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Pain General

Proactive Pain Management May Cut Postop Opioid Prescriptions

Feb 03, 2020

MONDAY, Feb. 3, 2020 (HealthDay News) -- An enhanced recovery after surgery program complemented by a preemptive pain management program is associated with a decrease in opioid prescriptions at discha...

The Chronic Migraine Brain: What Have We Learned From Neuroimaging?

Jan 31, 2020

Chronic migraine is a highly disabling disease with a great impact on socioeconomic functioning and quality of life of migraine patients. Chronic migraine usually evolves from episodic migraine that g...

Prevalence of visual snow syndrome in the UK.

Jan 31, 2020

Visual snow syndrome is a recently described condition of unknown prevalence. We investigated the prevalence in a representative population sample from the UK and tested the hypothesis that visual sno...

Machine Learning Increases Diagnosticity in Psychometric Evaluation of Alexithymia in Fibromyalgia.

Jan 31, 2020

Here, we report an investigation on the accuracy of the Toronto Alexithymia Scale, a measure to assess alexithymia, a multidimensional construct often associate to fibromyalgia. Two groups of particip...

Is background methotrexate advantageous in extending TNF inhibitor drug survival in elderly patients with rheumatoid arthritis? An analysis of the British Society for Rheumatology Biologics Register.

Jan 31, 2020

To evaluate drug survival with monotherapy compared with combination therapy with MTX in RA older adults.Patients from the British Society for Rheumatology Biologics Register, a prospective observatio...

Validated LC-MS/MS method for quantitation of a selective JAK1 inhibitor, filgotinib in rat plasma and its application to a pharmacokinetic study in rats.

Jan 31, 2020

Filgotinib is a selective JAK1 (Janus kinase) inhibitor, filed in Japan for the treatment of rheumatoid arthritis. In this paper we are reporting a validated LC-MS/MS (liquid chromatography coupled wi...

Age of onset as an influencing factor for disease severity in children with familial Mediterranean fever.

Jan 31, 2020

To define the demographic, clinical and genetic features of familial Mediterranean fever (FMF) patients with early disease onset and to compare them with late-onset FMF patients. Patients were divide...

Conventional versus ultrasound treat to target: no difference in magnetic resonance imaging inflammation or joint damage over 2 years in early rheumatoid arthritis.

Jan 31, 2020

To investigate whether an ultrasound-guided treat-to-target strategy for early RA would lead to reduced MRI inflammation or less structural damage progression compared with a conventional treat-to-tar...

MyD88-dependent influx of monocytes and neutrophils impairs lymph node B cell responses to chikungunya virus infection via Irf5, Nos2 and Nox2.

Jan 31, 2020

Humoral immune responses initiate in the lymph node draining the site of viral infection (dLN). Some viruses subvert LN B cell activation; however, our knowledge of viral hindrance of B cell responses...

Association between MRI findings and patient-reported outcomes in patients with rheumatoid arthritis in clinical remission and at relapse.

Jan 30, 2020

To investigate whether magnetic resonance imaging (MRI) pathologies in the wrist/hand of rheumatoid arthritis (RA) patients are associated with patient-reported outcomes (PROs) at clinical remission a...

Mismatch between the impact of disease perceived by patients and the state of clinical remission assessed by physicians in psoriatic arthritis.

Jan 30, 2020

Both the evaluation of disease activity and the assessment of the impact of the disease on patients' lives are subjects of intense research at present in psoriatic arthritis (PsA). We aimed to test th...

Performance of the 2016 ACR/EULAR Sjögren's syndrome classification criteria in patients with secondary Sjögren's syndrome.

Jan 30, 2020

To evaluate the performance of the 2016 ACR-EULAR classification Sjögren's syndrome (SS) criteria for classifying patients with secondary SS.We randomly selected 300 patients with systemic lupus eryt...

Inhibition of glycogen synthase kinase-3β protects against collagen type II-induced arthritis associated with the inhibition of miR155/24 and inflammation and upregulation of apoptosis in rats.

Jan 30, 2020

MicroRNAs have been implicated in the pathogenesis of rheumatoid arthritis (RA) and their syntheses are modulated by glycogen synthase kinase-3β (GSK-3β). Therefore, we hypothesised that the GSK-3β...

The features and burden of headaches within a chiropractic clinical population: A cross-sectional analysis.

Jan 30, 2020

The aim of this study is to a) investigate the headache features and level of headache severity, chronicity, and disability found within a chiropractic patient population and b) to ascertain if patien...

Menstrual Migraine: What it is and Does it Matter?

Jan 30, 2020

The diagnostic criteria of menstrual migraine (MM), migraine related to menstruation and pure menstrual migraine, are placed in the appendix of the International Classification of Headache Disorders a...

Characterization of Ubrogepant

Jan 30, 2020

A growing body of evidence has implicated the calcitonin gene-related peptide (CGRP) receptors in migraine pathophysiology. With the recent approval of monoclonal antibodies targeting CGRP or the CGRP...

[The efficacy of the second generation triptan migrepam in the treatment of migraine attacks: results of the comparative study].

Jan 30, 2020

To evaluate the efficacy and safety of migrepam in the treatment of migraine attacks.Sixty patients with episodic migraine with and without aura, aged between 18 and 65 years, were included in the ran...

Intravenous Endothelin-1 Infusion Does Not Induce Aura or Headache in Migraine Patients With Aura.

Jan 30, 2020

To investigate whether intravenously infused provokes migraine aura and migraine headache in migraine patients with aura.Migraine with aura has been associated with endothelial dysfunction and increas...

Impact of Melatonin on Skeletal Muscle and Exercise

Jan 30, 2020

Skeletal muscle disorders are dramatically increasing with human aging with enormous sanitary costs and impact on the quality of life. Preventive and therapeutic tools to limit onset and progression o...

Sleep and Pain in Subjects with Fibromyalgia and Comorbid Insomnia: Double-blind, Crossover, Study of Suvorexant 20 mg versus Placebo.

Jan 30, 2020

The chronic pain disorder, fibromyalgia, is associated with sleep disturbance, typically sleep maintenance. No studies have evaluated the effect of sleep medication on pain sensitivity in this populat...

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