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Pain General

Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain.

Jan 10, 2022

Heat shock protein 90 (Hsp90) is a ubiquitously expressed integral cellular protein essential for regulating proteomic stress. Previous research has shown that Hsp90 regulates critical signaling pathw...

The Management of Abdominal Evisceration in Tactical Combat Casualty Care: TCCC Guideline Change 20-02.

Jan 03, 2022

Historically, about 20% of hospitalized combat injured patients have an abdominal injury. Abdominal evisceration may be expected to complicate as many as one-third of battle-related abdominal wounds. ...

Adolescent pain: appraisal of the construct and trajectory prediction-by-symptom between age 12 and 17 years in a Canadian twin birth cohort.

Jan 03, 2022

Adolescent pain is common and continues into adulthood, leading to negative long-term outcomes including substance-related morbidity: an empirical definition of its construct may inform the early dete...

Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial.

Dec 27, 2021

Marine omega-3 fatty acid (omega-3) supplements have been used to treat depression but their ability to prevent depression in the general adult population is unknown.To test effects of omega-3 supplem...

Tracking Assessment Tool Supports Treatment of Opioid Use Disorder in Primary Care

Dec 21, 2021

Despite efforts to curb opioid use disorder (OUD), the epidemic continues to be a major national crisis. Methadone, buprenorphine, and naltrexone are standard of care FDA-approved treatments for OUD, ...

Surgical Causes of Significant Intraoperative Neuromonitoring Signal Changes in Three-Column Spinal Surgery.

Dec 20, 2021

Retrospective case series.To evaluate the risks and causes of neurologic complications in three-column spinal surgery by analyzing intraoperative neurophysiological monitoring (IONM) data.Three-column...

Effectiveness and safety of subcutaneous abatacept in biologic-naïve RA patients at Week 52: A Japanese multicentre investigational study (ORIGAMI study).

Dec 20, 2021

To evaluate the effectiveness and safety of abatacept over 52 weeks in biologic-naïve rheumatoid arthritis (RA) patients with moderate disease activity in the prospective, 5-year, observational stu...

Second messengers mediating high molecular weight hyaluronan-induced anti-hyperalgesia in rats with chemotherapy-induced peripheral neuropathy.

Dec 20, 2021

High molecular weight hyaluronan (HMWH) is an agonist at cluster of differentiation 44 (CD44), the cognate hyaluronan receptor, on nociceptors, where it acts to induce anti-hyperalgesia in preclinical...

Exercise combined with Acceptance and Commitment Therapy compared with a standalone supervised exercise programme for adults with chronic pain: a randomised controlled trial.

Dec 20, 2021

A prospective, 2-armed, parallel group randomised controlled trial (RCT) was conducted to compare the effectiveness of Acceptance and Commitment Therapy (ACT) combined with a supervised exercise progr...

Sesquiterpenes from Kadsura coccinea attenuate rheumatoid arthritis-related inflammation by inhibiting the NF-κB and JAK2/STAT3 signal pathways.

Nov 29, 2021

The roots of Kadsura coccinea is commonly used in Tujia ethnomedicine, named "heilaohu", having the effect of treating rheumatic arthritis (RA). Chemical investigation on the ethanol extract of heilao...

Common bacterial metabolite indole directly activates nociceptive neuron through TRPA1 channel.

Nov 29, 2021

Nociceptors are known to directly recognize bacterial cell wall components or secreted toxins, thereby leading to pain induced by bacterial infection. However, direct activation of nociceptors by bact...

The prevalence of chronic pain in young adults: a systematic review and meta-analysis.

Nov 29, 2021

Prior systematic reviews have summarized the prevalence and impact of chronic pain in "average" pediatric (i.e., school-age) and adult (i.e., middle-age) age groups. To our knowledge, this is the firs...

Toward rebalancing blood pressure instability after spinal cord injury with spinal cord electrical stimulation: A mini review and critique of the evolving literature.

Nov 22, 2021

High-level spinal cord injury commonly leads to blood pressure instability. This manifests clinically as orthostatic hypotension (OH), where blood pressure can drop to the point of loss of consciousne...

Validating the "Treatment Satisfaction Questionnaire for Medication" in Persian, and Evaluating Treatment Satisfaction Among Patients With Psoriasis.

Nov 22, 2021

Psoriasis is a dermatological condition often associated with systemic comorbidities such as arthritis. Because of the vital role of treatment compliance in improvement in patients' condition and the ...

Unique considerations for exercise programs to prevent future low back pain: the patient perspective.

Nov 22, 2021

There is moderate quality evidence that exercise can help prevent future low back pain (LBP). This study aimed to explore patient needs and preferences for exercise programs to prevent LBP, and the ou...

Canadian surveillance study of complex regional pain syndrome in children.

Nov 22, 2021

This study describes the minimum incidence of pediatric complex regional pain syndrome (CRPS), clinical features, and treatments recommended by pediatricians and pain clinics in Canada. Participants i...

[Analysis of upper airway structure development in children with different characteristics].

Nov 15, 2021

To analyze the development of upper airway in children with different characteristics. From June 2018 to June 2020, a total of 425 children younger than 16 years old who underwent head MRI examinati...

Multisystemic Therapy - Building Stronger Families (MST-BSF): Substance misuse, child neglect, and parenting outcomes from an 18-month randomized effectiveness trial.

Nov 08, 2021

Parental substance misuse impacts millions of children globally and is a major determinant of repeat maltreatment and out-of-home placement. There is little published research on family-based, compreh...

Peripheral GABAA receptor signaling contributes to visceral hypersensitivity in a mouse model of colitis.

Nov 08, 2021

Pain is a common and debilitating symptom of inflammatory bowel disease (IBD). Based on evidence that peripheral GABAA receptor (GAR) inhibition plays an important role in establishing colonic afferen...

Who are the placebo responders? A cross-sectional cohort study for psychological determinants.

Nov 08, 2021

A number of studies have demonstrated substantial individual differences in placebo effects. We aimed to identify individual psychological factors that potentially predicted the magnitude of placebo h...

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