May 31, 2022

Active psychosocial therapies for chronic postsurgical pain have shown promise. Preoperatively disturbed (elevated depressed symptoms, anxious symptoms, or pain catastrophizing) and non-distressed par...

May 16, 2022

Health education is one of the main items to enable the promotion of health for individuals with fibromyalgia (FM) in Primary Health Care (PHC) in Brazil. The purpose of this study was to validate a m...

May 16, 2022

This is a retrospective cohort study.This study aims to determine the proportional incidence, clinical characteristics, treatment patterns with complications and changes in treatment of vertebral frac...

May 16, 2022

Off-label (OL) drug use is the prescription of a drug for indications other than those authorised in its technical datasheet. The objective of this study was to identify drugs recommended in rheumatol...

May 16, 2022

Ankle distraction arthroplasty and supramalleolar osteotomy were both options for post-traumatic varus ankle arthritis (VAA), but their comparative effectiveness was scarcely reported. This study aime...

May 16, 2022

Neuroimaging is a powerful tool to investigate potential associations between chronic pain and brain structure. However, the proliferation of studies across diverse chronic pain syndromes and heteroge...

May 09, 2022

Low-density lipoprotein receptor-related protein 4 (LRP4) plays a critical role in the central nervous system (CNS), including hippocampal synaptic plasticity, maintenance of excitatory synaptic trans...

May 09, 2022

Inflammatory arthritic diseases are characterized by a persistent inflammation of the synovial tissues where tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6) pro-inflammatory cytokines are...

May 09, 2022

Chronic pruritus is a prominent symptom of allergic contact dermatitis (ACD) and represent a huge unmet health problem. However, its underlying cellular and molecular mechanisms remain largely unexplo...

May 09, 2022

This phase III multicenter randomized double-blind placebo-controlled comparative study evaluated the efficacy and safety of diclofenac sodium patches for the treatment of cancer pain. The study consi...

May 02, 2022

Pediatric functional abdominal pain disorders (FAPD) are highly prevalent, difficult to diagnose, and challenging to treat. The brain systems supporting FAPD remain poorly understood. This investigati...

May 02, 2022

Animal and human studies have shown that exercise prior to nerve injury prevents later chronic pain, but the mechanisms of such preconditioning remain elusive. Given that exercise acutely increases fo...

Apr 28, 2022

Elderly patients' rehabilitation was significantly affected by postoperative discomfort. There was a lack of understanding about how to help older adults return to daily living following discharge. Th...

Apr 28, 2022

To evaluate the relationship between hypertension and knee discomfort severity in knee osteoarthritis (OA) patients. Cross-sectional analysis of OAI baseline data. Participants with knee OA (N=1,363) ...

Apr 28, 2022

To learn more about the characteristics of young people who use a specialized chronic non-cancer pain clinic and the therapies they receive and utilize. Over a six-month period, a retrospective chart ...

Apr 28, 2022

One of the most serious issues people face in coronary bypass was postoperative pain. The severity of pain after surgery hinders general activity, sleep, deep breathing, and sleep quality. The descrip...

Apr 28, 2022

Postoperatively distressed patients were more likely to develop chronic postsurgical pain. Psychological therapies, which are active, appear to be beneficial in reducing chronic postsurgical pain. The...

Apr 25, 2022

To determine the efficacy and safety, in terms of maternal and neonatal outcomes, of adding intrathecal midazolam to spinal anesthesia for cesarean delivery in healthy pregnant women.A meta-analysis o...

Apr 25, 2022

Chronic postsurgical pain (CPSP) is defined by pain intensity and pain-related functional interference. This study included measures of function in a composite score of patient-reported outcomes (PROs...

Apr 18, 2022

Ample data support a prominent role of peripheral T-type calcium channels 3.2 (CaV3.2) in generating pain states. Development of primary sensory neuron-specific inhibitors of CaV3.2 channels is an opp...