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Pain General

Immersive interactive virtual walking reduces neuropathic pain in spinal cord injury: findings from a preliminary investigation of feasibility and clinical efficacy.

Aug 19, 2021

Chronic neuropathic pain (NP) is a common and often debilitating secondary condition for persons with spinal cord injury (SCI) and is minimally responsive to existing pharmacological and nonpharmacolo...

Tinnitus & Subjective Hearing Loss More Common in Migraine

Aug 17, 2021

“Tinnitus is a condition that affects approximately 10% of the adult population in the United States and can diminish one’s quality of life,” explains Hamid R. Djalilian, MD. “To date, there a...

Investigating a bidirectional relationship between overdose and provision of injection initiation assistance among persons who inject drugs in Vancouver, Canada and Tijuana, Mexico.

Aug 16, 2021

Individuals who initiate injection drug use often receive assistance from an injection-knowledgeable peer. Persons who assist peers in injection initiation events often inject frequently, which height...

A comprehensive UHPLC-MS/MS screening method for the analysis of 98 New Psychoactive Substances and related compounds in human hair.

Aug 16, 2021

In this study, a rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the targeted analysis of 98 New Psychoactive Substances (NPS) from the hair...

Development and feasibility of a soft pneumatic-robotic glove to assist impaired hand function in quadriplegia patients: A pilot study.

Aug 16, 2021

One of the common disorders in people with quadriplegia is having a weak grip strength that can affect activities of daily living (ADL). This study presents the design of a soft robotic glove via pneu...

Neurobiological antecedents of multisite pain in children.

Aug 16, 2021

Altered brain structure and function is evident in adults with multisite chronic pain. Although many such adults trace their pain back to childhood, it has been difficult to disentangle whether centra...

Trajectories of pregabalin use and their association with longitudinal changes in opioid and benzodiazepine use.

Aug 16, 2021

Concomitant use of pregabalin with opioids and/or benzodiazepines is common, despite the increased risks. However, clinical trials suggest pregabalin can have an opioid-sparing effect when treating ac...

Oxidative stress is associated with characteristic features of the dysfunctional chronic pain phenotype.

Aug 16, 2021

The Dysfunctional Chronic Pain (Dysfunctional CP) phenotype is an empirically-identifiable CP subtype with unclear pathophysiological mechanisms that cuts across specific medical CP diagnoses. This st...

Muscle Function & Composition Linked With Knee Pain Trajectory

Aug 12, 2021

“For most patients, pain control remains unsatisfactory,” explains Feng Pan, PhD, MMed, MBBS. “The few pharmacologic analgesic options available have limited efficacy and carry a substantial ris...

Molecular mechanism of hippocampal long-term potentiation - Towards multiscale understanding of learning and memory.

Aug 12, 2021

Long-term potentiation (LTP) of synaptic transmission is considered to be a cellular counterpart of learning and memory. Activation of postsynaptic NMDA type glutamate receptor (NMDA-R) induces traffi...

Inflammatory Response to Spinal Cord Injury and Its Treatment.

Aug 12, 2021

Spinal cord injury (SCI), as one of the intractable diseases in clinical medicine, is afflicting thousands of human beings, and the pathological changes after the injury have been a hot spot for explo...

Conditioned pain modulation is more efficient in painful than in non-painful diabetic polyneuropathy patients.

Aug 12, 2021

Endogenous pain modulation, as tested by the conditioned pain modulation (CPM) protocol, is typically less efficient in chronic pain patients compared to healthy controls. We aimed to assess whether C...

The Link Between Pain Experience & Discrimination

Aug 09, 2021

“Discrimination negatively influences health and well-being in the general population, but its impact on people with pain is unclear,” explains Ruth A. Hackett, PhD. “Therefore, it is important ...

Flower beverages of native medicinal plants from Argentina (Acacia caven, Geoffroea decorticans and Larrea divaricata) as antioxidant and anti-inflammatory.

Aug 09, 2021

Herbal beverages have been used as a natural part of the medicinal and food culture in northwestern Argentina. The flower beverages (infusion or decoction) of Acacia caven, Geoffroea decorticans and L...

Effectiveness of training physical therapists in pain neuroscience education for patients with chronic spine pain: cluster-randomized trial.

Aug 09, 2021

Chronic spinal pain poses complex challenges for healthcare around the world and is in need of effective interventions. Pain Neuroscience Education (PNE) is a promising intervention hypothesized to im...

Sensory Hypersensitivities in Migraine Significantly Impact Disability

Aug 08, 2021

“Migraine, which affects more than 1 billion people worldwide, is one of the leading causes of disability in people younger than 50,” says Keisuke Suzuki, MD, PhD. “In addition to moderate-to-se...

Penile Pain in Men With Peyronie’s Disease: Identifying Prevalence & Predictors

Aug 05, 2021

Men with Peyronie’s disease (PD) typically present with complaints of penile deformity, but some patients also report suffering from pain and erectile dysfunction (ED). “There is a common misconc...

Examining differences in prescription opioid use behaviors among U.S. adults with and without disabilities.

Aug 05, 2021

We aimed to identify differences in prescription opioid-related behaviors between adults with and without disabilities in the U.S. We analyzed data from the 2015-2017 National Survey on Drug Use and H...

Standardized Headache Therapy in the Pediatric Emergency Department Using Improvement Methodology.

Aug 05, 2021

Primary headache is a common cause of pediatric emergency department (PED) visits. Without published guidelines to direct treatment options, various strategies lacking evidence are often employed. Thi...

Oral cannabinoid preparations for the treatment of chronic migraine: a retrospective study.

Aug 05, 2021

To explore the effectiveness and safety of 3 oral cannabinoid preparations (FM2®, Bedrocan® and Bediol®) in the treatment of chronic migraine.Retrospective, cohort study.Patients with chronic migra...

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