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Orthopedics General

A Comparison of Clinical Spinal Mobility Measures to Experimentally Derived Lumbar Spine Passive Stiffness.

Oct 15, 2020

Spinal stiffness and mobility assessments vary between clinical and research settings, potentially hindering the understanding and treatment of low back pain. A total of 71 healthy participants were e...

Classification of various sources of error in range assessment using proton radiography and neural networks in head and neck cancer patients.

Oct 15, 2020

This study evaluates the suitability of convolutional neural networks (CNN) to automatically process proton radiography (PR) based images. CNNs are used to classify PR images impaired by several sourc...

Click chemistry based biopolymeric hydrogels for regenerative medicine.

Oct 15, 2020

Click chemistry is not a single specific reaction, but describes ways of generating products following examples in nature. Click reactions occur in one pot, are not disturbed by water, generate minima...

Crosstalk between CML cells with HUVECS and BMSCs through CML derived exosomes.

Oct 15, 2020

Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm characterized by presence of the BCR-ABL fusion gene which encodes the constitutively active BCR-ABL chimeric protein. Imatinib is first...

Functional outcome of gastrocnemius advancement flap augmented with short flexor hallucis longus tendon transfer in chronic Achilles tear.

Oct 12, 2020

There are various techniques of Achilles tendon (TA) repair and reconstruction in chronic Achilles tear. However, there is no clear consensus on the relevance of one method over the other. The short f...

Lisfranc injury: A review and simplified treatment algorithm.

Oct 12, 2020

Lisfranc injuries encompass large spectrum of injuries varying from low energy to high energy complex fracture dislocations. Whilst multiple complex classification systems exist; these do little to ai...

The influence of age, gender and the FKBP5 genotype on subjective health complaints in the Norwegian working population.

Oct 12, 2020

In the present study we examined the potential association between age, gender, the genetic variant FKBP5 rs9470080 and subjective health complaints.The data were collected through a three-wave nation...

Serum osteocalcin is associated with subjective stress in people with depression and type 2 diabetes.

Oct 12, 2020

Low serum osteocalcin is a risk factor for type 2 diabetes mellitus (T2DM), and osteocalcin release from bone is associated with an acute stress response in mice. Both diabetes and stress are associat...

Silencing KIF18B enhances radiosensitivity: identification of a promising therapeutic target in sarcoma.

Oct 12, 2020

Sarcomas are rare heterogeneous tumours, derived from primitive mesenchymal stem cells, with more than 100 distinct subtypes. Radioresistance remains a major clinical challenge for sarcomas, demanding...

Relationship between bone turnover markers and oxidative stress in children with type 1 diabetes mellitus.

Oct 12, 2020

Oxidative stress in children with type 1 DM (T1DM) may negatively affect the bone.This study included 40 children with T1DM as the patient group and 40 healthy children as the control group. Plasma al...

Bifidobacterium adolescentis supplementation attenuates fracture-induced systemic sequelae.

Oct 08, 2020

The gut microbiota is an important contributor to both health and disease. While previous studies have reported on the beneficial influences of the gut microbiota and probiotic supplementation on bone...

Hematological and Chemical Profiles in a Porcine Model of Severe Multiple Trauma.

Oct 08, 2020

Clinical chemistry and hematological tests are widely used to monitor the clinical course of several diseases. However, these parameters are sparse in large-animal models of multiple trauma (MT). Thus...

The use of omega-3 fatty acids in the treatment of oral diseases.

Oct 08, 2020

Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) have been reported to exert important roles in the inflammatory response. There are many inflammatory diseases in dentistry which support the administr...

Irradiation-free RIC HSCT has a tolerable safety profile and is effective therapy for pediatric bone marrow failure syndromes.

Oct 08, 2020

For patients with bone marrow failure syndromes (BMFS) who may tolerate gradual donor engraftment and achieve adequate disease control with stable mixed chimerism, RIC regimens may be preferable to my...

Optimal duration of prior endocrine therapy predicts the efficacy of Fulvestrant in a real-world study for patients with hormone receptor-positive and HER2-negative advanced breast cancer.

Oct 08, 2020

Fulvestrant 500 mg is standard of care for endocrine therapy-naive or pretreated women with hormone receptor-positive (HR+) metastatic breast cancer (MBC). This study was conducted to explore the pot...

Contemporary Population-Based Analysis of Bone Mineral Density Testing in Men Initiating Androgen Deprivation Therapy for Prostate Cancer.

Oct 08, 2020

Androgen deprivation therapy (ADT) is a cornerstone of treatment for advanced prostate cancer (PCa); however, it accelerates the loss of bone mineral density (BMD), which increases fracture risk. Guid...

Incidence of anterior cruciate ligament graft tears in high-risk populations: An analysis of professional athlete and pediatric populations.

Oct 05, 2020

Professional athletes are at increased risk of injury with high activity levels and additional pressure to return to sports quickly after anterior cruciate ligament (ACL) injury. The purpose of this s...

Fatigue fracture of the femoral component in total knee replacement.

Oct 05, 2020

Fracture of femoral component in total knee arthroplasty (TKA) has become a rare complication with improvements in metal alloy manufacturing technology.We report two cases of fracture of femoral compo...

An update on graft-tunnel mismatch in anterior cruciate ligament reconstruction: A survey of the experts in the field of orthopedic sports medicine demonstrates no clear consensus in management.

Oct 05, 2020

The purpose of this study was to identify and report on the rate at which leaders in orthopaedic surgery are encountering GTM, their treatment methods and to identify whether these clinicians' demogra...

Factors affecting the disparity between preoperative planning and postoperative correction status in distal femoral osteotomy.

Oct 05, 2020

The purposes of this study were to evaluate whether the planning method using the contralateral limb status is reasonable and to determine the disparity between the preoperative planning and actual po...

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