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Orthopedics General

Insulin receptor substrate-1 inhibits high-fat diet-induced obesity by browning of white adipose tissue through miR-503.

Jul 30, 2020

Genetic variation of insulin receptor substrate 1 (IRS-1) was found to modulate the insulin resistance of adipose tissues, but the underlying mechanism was not clear. To investigate how the IRS-1 was ...

Bone scan index can be a useful biomarker of survival outcomes in patients with metastatic castration-resistant prostate cancer treated with radium-223.

Jul 30, 2020

Bone metastasis of prostate cancer is associated with pain and reduced overall survival (OS). Radium-223, which is expected to reduce bone pain and prolong OS, was recently approved in Japan.The aim o...

Clinical and Psychosocial Factors Over Time Following an Acute Low Back Pain Episode.

Jul 27, 2020

Low back pain (LBP) is a prevalent condition with overwhelming healthcare costs and high disability rates. Characterization of clinical and psychosocial variables over time in patients experiencing an...

Supplementary Energy Increases Bone Formation during Arduous Military Training.

Jul 27, 2020

To investigate the effect of supplementary energy on bone formation and resorption during arduous military training in energy deficit.Thirty male soldiers completed an 8-week military combat course (m...

Trunk and Lower Extremity Movement Patterns, Stress Fracture Risk Factors, and Biomarkers of Bone Turnover in Military Trainees.

Jul 27, 2020

Military service members commonly sustain lower extremity stress fractures (SFx). How SFx risk factors influence bone metabolism is unknown. Understanding how SFx risk factors influence bone metabolis...

Dual source hybrid spectral micro-CT using an energy-integrating and a photon-counting detector.

Jul 27, 2020

Preclinical micro-CT provides a hotbed in which to develop new imaging technologies, including spectral CT using photon counting detector (PCD) technology. Spectral imaging using PCDs promises to expa...

Impact of Long-term, High-fat, and High-cholesterol Diet on Murine Vertebrae Bones.

Jul 27, 2020

As the percentage of overweight individuals in the population rises, diseases associated with excess weight resulting from poor nutrition are becoming more and more widespread. So far, the influence o...

Diamond-Blackfan Anemia.

Jul 27, 2020

Diamond-Blackan anemia (DBA) is the first ribosomopathy described and one of the constitutional inherited bone marrow failure syndromes. Erythroblastopenia is the major characteristic feature of the d...

The Effects of a Cognitive Dual Task on Jump-landing Movement Quality.

Jul 23, 2020

Investigations on movement quality deficits associated with jump landing are numerous, however, these studies are often performed in laboratories with little distraction to the participant. This is co...

Is the Lipid Content of the Psoas Major Correlated with Chronic Low Back Pain and Spinopelvic Alignment? A Magnetic Resonance Spectroscopic Study.

Jul 23, 2020

Cross-sectional observational study.This study aimed to analyze any potential associations of extramyocellular lipid (EMCL) and intramyocellular lipid (IMCL) contents with (1) the intensity of low bac...

Effect of calcium phosphate and silk fibroin nanofibers tuning on properties of calcium sulfate bone cements.

Jul 23, 2020

Calcium sulfate (CS) bone cements have been used as bone substitutes for a long history, but it is limited to apply in clinical trials due to its rapid degradation rate and brittleness. This work aims...

Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome.

Jul 23, 2020

Gray platelet syndrome (GPS) is a rare recessive disorder caused by biallelic variants in NBEAL2 and characterized by bleeding symptoms, the absence of platelet ɑ-granules, splenomegaly and bone marr...

FeO/Bioactive glass nanostructure: A promising therapeutic platform for osteosarcoma treatment.

Jul 23, 2020

An effective strategy of hyperthermia-chemotherapy-regeneration for bone-related cancer treatments is presented. For this purpose, a new approach of magnetic particles (MPs) encapsulated in bioactive ...

Preprosthesis fracture of femoral and loosening of the femoral prosthesis during closed reduction of hip dislocation: A case report.

Jul 23, 2020

Dislocation after bipolar hip hemiarthroplasty is an uncommon complication. Although closed manoeuvre reduction under general anaesthesia is a common and effective method for dislocation of the hemiar...

Fragility fractures and health-related quality of life: does socio-economic status widen the gap? A population-based study.

Jul 20, 2020

Studying 12,839 fracture cases and 91,426 controls, we found that fractures of the spine and hip are associated with clinically important HRQoL deficits up to 5 years post-fracture. Fracture cases wi...

Bigger Necks Are Not Enough: An Examination of Neck Circumference in Incoming College Athletes.

Jul 20, 2020

Neck circumference is quick and simple to measure and thus an attractive proxy of neck strength, a putative mechanism underlying risk of sport-related concussion (SRC). Research, however, is limited o...

Efficacy of conservative therapy in older people with nonspecific low back pain: A systematic review with meta-analysis and GRADE recommendations.

Jul 20, 2020

This systematic review aimed to investigate the effectiveness of conservative therapy in older people with nonspecific low back pain.Searches were conducted on Medline, Amed, Embase, Cochrane, Psycinf...

Prognostic value of different metastatic sites for patients with FIGO stage IVB endometrial cancer after surgery: A SEER database analysis.

Jul 20, 2020

This study aimed to investigate the association between different metastatic sites and survival in endometrial cancer (EC) patients with International Federation of Gynecology and Obstetrics (FIGO) st...

Technical note: Efficient and accurate MRI-only based treatment planning of the prostate using bulk density assignment through atlas-based segmentation.

Jul 20, 2020

This study investigates the dosimetric accuracy as well as the robustness of a bulk density assignment approach to MRI-only based treatment planning of the prostate, with bulk density regions automati...

UPLC-MS metabolomics method provides valuable insights into the effect and underlying mechanisms of Rhizoma Drynariae protecting osteoporosis.

Jul 20, 2020

Osteoporosis (OP) is a metabolic bone disease in which that volume of bone tissue per unit volume decrease, which is a common disease disturbing the elderly or postmenopausal women. Rhizoma Drynariae ...

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