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Pain General

Prescription opioids and economic hardship in France.

Jan 30, 2023

This paper studies how opioid analgesic sales are empirically related to socioeconomic disparities in France, with a focus on poverty. This analysis is made possible using the OpenHealth database, whi...

Low-dose whole-spine imaging using slot-scan digital radiography: a phantom study.

Jan 30, 2023

Slot-scan digital radiography (SSDR) is equipped with detachable scatter grids and a variable copper filter. In this study, this function was used to obtain parameters for low-dose imaging for whole-s...

The burden of disease-specific multimorbidity among older adults in India and its states: evidence from LASI.

Jan 30, 2023

Around the world, advances in public health and changes in clinical interventions have resulted in increased life expectancy. Multimorbidity is becoming more of an issue, particularly in countries whe...

Modulation of the inflammatory response by pre-emptive administration of IMT504 reduces postoperative pain in rats and has opioid-sparing effects.

Jan 30, 2023

Despite the available knowledge on underlying mechanisms and the development of several therapeutic strategies, optimal management of postoperative pain remains challenging. This pre-clinical study hy...

"I Refused to Get Addicted to Opioids": Exploring Attitudes about Opioid Use Disorder in Patients with Advanced Cancer Pain and their Support People.

Jan 30, 2023

Patients with advanced cancer are commonly prescribed opioids, yet patient attitudes about opioid risks (e.g., opioid use disorder, or OUD) are understudied. Our objective was to use in-depth qualitat...

Outcome class imbalance and rare events: An underappreciated complication for overdose risk prediction modeling.

Jan 23, 2023

Low outcome prevalence, often observed with opioid-related outcomes, poses an underappreciated challenge to accurate predictive modeling. Outcome class imbalance, where non-events (i.e., negative clas...

Analysis of Risk Factors Related to the Efficacy of Foramen Ovale Closure as a Therapy for Migraine.

Jan 23, 2023

This study aimed to monitor the incidence of migraine non-remission after percutaneous patent foramen ovale (PFO) closure and to discuss relevant risk factors. Recently, evidence of a relationship bet...

Changes in the rest-activity rhythm in migraine patients are associated with anxiety symptoms.

Jan 23, 2023

To characterize rest-activity rhythm in chronic migraine (CM) and to investigate the relationship between this rhythm and depressive and anxiety symptoms in patients with CM.This was a study of adults...

Chronic non-cancer pain management - insights from Australian general practitioners: a qualitative descriptive study.

Jan 23, 2023

The study explored the experiences and perceptions of GPs regarding the management of chronic non-cancer pain (CNCP). Specifically, participants were asked to identify perceived enablers and barriers ...

Use of the Global Alignment and Proportion score to predict postoperative health-related quality of life in adult spinal deformity surgery.

Jan 23, 2023

The purpose of this study was to validate the Global Alignment and Proportion (GAP) score as a predictor of health-related quality of life (HRQOL) outcomes for patients undergoing adult spinal deformi...

Therapeutic effects of kefir peptides on adjuvant-induced arthritis in rats through anti-inflammation and downregulation of matrix metalloproteinases.

Jan 23, 2023

Rheumatoid arthritis (RA) is a chronic autoimmune disease. Its pathological features are synovial inflammation, bone erosion, and joint structural damages. Our previous studies have shown that kefir p...

Deep eutectic solvents-Hydrogels for the topical management of rheumatoid arthritis.

Jan 23, 2023

Deep eutectic solvents (DES) have demonstrated their ability to facilitate skin penetrability of rigid nanoparticles (NPs). Here, we reported a feasible and simple transdermal delivery strategy using ...

Optimized electrical stimulation of C-nociceptors in humans based on the chronaxie of porcine C-fibers.

Jan 23, 2023

Classically, to electrically excite C-nociceptors, rectangular pulses are used with a duration close to the estimated chronaxie of C-fibres (about 2 ms). Recent results using slow depolarizing stimuli...

Head and neck pain drawing area correlates with higher psychosocial burden but not with joint dysfunction in temporomandibular disorders: a cross-sectional study.

Jan 23, 2023

Head and neck pain drawings have been introduced as part of the diagnostic gold standard for temporomandibular disorders (TMD). We aimed to quantify the spatial extent of pain in TMD patients and to a...

A retrospective cohort study of cerebrovascular fibromuscular dysplasia.

Jan 16, 2023

Fibromuscular dysplasia (FMD) is a rare vasculopathy for which limited data are available particularly from Europe. Our aim was to study the clinical characteristics of a regional cohort of carotid fi...

Sleep and Sleep Complaints in Juvenile Fibromyalgia Syndrome.

Jan 16, 2023

To investigate sleep quality in juvenile fibromyalgia syndrome (JFS) and its impact on the global burden of the disease.Consecutive JFS patients who performed full-night polysomnography (PSG) were inc...

Comparative Safety Analysis of Opioid Agonist Treatment in Pregnant Women with Opioid Use Disorder: A Population-Based Study.

Jan 16, 2023

Receipt of opioid agonist treatment during early and late pregnancy for opioid use disorder may relate to varying perinatal risks. We aimed to assess the effect of time-varying prenatal exposure toÂ...

On-Site Therapeutic Drug Monitoring of Paracetamol Analgesic in Non-Invasively Collected Saliva for Personalized Medicine.

Jan 16, 2023

Paracetamol or acetaminophen is the main non-opioid analgesic recommended for mild pain by the World Health Organization (WHO) analgesic ladder. However, the high levels used of paracetamol are associ...

Uveitis in children: Epidemiological, clinical and prognostic characteristics.

Jan 16, 2023

The purpose of this study is to describe the characteristics and prognostic factors of pediatric uveitis in a French university referral hospital.We performed a retrospective study of all cases of all...

Nutritional status in rheumatoid arthritis.

Jan 16, 2023

Rheumatoid Arthritis (RA) is a chronic inflammatory autoimmune disease affecting the joints. It has been suggested that obesity increases the likelihood of RA development lowers the chance to achieve ...

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