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Pain General

Learning mechanisms in nocebo hyperalgesia: the role of conditioning and extinction processes.

Mar 12, 2020

Nocebo hyperalgesia is a clinically relevant phenomenon and may be formed as a result of associative learning, implemented by classical conditioning. This study explored for the first time distinct no...

Individual variability and sex differences in conditioned pain modulation and the impact of resilience, and conditioning stimulus pain unpleasantness and salience.

Mar 12, 2020

Distinct pain experiences are shaped both by personal attributes and characteristics of noxious stimuli. An individual's capacity for endogenous pain inhibition (reflected by conditioned pain modulati...

Novel compound heterozygous pathogenic variants in ASCC1 in a Chinese patient with spinal muscular atrophy with congenital bone fractures 2 : Evidence supporting a "Definitive" gene-disease relationship.

Mar 12, 2020

A very limited spectrum of ASCC1 pathogenic variants had been reported in six (mostly consanguineous) families with spinal muscular atrophy with congenital bone fractures 2 [OMIM #616867] since 2016.A...

Fatal overdose prevention and experience with naloxone: A cross-sectional study from a community-based cohort of people who inject drugs in Baltimore, Maryland.

Mar 12, 2020

Overdose is a leading cause of death in the United States, especially among people who inject drugs (PWID). Improving naloxone access and carrying among PWID may offset recent increases in overdose mo...

Artificial neural network analysis of bone quality DXA parameters response to teriparatide in fractured osteoporotic patients.

Mar 12, 2020

Teriparatide is a bone-forming therapy for osteoporosis that increases bone quantity and texture, with uncertain action on bone geometry. No data are available regarding its influence on bone strain. ...

Stromal Cells in the Pathogenesis of Inflammatory Bowel Disease.

Mar 12, 2020

Up till now, research on inflammatory bowel disease [IBD] has mainly been focused on the immune cells present in the gastrointestinal tract. However, recent insights indicate that stromal cells also p...

Prevalence of extra-articular manifestations in psoriatic arthritis: a systematic review and meta-analysis.

Mar 12, 2020

To describe the prevalence of extra-articular manifestations-enthesitis, dactylitis, nail disease, uveitis and IBD-in PsA, and their impact on longitudinal disease outcomes.We searched Medline, PubMed...

Comparison of cannulated lag screws and lateral locking plate in the treatment of Schatzker type II tibial plateau fractures.

Mar 12, 2020

This study aims to compare the clinical and radiological outcomes of the two fixation methods frequently used in the treatment of Schatzker type II fractures: lag screw fixation and lateral anatomic p...

Can infection after anterior cruciate ligament surgery be prevented by inserting a Hemovac drain into graft donor site?

Mar 12, 2020

This study aims to investigate the effect of Hemovac drainage placed in graft harvesting area on preventing deep surgical site infection (SSI) and/or septic arthritis through draining the hematoma for...

Characterization of Cortisol Dysregulation in Fibromyalgia and Chronic Fatigue Syndromes: A State-Space Approach.

Mar 10, 2020

Fibromyalgia syndrome (FMS) and chronic fatigue syndrome (CFS) are complicated medical disorders, with little known etiologies. The purpose of this research is to characterize FMS and CFS by studying ...

Prenatal exposure to methadone or buprenorphine and long-term outcomes: A meta-analysis.

Mar 09, 2020

To combine meta-analyses of multiple long-term outcomes in children prenatally exposed to methadone or buprenorphine through their mothers' Opioid maintenance therapy (OMT) with a systematic review of...

Pain catastrophizing as a predictor of suicidal ideation in chronic pain patients with an opiate prescription.

Mar 09, 2020

Chronic pain and opioid use are associated with increased risk for suicidal ideation and behaviors (SIB) in cross-sectional studies, particularly among individuals who catastrophize about their pain. ...

Step-Headache: A Distinct Symptom of Migraine.

Mar 09, 2020

 The diagnosis of migraine depends on various characteristics of headache with their associated constitutional symptoms such as nausea, vomiting, photophobia, and phonophobia. Relatively severe int...

Prolonged Migraine Stuttering Aura: Structural, Functional, and Video Neuroimaging Study of an Atypical Migraine Aura. A Case Report.

Mar 09, 2020

Stuttering is a disorder in the rhythm of speech characterized by an involuntary repetition, prolongation, and cessation of sounds. Neurogenic acquired stuttering is a very rare disorder which could r...

PAC1 receptor blockade reduces central nociceptive activity: new approach for primary headache?

Mar 09, 2020

Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) may play an important role in primary headaches. Preclinical evidence suggests that PACAP38 modulates trigeminal nociceptive activity ma...

Effect of Repetitive Transcranial Magnetic Stimulation on Pain Management: A Systematic Narrative Review.

Mar 09, 2020

Recently, clinicians have been using repetitive transcranial magnetic stimulation (rTMS) for treating various pain conditions. This systematic narrative review aimed to examine the use and efficacy of...

Validity of Algorithms for Identification of Individuals Suffering from Chronic Noncancer Pain in Administrative Databases: A Systematic Review.

Mar 09, 2020

Secondary analysis of health administrative databases is indispensable to enriching our understanding of health trajectories, health care utilization, and real-world risks and benefits of drugs among ...

Non-celiac gluten sensitivity and chronic refractory low back pain with spondyloarthritis features.

Mar 09, 2020

To propose the hypothesis that non-celiac gluten sensitivity is associated with chronic low-back pain related to spondyloarthritis, and a gluten free diet has a therapeutic benefit in a subgroup of pa...

Methamphetamine and Opioid Cue Database (MOCD): Development and Validation.

Mar 09, 2020

Drug cue reactivity (DCR) is widely used in experimental settings for both assessment and intervention. There is no validated database of pictorial cues available for methamphetamine and opioids.360 i...

The spatio-temporal distribution of naloxone administration events in rural Ohio 2010-16.

Mar 09, 2020

In 2017, Ohio had the second highest rate of drug overdose deaths in the United States. Current opioid related epidemiologic literature has begun to uncover the environmental level influences on the o...

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