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Orthopedics General

CGRP-modulated M2 macrophages regulate osteogenesis of MC3T3-E1 via Yap1.

Nov 26, 2020

Bone fractures are one of the most frequent injuries in the musculoskeletal system. Despite the best treatment efforts, a large proportion of bone fracture cases still display undesirable outcomes. He...

Can we predict the evolution of untreated first stage posterior vaginal wall prolapse in women operated for anterior or apical prolapse?

Nov 26, 2020

The aim of this study was to evaluate the correlation between pre-existing conditions and worsening of Stage I untreated posterior vaginal wall prolapse (PVWP) after vaginal hysterectomy and anterior ...

Outcomes Following Revision of the Revision Total Elbow Arthroplasty.

Nov 23, 2020

There is very little in the literature on the outcomes of Revision of Revision Total Elbow Arthroplasty (RRTEA). Our aim was to report the outcomes of this rarely performed procedure.Retrospective ide...

Annual Trends and Geographic Variation in the Utilization of Imaging in Pediatric Patients with Low Back Pain in the United States.

Nov 23, 2020

Low back pain (LBP) is increasingly burdening the pediatric population. Advanced imaging such as computerized tomography (CT) scans and magnetic resonance imaging (MRIs) associated with LBP impose sig...

Post-translational modifications in collagen type I of bone in a mouse model of aging.

Nov 23, 2020

The fracture resistance of cortical bone and matrix hydration are known to decline with advanced aging. However, the underlying mechanisms remain poorly understood, and so we investigated levels of ma...

Effects of valproate, lamotrigine, and levetiracetam monotherapy on bone health in newly diagnosed adult patients with epilepsy.

Nov 23, 2020

The aim of this study was to evaluate the effects of valproate (VPA), lamotrigine (LTG), and levetiracetam (LEV) on bone turnover and bone mineral density (BMD) in newly diagnosed adult patients with ...

The role of the M1/M2 microglia in the process from cancer pain to morphine tolerance.

Nov 23, 2020

Cancer pain, especially bone cancer pain, is a pain state often caused by inflammation or dysfunctional nerves. Moreover, in the management of cancer pain, opioid especially morphine is widely used, h...

The role of microRNAs in bone development.

Nov 23, 2020

Epigenetic regulation is critical for proper bone development. Evidence from a large body of published literature informs us that microRNAs (miRNAs) are important epigenetic factors that control many ...

The Success Rate of Ultrasound Guided Sacroiliac Joint Steroid Injections in Sacroiliitis. Are We Getting Better?

Nov 19, 2020

Sacroiliac joint is one of the most common sources of low back pain, however it is difficult to place the needle accurately inside the joint space without image guidance, improvement of ultrasound tec...

Cost-effectiveness of interventions for musculoskeletal foot and ankle conditions: a systematic review.

Nov 19, 2020

Musculoskeletal conditions of the foot and ankle are common, yet the cost-effectiveness of the variety of treatments available is not well defined. The aim of this systematic review was therefore to i...

Effect of Induced Incomplete Ossification of the Humeral Condyle on Ex Vivo Humeral Condylar Biomechanics.

Nov 19, 2020

 The aim of this study was to investigate the effects of an induced incomplete ossification of the humeral condyle (IOHC) lesion on canine humeral condylar biomechanics. Nine paired cadaveric elb...

The utility of ADC value in diffusion-weighted whole-body MRI in the follow-up of patients with multiple myeloma. Correlation study with F-FDG PET-CT.

Nov 19, 2020

To analyze the feasibility of DWI-MRI and ADC to evaluate treatment response in patients with multiple myeloma (MM). To correlate the variations of ADC and SUVmax in F-FDG PET-CT.27 patients with MM t...

Degradable calcium deficient hydroxyapatite/PLGA bilayer scaffold through integral molding 3D printing for bone defect repair.

Nov 19, 2020

A novel method was developed for calcium deficient hydroxyapatite (CDHA) scaffold 3D printing, through which a bilayer scaffold was fabricated by integral molding of individual CDHA and PLGA. The hydr...

Safety of percutaneous versus transjugular liver biopsy: A propensity score matched analysis.

Nov 19, 2020

This study sought to identify the complication, mortality, and readmission rates of patients undergoing either percutaneous (PCLB) or transjugular liver biopsy (TJLB) when propensity matched for demog...

Helmets Protect Pediatric Bicyclists From Head Injury and Do Not Increase Risk of Cervical Spine Injury.

Nov 16, 2020

Only 21 states have mandatory helmet laws for pediatric bicyclists. This study sought to determine the incidence of helmeted riders among pediatric bicyclists involved in a collision and hypothesized ...

Rapid Administration of Ketamine for Abscess Drainage in Children-A Dose Finding Study.

Nov 16, 2020

To estimate the minimum dose and total sedation time of rapidly infused ketamine that achieves 3 to 5 minutes of effective sedation in children undergoing abscess incision and drainage in the emergenc...

Pulpectomy versus Extraction for the Treatment of Nonvital Primary Second Molars: A Retrospective Chart Review.

Nov 16, 2020

The current investigation evaluated parameters leading to the utilization of pulpectomy versus extraction for treatment of nonvital primary second molars.This retrospective chart review identified pat...

A Retrospective CBCT Study of the Relationship between Mandibular Symphysis Bone Density and Mandibular Growth Direction.

Nov 16, 2020

The objective of this retrospective study was to investigate the relationship between mandibular symphysis bone density (BD) and mandibular growth direction in adolescent patients by facilitating the ...

Effect of Single Versus Multiple Fractures on Systemic Bone Loss in Mice.

Nov 16, 2020

Systemic bone loss after initial fracture contributes to an increased risk of secondary fracture. Clinical research has revealed an association between the risk of future fracture and the number or ma...

The severity of hepatic disorder is related to vertebral microstructure deterioration in cadaveric donors with liver cirrhosis.

Nov 12, 2020

Patients with liver cirrhosis (LC) commonly suffer from osteoporosis and vertebral fracture, but data about their vertebral micro-architectural changes are still limited. This study aimed to evaluate ...

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