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Orthopedics

Inhibition of copper chaperones sensitizes human and canine osteosarcoma cells to carboplatin chemotherapy.

Feb 17, 2020

Osteosarcoma (OSA) is the most common primary bone cancer in children, adolescents and dogs. Current combination surgical and chemotherapeutic treatments have increased survival. However, in recurrent...

Cyclins E1 and E2 in ER+ breast cancer: prospects as biomarkers and therapeutic targets.

Feb 17, 2020

Cyclin E1 is one the most promising biomarkers in estrogen receptor positive (ER+) breast cancer for response to the new standard of care drug class, CDK4/6 inhibitors. Because of its strong predictiv...

Is Bone Non-Union, Vertebral Deformity, or Spino-Pelvic Malalignment the Best Therapeutic Target for Amelioration of Low Back Pain after Osteoporotic Vertebral Fracture?

Feb 13, 2020

Cohort study (level 3).To identify independent risk factors for residual low back pain (LBP) following osteoporotic vertebral fracture (OVF).Non-union has been proposed as the primary cause of residua...

Traumatic Atlanto-occipital Dislocation: Analysis of 15 Survival Cases With Emphasis on Associated Upper Cervical Spine Injuries.

Feb 13, 2020

Retrospective case analyses.The aim of this study was to investigate the incidence and characteristics of associated upper cervical spine injuries in 15 survival cases of traumatic atlanto-occipital d...

Predictive Forward Dynamic Simulation of Manual Wheelchair Propulsion on a Rolling Dynamometer.

Feb 13, 2020

Research studies to understand the biomechanics of manual wheelchair propulsion often incorporate experimental data and mathematical models. This project aimed to advance this field of study by develo...

Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial.

Feb 13, 2020

Observational studies have suggested that accelerated surgery is associated with improved outcomes in patients with a hip fracture. The HIP ATTACK trial assessed whether accelerated surgery could redu...

Long-term use of dienogest for the treatment of primary and secondary dysmenorrhea.

Feb 13, 2020

To investigate the safety and efficacy of dienogest (DNG), a progestational 19-norsteroid, administered for 52 weeks in patients with primary and secondary dysmenorrhea.A total of 147 patients with ...

Certified Nurse Midwives as Teachers of Family Medicine Residents.

Feb 13, 2020

The high quality of obstetric care provided by certified nurse midwives (CNMs) has led some to hypothesize that collaboration with CNMs may encourage more family medicine (FM) residents to subsequentl...

Unmasking Identity: Observations From a Cohort of Entering Medical Students.

Feb 13, 2020

Professional identity formation (PIF) is increasingly recognized as a core element of medical education. The use of narrative reflection is traditionally the most common means to explore PIF. We explo...

Family Medicine Journal Club: To Tweet or Not to Tweet?

Feb 13, 2020

Online journal clubs have recently become popular, but their effectiveness in promoting meaningful discussion of the evidence is unknown. We aimed to understand the learner experience of a hybrid onli...

EHR Overtime: An Analysis of Time Spent After Hours by Family Physicians.

Feb 13, 2020

Time spent in the electronic health record (EHR), away from direct patient care, is associated with physician burnout. Yet there is a lack of evidence quantifying EHR use among family physicians. The ...

Alcohol and fast food sponsorship in sporting clubs with junior teams participating in the 'Good Sports' program: a cross-sectional study.

Feb 13, 2020

To examine: alcohol and fast food sponsorship of junior community sporting clubs; the association between sponsorship and club characteristics; and parent and club representative attitudes toward spon...

Intraoperative rupture of tuberculous pseudoaneurysm associated with spinal tuberculosis: A case report and literature review.

Feb 10, 2020

The increase in the incidence of tuberculosis in developing countries has resulted in increased reporting on more related complications. We report the successful management of an intraoperative sponta...

Outcomes after implementation of an open fracture clinical pathway.

Feb 10, 2020

Open fractures are associated with high rates of complication, morbidity and high economic costs. To improve outcomes, an open extremity fracture clinical pathway that protocolized surgical management...

Clinical, radiological, and patient-reported outcomes 13 years after pedicle screw fixation with balloon-assisted endplate reduction and cement injection.

Feb 10, 2020

In management of traumatic thoracolumbar burst fractures, short-segment pedicle screw fixation with balloon-assisted endplate reduction (BAER) and cement injection is a safe, feasible, and effective t...

Burden of fractures in France: incidence and severity by age, gender, and site in 2016.

Feb 10, 2020

Fractures are common events, but the exact incidence and severity of fractures have not been clearly determined for most anatomical sites. We estimated the incidence and severity of fractures in Franc...

Evaluation of the Efficacy of BI 425809 Pharmacotherapy in Patients with Schizophrenia Receiving Computerized Cognitive Training: Methodology for a Double-blind, Randomized, Parallel-group Trial.

Feb 10, 2020

BACKGROUND AND OBJECTIVE: Cognitive impairments associated with schizophrenia (CIAS) predict poor functional outcomes, but there are currently no approved pharmacological treatments for patients with...

Diaphragm and Lung Ultrasound Indices in Prediction of Outcome of Weaning from Mechanical Ventilation in Pediatric Intensive Care Unit.

Feb 10, 2020

To predict the added value of diaphragmatic and lung ultrasound indices (US) in anticipation of the outcome of mechanical ventilation of pediatric patients in the intensive care unit.This prospective ...

Mixed hemodiafiltration reduces erythropoiesis stimulating agents requirement in dialysis patients: a prospective randomized study.

Feb 10, 2020

Improved responsiveness to erythropoiesis stimulating agents (ESAs) in patients on on-line post-dilution hemodiafiltration (Post-HDF) compared with conventional hemodialysis (HD) was reported by some ...

Strategies to improve the implementation of healthy eating, physical activity and obesity prevention policies, practices or programmes within childcare services.

Feb 10, 2020

Despite the existence of effective interventions and best-practice guideline recommendations for childcare services to implement evidence-based policies, practices and programmes to promote child heal...

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