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Ophthalmology General

Catenin alpha 1 mutations cause familial exudative vitreoretinopathy by overactivating Norrin/beta-catenin signaling.

Jan 28, 2021

Familial exudative vitreoretinopathy (FEVR) is a severe retinal vascular disease that causes blindness. FEVR has been linked to mutations in several genes associated with inactivation of the Norrin/β...

Evaluation of the Difference between Predicted and Measured Central Corneal Thickness Reduction after SMILE and Femtosecond Laser-assisted LASIK for Myopia.

Jan 28, 2021

: To evaluate the agreement between the predicted and measured central corneal thickness (CCT) reduction after the small incision lenticule extraction (SMILE) surgery and femtosecond laser-assisted in...

[Prevalence of visual impairment in school-age children: Data analysis from PlanVue® pilot project].

Jan 28, 2021

To assess the prevalence of visual disturbances among school-aged children in prioritized education zones in France.The PlanVue® pilot project was designed to detect and manage visual disturbances in...

Myopia progression from wearing first glasses to adult age: the DREAM Study.

Jan 28, 2021

Data on myopia progression during its entire course are scarce. The aim of this study is to investigate myopia progression in Europeans as a function of age and degree of myopia from first prescriptio...

Diagnostic Performance of a Novel Noninvasive Workup in the Setting of Dry Eye Disease.

Jan 28, 2021

To evaluate the diagnostic performance of a novel noninvasive automated workup employed for the diagnosis of dry eye disease (DED).One hundred patients with mild to moderate DED and 100 matched contro...

The Relationship of Dry Eye Disease With Depression in Saudi Arabia: A Cross-Sectional Study.

Jan 28, 2021

Objective Estimate the prevalence of depression among individuals with a dry eye disease (DED) in Saudi Arabia using two questionnaires: Patient Health Questionnaire (PHQ-9) and Dry Eye Questionnaire ...

Role of CD4+ T Helper Cells in the Development of BAC-Induced Dry Eye Syndrome in Mice.

Jan 28, 2021

To evaluate the role of CD4+ T helper cells in benzalkonium chloride (BAC)-induced ocular surface disorder in C57BL/6 mice.Topical 0.075% BAC was applied twice daily in C57BL/6 mice for 7 consecutive ...

Age Factor in Determining Outcomes of SMILE Surgeries

Jan 18, 2021

Small incision lenticule extraction or SMILE is a simple laser eye surgery. It is a minimally invasive procedure for treating refractive errors like astigmatism, hyperopia, presbyopia, and myopia. It ...

Diagnosis and Evaluation of Neovascularization using OCTA versus Dye Angiography

Jan 18, 2021

Patients with punctate inner choroidopathy (PIC) require proper eye care. They develop secondary complications like choroidal neovascularization (CNV). Clinicians have to monitor these disorders and p...

Central Sparing and Geographic atrophy in Age-related Eye Diseases

Jan 18, 2021

Aging patients have macular degeneration that leads to poor vision. The sharpness of their eyesight depends on the central macular region. A 1 mm diameter zone is crucial for ascertaining the patient'...

The Role of Contact Lenses And Cornea Culture In Managing Bacterial Keratitis

Jan 18, 2021

Bacterial keratitis is the infection of the cornea that leads to pain, redness, and blurred vision. Those who wear contact lenses are susceptible to this disease. Low maintenance and cleaning of the l...

Glaucoma screening for high-risk African-Caribbean in London

Jan 18, 2021

Glaucoma damages the optic nerve and leads to total blindness. Multiple genetic factors affect the adult-onset of this disease. Early-onset is characterized by autosomal dominant or recessive inherita...

Quantitative assessment of visual pathway function in blind retinitis pigmentosa patients.

Jan 18, 2021

The current methods used to assess visual function in blind retinitis pigmentosa (RP) patients are mostly subjective. We aimed to identify effective, objective methods.We enrolled patients diagnosed w...

Predicting long-term neurodevelopmental outcomes in very preterm neonates by umbilical cord gas parameters.

Jan 18, 2021

The predictive value of acidemia at birth on long-term neurodevelopmental outcomes remains poorly understood, especially in preterm neonates.This study aimed to assess the relationship between the umb...

Impact of measured total keratometry versus anterior keratometry on the refractive outcomes of the AT TORBI 709-MP toric intraocular lens.

Jan 18, 2021

The aim of this study was to compare the visual and refractive outcomes of total keratometry (TK) versus anterior keratometry (AK) measurements of the IOLMaster 700® (Carl Zeiss Meditec AG, Jena, Ger...

A Randomized, Placebo-Controlled Phase II Clinical Trial of 0.01% or 0.02% Cyclosporin A with 3% Trehalose in Patients with Dry Eye Disease.

Jan 18, 2021

To compare the efficacy and safety of HU00701 (0.01% cyclosporin  + 3% trehalose), HU007 (0.02% cyclosporin  + 3% trehalose) (all w/v), and placebo in patients with moderate to severe dry eye...

A Randomized Double-Masked Phase 2a Trial to Evaluate Activity and Safety of Topical Ocular Reproxalap, a Novel RASP Inhibitor, in Dry Eye Disease.

Jan 18, 2021

To determine whether reproxalap, a novel reactive aldehyde species (RASP) inhibitor, is safe and effective for the treatment of the signs and symptoms of dry eye disease (DED). In a randomized doubl...

Pigment epithelium-derived factor enhances the suppressive phenotype of regulatory T-cells in a murine model of dry eye disease.

Jan 18, 2021

Pigment Epithelium-derived Factor (PEDF) is a widely expressed 50kD glycoprotein belonging to the serine protease inhibitor family with well-established anti-inflammatory functions. Recently, we demon...

Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated within 6 Months of Disease Onset.

Jan 18, 2021

To evaluate the efficacy of a single intravitreal injection of rAAV2/2-ND4 in subjects with visual loss from Leber hereditary optic neuropathy (LHON).RESCUE is a multicenter, randomized, double-masked...

Retinal nonperfusion in optical coherence tomography angiography.

Jan 18, 2021

Retinal nonperfusion (NP) is a biomarker for assessment of the severity of diabetic retinopathy and retinal vein occlusion. However, various conditions mimic the retinal NP flow void signals that are ...