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Orthopedics General

Enhanced Osteolysis Targeted Therapy through Fusion of Exosomes Derived from M2 Macrophages and Bone Marrow Mesenchymal Stem Cells: Modulating Macrophage Polarization.

Oct 09, 2023

Aseptic loosening of prostheses is a highly researched topic, and wear particle-induced macrophage polarization is a significant cause of peri-prosthetic osteolysis. Exosomes derived from bone marrow ...

Quantifying Success After First Revision Reverse Total Shoulder Arthroplasty: The Minimal and Substantial Clinically Important Percentage Of Maximal Possible Improvement.

Oct 02, 2023

When patients require reoperation after primary shoulder arthroplasty, revision reverse total shoulder arthroplasty (rTSA) is most commonly performed. However, defining clinically important improvemen...

Elbow hemiarthroplasty and total elbow arthroplasty provided a similar functional outcome for unreconstructable distal humeral fractures in patients aged 60 years or older: a multicenter randomized controlled trial.

Oct 02, 2023

Semiconstrained total elbow arthroplasty (TEA) is an established treatment for elderly patients with distal humeral fractures not amenable to stable internal fixation (unreconstructable). In recent ye...

"Waiting for the best day of your life". A qualitative interview study of patients' and clinicians' experiences of Perthes' disease.

Oct 02, 2023

Perthes' disease is an idiopathic avascular necrosis of the developing femoral head, often causing deformity that impairs physical function. Current treatments aim to optimize the joint reaction force...

Changing Patterns of Zygomaticomaxillary Complex Fractures: A Retrospective Study.

Sep 25, 2023

Limited research exists regarding the incidence and variations of zygomaticomaxillary complex (ZMC) fracture patterns and their correlation with the mechanism of injury. Hence, further research is ind...

Relationships between frailty and exercise capacity in patients undergoing hemodialysis: A cross-sectional study.

Sep 25, 2023

Hemodialysis (HD) patients have a high prevalence of frailty. The association between frailty and exercise capacity in HD patients has not been established. This study aimed to clarify the relationshi...

Sclerotic-type chronic graft-versus-host disease exhibits activation of Th1 and OX40 cytokines.

Sep 25, 2023

Sclerotic-type cutaneous chronic graft-versus-host disease (ScGvHD) is a severe complication of allogeneic hematopoietic stem cell transplantation, with profound morbidity. A dearth of effective, targ...

Klotho overexpression is frequently associated with upstream rearrangements in fusion-negative phosphaturic mesenchymal tumors of bone and sinonasal tract.

Sep 25, 2023

Phosphaturic mesenchymal tumors (PMT) are uncommon neoplasms that cause hypophosphatemia/osteomalacia mainly by secreting fibroblast growth factor 23. We previously identified FN1::FGFR1/FGF1 fusions ...

Colleters in leaves of Mespilus germanica L. (Rosaceae): Micromorphology, histochemistry and fluorescence.

Sep 11, 2023

New data on the micromorphology, histochemistry, and fluorescence of colleters on leaf structures at different stages of development (leaf blade, stipules, and petiole) of Mespilus germanica L. are pr...

Increases in Sleep Difficulties and Psychological Symptoms are Associated with the Increase of Chronic Back Pain in Adolescents: The HBSC Study 2002-2018.

Sep 11, 2023

Cross-national research using data from the Health Behavior in School-aged Children (HBSC) survey showed an increase in the prevalence of chronic back pain from 2002 to 2014. However, it is unknown if...

Relationship between hippocampal gene expression and cognitive performance differences in visual discrimination learning task of male rats.

Sep 11, 2023

Learning to discriminate between environmental visual stimuli is essential to make right decisions and guide appropriate behaviors. Moreover, impairments in visual discrimination learning are observed...

Metformin reverses impaired osteogenesis due to hyperglycemia-induced neutrophil extracellular traps formation.

Sep 04, 2023

Diabetic patients suffer from delayed fracture healing and impaired osteogenic function, but the underlying pathophysiological mechanisms are not fully understood. Neutrophil extracellular traps (NETs...

Indices for the brittleness of pharmaceutical tablets: a reassessment.

Sep 04, 2023

Brittleness is an important mechanical property. In the classical sense, a material is considered brittle if, during loading, it behaves elastically until failure. Nevertheless, it is also sometimes u...

Functional Hypothalamic Amenorrhea: Recognition and Management of a Challenging Diagnosis.

Sep 04, 2023

Functional hypothalamic amenorrhea is responsible for approximately a third of the cases of secondary amenorrhea. The condition is a result of disturbances in gonadotropin-releasing hormone pulsatile ...

Influence of stem design parameters on periprosthetic femoral fractures examined by subject specific finite element analyses.

Aug 28, 2023

Due to the increasing number of periprosthetic femoral fractures (PFF), the optimisation of implant design gains importance. For the presented research a validated, subject specific finite element mod...

The role of the depth of resection of the distal tibia on biomechanical performance of the tibial component for TAR: A finite element analysis with three implant designs.

Aug 28, 2023

The depth of resection of the tibia bone in total ankle replacement (TAR) may influence implant-bone micromotion and stress shielding. High implant-bone micromotion and stress-shielding lead to asepti...

Analysis and multiple index evaluation of SPO distribution of bone traction needles for pelvic fracture reduction.

Aug 28, 2023

For robot-assisted pelvic fracture reduction, at least two bone needles need to be inserted into the ilium of the affected pelvis, and the robot clamping device is connected with the bone needles. The...

Hip fracture surgery performed by cadaveric simulation-trained versus standard-trained orthopaedic trainees: a preliminary multicentre randomized controlled trial.

Aug 21, 2023

To evaluate if, for orthopaedic trainees, additional cadaveric simulation training or standard training alone yields superior radiological and clinical outcomes in patients undergoing dynamic hip scre...

Assessing the risk of re-fracture related to the percentage of partial union in scaphoid waist fractures.

Aug 21, 2023

There is ambiguity surrounding the degree of scaphoid union required to safely allow mobilization following scaphoid waist fracture. Premature mobilization could lead to refracture, but late mobilizat...

"Geriatric Proximal Humerus Fracture Operative Management: A TRUVEN Health Analytics Database Study (2015-2020)".

Aug 14, 2023

The purpose of this study is to assess the trends in operative management of geriatric (≥65 years) proximal humerus fractures during a six-year period (2015-2020) within an insurance claims database...

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