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Ophthalmology General

Effect of Intravitreous Anti-Vascular Endothelial Growth Factor vs Sham Treatment for Prevention of Vision-Threatening Complications of Diabetic Retinopathy: The Protocol W Randomized Clinical Trial.

Apr 01, 2021

The role of anti-vascular endothelial growth factor injections for the management of nonproliferative diabetic retinopathy (NPDR) without center-involved diabetic macular edema (CI-DME) has not been c...

Efficacy of intravitreal ziv-aflibercept in patients with macular edema following retinal vein occlusion in Korle-Bu Teaching Hospital, Ghana: a retrospective case series.

Apr 01, 2021

To evaluate the efficacy of ziv-aflibercept in Ghanaian patients with macular edema (ME) secondary to retinal vein occlusion (RVO).In this retrospective study, the medical records of patients with ME ...

Effect of trabeculectomy on optic nerve head and macular vessel density: an optical coherence tomography angiography study.

Apr 01, 2021

To investigate the effect of trabeculectomy on peripapillary and macular vessel density (VD) using optical coherence tomography angiography (OCT-A) in patients with primary open-angle glaucoma.This is...

Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis.

Apr 01, 2021

Glucocorticoids are widely used as an ophthalmic medication. A common, sight-threatening adverse event of glucocorticoid usage is ocular hypertension, caused by dysfunction of the conventional outflow...

Axenfeld-Rieger syndrome combined with a foveal anomaly in a three-generation family: a case report.

Apr 01, 2021

Axenfeld-Rieger syndrome (ARS) is a rare autosomal dominant eye disorder that can also affect other organs of the human body. The condition is primarily characterized by the anterior segmental abnorma...

Controlled release of triamcinolone from an episcleral micro film delivery system for open-globe eye injuries and proliferative vitreoretinopathy.

Mar 29, 2021

Open globe trauma is the major cause for single eye blindness that stem from subsequent proliferative vitreoretinopathy (PVR). Though biomaterials and tissue engineering have significantly advanced dr...

Overexpression of STARD3 attenuates oxidized LDL-induced oxidative stress and inflammation in retinal pigment epithelial cells.

Mar 29, 2021

Age-related macular degeneration (AMD) is the most common cause of visual disorder in aged people and may lead to complete blindness with ageing. The major clinical feature of AMD is the presence of c...

Prediction of distance visual acuity in presbyopic astigmatic subjects.

Mar 29, 2021

This study was aimed to determine the effect of the amount of astigmatism on distance visual acuity, and to provide a prediction formula of visual acuity according to astigmatism, in a presbyopic popu...

Outcomes and complications of implantable collamer lens for mild to advance keratoconus.

Mar 29, 2021

To evaluate the outcome and safety of implantable collamer lens (ICL; (Visian, STAAR Surgical, Monrovia, CA, USA) in mild to advance keratoconus patients with myopia and myopic astigmatism.This retros...

Associations between visual function and magnitude of refractive error for emmetropic to moderately hyperopic 4- and 5-year-old children in the Vision in Preschoolers - Hyperopia in Preschoolers Study.

Mar 29, 2021

To evaluate associations between visual function and the level of uncorrected hyperopia in 4- and 5-year-old children without strabismus or amblyopia.Children with spherical equivalent (SE) cycloplegi...

Rabbit models of dry eye disease: Current understanding and future needs for translational approaches.

Mar 29, 2021

The dry eye disease (DED) is rising as an eye health pandemic, affecting millions across the world. The development of novel drugs, drug delivery systems, and targeted therapies for addressing the inf...

Human precorneal tear film and lipid layer dynamics in meibomian gland dysfunction.

Mar 29, 2021

To evaluate the precorneal tear film (PCTF) and lipid layer (TFLL) thicknesses and thinning rates in meibomian gland dysfunction (MGD) using a combined ultra-high-resolution optical coherence tomograp...

Diquafosol tetrasodium elicits total cholesterol release from rabbit meibomian gland cells via P2Y purinergic receptor signalling.

Mar 29, 2021

Diquafosol tetrasodium (DQS), a purinergic P2Y receptor agonist, stimulates secretion of both water and mucins from the conjunctiva into tears. Hence, DQS-containing eye drops have been approved as a ...

Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction.

Mar 29, 2021

Homo sapiens evolved under conditions of intermittent food availability and prolonged fasting between meals. Periods of fasting are important for recovery from meal-induced oxidative and metabolic str...

Evaluation of morphological characteristics of diabetic macular edema in patients with non-proliferative versus proliferative diabetic retinopathy: a spectral-domain optical coherence tomography study.

Mar 29, 2021

To evaluate the morphological characteristics in patients with diabetic macular edema (DME), either with co-existent non-proliferative diabetic retinopathy (NPDR) or with PDR.Retrospective study inclu...

Retrospective study of aflibercept in combination therapy for high-risk proliferative diabetic retinopathy and diabetic maculopathy.

Mar 29, 2021

To evaluate whether anti-vascular endothelial growth factor (VEGF) therapy combined with panretinal photocoagulation could reverse diabetic retinopathy (DR).Fifty-two patients (72 eyes) with high-risk...

The Role of PGS/PCL Scaffolds in Promoting Differentiation of Human Embryonic Stem Cells into Retinal Ganglion Cells.

Mar 29, 2021

The stem cell-based retinal ganglion cells (RGCs) replacement therapy offers a potential to restore vision in progressive optic neuropathies including glaucoma by replacing degenerated RGCs and by sim...

Factors Associated with the Macular Ganglion Cell-Inner Plexiform Layer Thickness in a Cohort of Middle-aged U.S. Adults.

Mar 29, 2021

The macular ganglion cell-inner plexiform layer (mGCIPL) may serve as a quick and easily obtained measure of generalized neurodegeneration. Investigating factors associated with this thickness could h...

Derivation of Induced Pluripotent Stem Cell (iPSC) Lines from Patient-Specific Peripheral Blood Mononuclear Cells (PBMC) Using Episomal Vectors.

Mar 29, 2021

Inherited retinal diseases (IRDs) are a diverse group of rare eye disorders, resulting in vision loss or blindness. The underlying reason is mutation in one or more than 250 different genes associated...

Corneal and lens densitometry in patients with vernal keratoconjunctivitis.

Mar 25, 2021

To evaluate corneal and crystalline lens densitometry in patients with vernal keratoconjunctivitis (VKC).This is a case-control study. Patients with VKC and age-gender-matched healthy controls underwe...