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Pain General

Efficacy, Safety, and Acceptability of Pharmacologic Treatments for Pediatric Migraine Prophylaxis: A Systematic Review and Network Meta-analysis.

Feb 13, 2020

Migraine is one of the most common neurologic disorders in children and adolescents. However, a quantitative comparison of multiple preventive pharmacologic treatments in the pediatric population is l...

Different doses of galcanezumab versus placebo in patients with migraine and cluster headache: a meta-analysis of randomized controlled trials.

Feb 13, 2020

Galcanezumab is a novel monoclonal antibody that target to calcitonin gene-related peptide (CGRP). It has been tested for the preventive treatment of migraine and episodic cluster headache by multiple...

Reversible Lesion of the Corpus Callosum in a Patient With Migraine With Aura

Feb 13, 2020

To describe a patient with migraine with aura (MWA) who was found to have a reversible lesion of the corpus callosum.Reversible lesions of the splenium of the corpus callosum are well-described clin...

The relationship between exposure to hot/cold weather and the clinical features of headaches in patients with migraine and tension-type headaches.

Feb 13, 2020

: This study investigates the relationship between exposure to hot/cold weather and the characteristic clinical features of headaches in patients with migraine and tension-type headaches.: This cross-...

Positive and Negative Affect Schedule (PANAS): psychometric properties of the online Spanish version in a clinical sample with emotional disorders.

Feb 13, 2020

The Positive and Negative Affect Schedule (PANAS) is the most widely and frequently used scale to assess positive and negative affect. The PANAS has been validated in several languages, and it has sho...

Opioid Use in Fibromyalgia Continues Despite Guidelines That Do Not Support Its Efficacy or Risk

Feb 13, 2020

The aim of this cross-sectional study is to determine the prevalence of opioid use in a large sample of fibromyalgia (FM) patients and examine the factors associated with opioid prescription/use despi...

A review of the incidence and risk factors for fibromyalgia and chronic widespread pain in population-based studies.

Feb 13, 2020

This review identified prospective cohort studies in the general population which showed incidence (23 papers) and risk factors (37 papers) for fibromyalgia and chronic widespread pain. Median inciden...

Midterm Outcomes of Ultrasound-guided Local Treatment for Infrapatellar Saphenous Neuroma Following Total Knee Arthroplasty.

Feb 13, 2020

 While total knee arthroplasty (TKA) is a reliable treatment for advanced knee arthritis, up to 19% of patients after TKA remain dissatisfied, especially with residual pain. A less known source of me...

Neuroendocrine Effects of Naltrexone Versus Nalmefene

Feb 13, 2020

Naltrexone and nalmefene are approved for the treatment of alcohol use disorders, in different countries. Naltrexone is also approved for the treatment for opioid use disorders, most recently in a dep...

Quantitative proteomic analysis of the central amygdala in neuropathic pain model rats.

Feb 13, 2020

Pain and emotional distress have a reciprocal relation. The amygdala has been implicated in emotional processing. The central nucleus of amygdala (CeA) receives nociceptive information from the dorsal...

Estimating the impact of wide scale uptake of screening and medications for opioid use disorder in US prisons and jails.

Feb 13, 2020

Medications for opioid use disorder (OUD) are the most effective treatment for OUD, but uptake of these life-saving medications has been extremely limited in US prisons and jail settings, and limited ...

Trajectories of Retention in Opioid Agonist Therapy

Feb 13, 2020

Long-term engagement in opioid agonist therapy (OAT) has been consistently associated with reduced risk for morbidity and mortality in people with opioid use disorder (OUD). However, the dynamic natur...

The effect of saffron supplement on clinical outcomes and metabolic profiles in patients with active rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial.

Feb 13, 2020

Rheumatoid arthritis (RA) is a systemic autoimmune and inflammatory disease. Our study aimed to determine the effect of saffron supplement on clinical outcomes and metabolic profiles in patients with ...

Vitamin D in Autoimmune Bullous Disease

Feb 13, 2020

Numerous epidemiological studies have suggested a link between vitamin D deficiency and the development of various autoimmune diseases, including diabetes mellitus type 1, rheumatoid arthritis, inflam...

Psychosocial Factors Associated with Sleep Quality and Duration Among Older Adults with Chronic Pain.

Feb 13, 2020

Sleep complaints are common among older adults with chronic pain. Because of the risk of significant side effects, sleep medications are not recommended as first-line treatments. Little is known about...

Original Research: Arthritis-Related Functional Limitations and Inadequate Physical Activity Among Female Adult Cancer Survivors.

Feb 13, 2020

The American Cancer Society (ACS) Guidelines on Nutrition and Physical Activity for Cancer Prevention recommend an adequate level of physical activity for cancer prevention and survivorship. Many adul...

Immunomodulatory benefits of mesenchymal stem cells treated with Caffeine in adjuvant-induced arthritis.

Feb 13, 2020

We intend to assess the effect of the conditioned medium of Caffeine pulsed MSCS in the amelioration of rheumatoid arthritis (RA)-afflicted rats.MSCs were incubated with 0, 0.1, 0.5 or 1 mM Caffeine...

Effect of Incisional Negative Pressure Wound Therapy vs Standard Wound Dressing on Deep Surgical Site Infection After Surgery for Lower Limb Fractures Associated With Major Trauma: The WHIST Randomized Clinical Trial.

Feb 13, 2020

Following surgery to treat major trauma-related fractures, deep wound infection rates are high. It is not known if negative pressure wound therapy can reduce infection rates in this setting.To assess ...

Alterations in pronociceptive and antinociceptive mechanisms in patients with low back pain: a systematic review with meta-analysis.

Feb 13, 2020

Altered pronociceptive and antinociceptive mechanisms are often implicated in painful conditions and have been increasingly studied over the past decade. For some painful conditions, alterations are w...

Exploring the neural correlates of touch and pain in women with provoked vestibulodynia.

Feb 13, 2020

Group differences in touch and pain thresholds-and their neural correlates-were studied in women with provoked vestibulodynia (PVD; N = 15), a common subtype of vulvodynia (chronic vulvar pain), and p...

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