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Orthopedics General

Pain Education With Therapeutic Exercise in Chronic Nonspecific Low Back Pain Rehabilitation: A Critically Appraised Topic.

Feb 28, 2020

Clinical Scenario: Low back pain is widely prevalent in the general population as well as in athletes. Therapeutic exercise is a low-risk and effective treatment option for chronic pain that can be ut...

Consistency between anticholinergic burden scales in the elderly with fractures.

Feb 25, 2020

Falls and bone fractures are important causes of morbidity and mortality in the elderly. The objective of this study was to identify the degree of consistency between the anticholinergic scales used f...

Favorable skeletal benefit/risk of long-term denosumab therapy: A virtual-twin analysis of fractures prevented relative to skeletal safety events observed.

Feb 25, 2020

Antiresorptive therapies reduce fracture risk; however, long-term bone turnover inhibition may raise concerns about rare, but serious, skeletal adverse events-atypical femoral fracture (AFF) and osteo...

Radiofrequency echographic multi spectrometry for the prediction of incident fragility fractures: A 5-year follow-up study.

Feb 25, 2020

To investigate the effectiveness of the T-score values provided by Radiofrequency Echographic Multi Spectrometry (REMS) in the identification of patients at risk for incident osteoporotic fractures.A ...

Association between lower back pain and lower extremity pain among young volleyball players: A cross-sectional study.

Feb 25, 2020

Lower back pain (LBP), as well as lower extremity injuries, are major problems among young volleyball players. Nevertheless, only few studies have focused on the relationship between lower extremity i...

Investigation of the Effect of Secreted Factors from Mesenchymal Stem Cells on Disc Cells from Degenerated Discs.

Feb 25, 2020

Low back pain is experienced by a large number of people in western countries and may be caused and influenced by many different pathologies and psychosocial factors including disc degeneration. Disc ...

Accelerating bone defects healing in calvarial defect model using 3D cultured bone marrow-derived mesenchymal stem cells on demineralized bone particle scaffold.

Feb 18, 2020

Bone defects are usually difficult to be regenerated due to pathological states or the size of the injury. Researchers are focusing on tissue engineering approaches in order to drive the regenerative ...

Histone Hyperacetylation Mediates Enhanced IL-1β Production in LPS/IFN-γ stimulated Macrophages.

Feb 18, 2020

Under the condition of LPS/IFN-γ activation, macrophage metabolism is conversed from oxidative phosphorylation to glycolysis. In the present work, we analyzed whether glycolysis could affect IL-1β e...

Malignant struma ovarii with a robust response to radioactive iodine.

Feb 18, 2020

Struma ovarii is a rare, usually benign ovarian tumour with malignancy occurring in 3000 µg/L following recombinant TSH administration prior to her first dose of I131. At 25 months following radioiod...

Inhibition of PTP1B Phosphorylation Enhances Early Adhesion of Mesenchymal Stem Cells to Facilitate Fabrication of Tissue-Engineered Bone.

Feb 18, 2020

Enhancement of cell-matrix adhesion is preferable and crucial in various fields of tissue engineering. Integrins are important receptors that facilitate cell-matrix adhesion, mediated by intracellular...

Lumbar intervertebral disc characterization through quantitative MRI analysis: An automatic voxel-based relaxometry approach.

Feb 17, 2020

To develop an automated pipeline based on convolutional neural networks to segment lumbar intervertebral discs and characterize their biochemical composition using voxel-based relaxometry, and establi...

LncRNA KCNQ1OT1 accelerates fracture healing via modulating miR-701-3p/FGFR3 axis.

Feb 17, 2020

Emerging evidence highlights the role of the long noncoding RNA (lncRNA) KCNQ1OT1 in fracture healing. Osteoblast proliferation, migration, and survival are pivotal during this process. In this study,...

Pulsed Radiofrequency Treatment for Bertolotti's Syndrome Presenting with Low Back Pain: Report of Four Cases.

Feb 17, 2020

Pulsed radiofrequency (PRF) has been used successfully to treat myriad types of chronic pain, including spinal radicular pain and that associated with facet arthropathy. Although there are a few repor...

Oxytocin modulates intrinsic neural activity in patients with chronic low back pain.

Feb 17, 2020

Modulation of pain perception by oxytocin (OXT) has attracted increased scientific and clinical interest. Neural mechanisms underlying these effects are poorly understood. In this study, we aimed to i...

Use of portfolios in teaching communication skills and professionalism for Portuguese-speaking medical students.

Feb 17, 2020

This study aimed to analyse the effect of a portfolio with three activities fostering students' reflection, self-efficacy and teaching of communication skills and professionalism.A cross-sectional stu...

The Wickerhamiella/Starmerella clade - a treasure trove for the study of the evolution of yeast metabolism.

Feb 17, 2020

The Wickerhamiella and Starmerella genera form a clade (W/S clade) that branches close to Yarrowia lipolytica in the Saccharomycotina species tree. It comprises approximately 90 recognized species and...

Conservation and expansion of a necrosis-inducing small secreted protein family from host-variable phytopathogens of the Sclerotiniaceae.

Feb 17, 2020

Fungal effector proteins facilitate host-plant colonization and have generally been characterized as small secreted proteins (SSPs). We classified and functionally tested SSPs from the secretomes of t...

Bioinspired oxidation in the CYP of isomers orientin and isoorientin using Salen complexes.

Feb 17, 2020

Orientin and isoorientin are C-glycosidic flavonoids, considered as markers of some plant species as Passiflora edulis var. flavicarpa Degener and reported in the literature to have pharmacological pr...

Inhibition of copper chaperones sensitizes human and canine osteosarcoma cells to carboplatin chemotherapy.

Feb 17, 2020

Osteosarcoma (OSA) is the most common primary bone cancer in children, adolescents and dogs. Current combination surgical and chemotherapeutic treatments have increased survival. However, in recurrent...

Cyclins E1 and E2 in ER+ breast cancer: prospects as biomarkers and therapeutic targets.

Feb 17, 2020

Cyclin E1 is one the most promising biomarkers in estrogen receptor positive (ER+) breast cancer for response to the new standard of care drug class, CDK4/6 inhibitors. Because of its strong predictiv...

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