positioning in total hip arthroplasty (THA).To assess the impact of using a novel, fluoroscopy-based robotic THA system on acetabular cup place...

The desire for side-effect information in pain treatment: an experimental analysis of contextual and individual difference factors.

Nov 20, 2023

Informing patients about potential side effects of pain treatment is a requirement that protects patients and aids decision making, but it increases the likelihood of unwanted nocebo side effects. If ...

Multimodal covarying brain patterns mediate genetic and psychological contributions to individual differences in pain sensitivity.

Nov 13, 2023

Individuals vary significantly in their pain sensitivity, with contributions from the brain, genes, and psychological factors. However, a multidimensional model integrating these factors is lacking du...

Alpha-7 Nicotinic Acetylcholine Receptor Activation Inhibits Trauma Induced Pronociceptive Autoimmune Responses.

Nov 13, 2023

Both autonomic nervous system dysfunction and immune system activation are characteristic of chronic pain after limb injuries. Cholinergic agonists reduce immune system activation in many settings. We...

Tofacitinib Efficacy in Patients with Rheumatoid Arthritis and Probable Depression/Anxiety: Post Hoc Analysis of Phase 3 and 3b/4 Randomized Controlled Trials.

Nov 06, 2023

The aim of our work is to assess the prevalence of probable major depressive disorder and/or probable generalized anxiety disorder (pMDD/pGAD) in patients with moderate to severe rheumatoid arthritis ...

Peripheral Pain Captured Centrally: Altered Brain Morphology on MRI in Small Fiber Neuropathy Patients With and Without an SCN9A Gene Variant.

Nov 06, 2023

The current study aims to characterize brain morphology of pain as reported by small fiber neuropathy (SFN) patients with or without a gain-of-function variant involving the SCN9A gene and compare the...

Efficacy of non-conventional synthetic DMARDs for patients with rheumatoid arthritis-associated interstitial lung disease: a systematic review and meta-analysis.

Oct 30, 2023

We conducted a systematic review and meta-analysis to determine the efficacy of non-conventional synthetic disease-modifying antirheumatic drug (ncs-DMARD) strategies on patients with rheumatoid arthr...

Benign or painful? The interpretation of pain and fear of progression in rheumatoid arthritis.

Oct 30, 2023

People with chronic pain tend to interpret ambiguous information as health-related, more so than people without. In this study, we aimed to investigate whether people with rheumatoid arthritis (RA) ex...

Deactivation of dorsal CA1 pyramidal neurons projecting to medial prefrontal cortex contributes to neuropathic pain and short-term memory impairment.

Oct 30, 2023

Neuropathic pain after peripheral nerve injury is a multidimensional experience that includes sensory, affective, and cognitive components that interact with one another. Hypoexcitation of the medial ...

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