Mar 14, 2022

Clinical research on social observational learning (SoL) as an underlying mechanism for inducing expectancy and eliciting analgesic placebo effects is lacking. This double-blinded randomized controlle...

Mar 07, 2022

Defined by dysfunction or degeneration of Aδ and C fibers, small fiber neuropathies (SFNs) entail a relevant health burden. In 50% of cases, the underlying cause cannot be identified or treated. In 1...

Mar 07, 2022

Opioids in general and remifentanil in particular can induce hyperalgesia. Preclinical data suggest that cannabidiol might have the capacity to reduce opioid-induced hyperalgesia (OIH). Thus, we inves...

Feb 28, 2022

Chronic pain has widespread, detrimental effects on the human nervous system. Its prevalence and burden increase with age. Machine learning techniques have been applied on brain images to produce stat...

Feb 21, 2022

Cefazolin (CFZ) is one of the most extensively used cephalosporins. This antibiotic exerts its bactericidal activity by interfering with bacterial cell wall formation, leading to bacteriolysis. CFZ is...

Feb 21, 2022

Galcanezumab, a monoclonal antibody against calcitonin gene-related peptide, is an emerging migraine preventative. We hypothesized that the preventive effects are conveyed via modulation of somatosens...

Feb 14, 2022

Due to current measurement, sizing and fitting approaches, poor bra fit is prevalent amongst larger breasted women. The impact of improving bra fit hasn't yet been explored. This pre-clinical study ai...

Feb 14, 2022

We aimed to determine the feasibility and efficacy of online strategies to recruit parents of children with pediatric rheumatic diseases (PRDs) for research and to evaluate the degree to which known f...

Feb 14, 2022

One folk use of Alstonia scholaris (L.) R. Br. in "Dai" ethno-medicine system is to treat gouty arthritis, which might be caused by hyperuricemia, but anti-hyperuricemic investigation of A. scholaris ...

Feb 07, 2022

Musculoskeletal pain is a global health concern and work-related psychosocial stress might be a potential contributing factor. This cross-sectional study investigates whether job stress is associated ...

Jan 31, 2022

L-arginine, a NO donor; Sodium hydrosulphide (NaHS), a hydrogen (H S) donor; Tricarbonyldichlororuthenium (II) dimer (CORM-2), CO donor are characterized as bioactive gas mediators that have been rese...

Jan 31, 2022

This study's objective was to investigate the efficacy and acceptability of intermittent aerobic exercise training on sleep parameters, fatigue, pain, depressive symptoms, physical function, and cardi...

Jan 31, 2022

Schnitzler syndrome is a rare disease of adult-onset with main features including chronic urticarial rash, recurrent fever, arthralgia or arthritis, monoclonal gammopathy of undetermined significance ...

Jan 31, 2022

Non-invasive vagus nerve stimulation (nVNS) is effective in several types of headache disorders. We sought to unravel the mechanism of how nVNS exhibits this efficacy. This study used a randomized, si...

Jan 31, 2022

Rheumatic diseases are often associated to debilitating chronic pain, which remains difficult to treat and requires new therapeutic strategies. We had previously identified lysophosphatidyl-choline (L...

Jan 24, 2022

Quantitative Magnetic Resonance Imaging (qMRI) is frequently used to map disease state and disease progression in lower extremity muscles of patients with Spinal Muscular Atrophy (SMA). This is in sta...

Jan 24, 2022

Chronic pain is a prevalent condition in youth, and the pain experience is strongly influenced by emotional processes. Studying emotion variability and regulation (ER) may help better understand pain ...

Jan 24, 2022

There is no clear understanding of the mechanisms causing persistent pain in patients with whiplash-associated disorder (WAD). The aim of this systematic review was to assess the evidence for nerve pa...

Jan 17, 2022

Lesbian, gay, and bisexual individuals ("sexual minorities" [SMs]) are overrepresented among individuals suffering from alcohol and other drug (AOD) problems. However, little is known regarding differ...

Jan 10, 2022

Studies comparing different drug treatments for chronic neuropathic pain (NP) are very limited. We, therefore, examined 4 recommended treatments, namely, antidepressants (duloxetine, venlafaxine, and ...