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Ophthalmology General

Genetic testing results of children suspected to have Stickler syndrome type collagenopathy after ocular examination.

May 06, 2021

Stickler syndrome is a collagenopathy that is typically COL2A1-related (autosomal dominant) and less commonly related to other collagen gene mutations. Diagnosis is straightforward when a child has my...

Patient-reported experience of dry eye management: An international multicentre survey.

May 06, 2021

To explore the journey taken by patients in a range of different countries to manage their dry eye symptoms.Members of the general public who responded positively to the question "Do your eyes ever fe...

Pathophysiology of Meibomian Glands - An Overview.

May 06, 2021

: The meibomian glands are located in the tarsal plate of the upper and lower eyelid and are responsible for the production of a lipid-rich secretion, the meibum, which forms the outer component of th...

Established soft contact lens wearers' awareness of and initial experiences with orthokeratology.

May 06, 2021

To understand the initial awareness of and experience with orthokeratology in a group of adult, symptomatic, soft contact lens (CL) wearers.This was a prospective, 3-month, open-label study of symptom...

Bilirubin is inversely related to diabetic peripheral neuropathy assessed by sural nerve conduction study.

May 06, 2021

Diagnosis of diabetic peripheral neuropathy (DPN) depends on subjective findings, disturbing certain investigations for DPN risks. Bilirubin protects against vascular complications by reducing oxidati...

Erectile Dysfunction in Type-2 Diabetes Mellitus Patients: Predictors of Early Detection and Treatment.

May 06, 2021

To identify risk factors and potential predictors of erectile dysfunction (ED) in type-2 diabetes mellitus (T2DM) patients for early detection and treatment.A retrospective cohort was used to assess t...

Laser in Glaucoma and Ocular Hypertension Trial (LIGHT) in China A Randomized Controlled Trial: Design and Baseline Characteristics.

May 06, 2021

To describe the baseline characteristics of a trial to evaluate whether selective laser trabeculoplasty (SLT), as a first-line treatment, provides superior economic and health-related quality of life ...

Activation of Insulin-Like Growth Factor-2 Ameliorates Retinal Cell Damage and Exerts Protection in in vitro Model of Diabetic Retinopathy.

May 06, 2021

The major event in the development of diabetes-related blindness and vision impairment is the onset of retinal cell damage. Overall awareness of insulin-like growth factor-2 (IGF2) mechanisms emphasiz...

Association of Systemic or Intravitreal Antivascular Endothelial Growth Factor (Anti-VEGF) and Impaired Wound Healing in Pediatric Patients: Collagen to the Rescue.

May 06, 2021

Bevacizumab is a humanized monoclonal antibody to vascular endothelial growth factor (VEGF) that has been used as a systemic chemotherapy treatment of various malignancies in adults since 2000. It has...

Pilot Study of Clinician-Patient Collaboration in Glaucoma.

May 06, 2021

This pilot study was undertaken to examine the feasibility of a larger scale trial examining the effect of interventions to improve patient-clinician collaboration. The primary outcome was the extent ...

Prospects for the application of Müller glia and their derivatives in retinal regenerative therapies.

May 03, 2021

Neural cell death is the main feature of all retinal degenerative disorders that lead to blindness. Despite therapeutic advances, progression of retinal disease cannot always be prevented, and once ne...

The Spectrum of Maculopathy in Mitochondrial DNA A3243G Mutation: A Case Series of Six Patients.

May 03, 2021

The mitochondrial DNA (mtDNA) A3243G point mutation encompasses a heterogenous group of disorders including mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), maternally ...

Clinical Classification of Acquired Concomitant Esotropia.

May 03, 2021

Classification and management of acquired concomitant esotropia is controversial. We sought to establish a simple clinical classification in order to determine in which cases further investigations in...

Characteristics of progressive temporal visual field defects in patients with myopia.

May 03, 2021

Temporal visual field damage (VFD) is the common type of non-glaucomatous VF defects found in eyes with myopia. However, little is known about the factors associated with its progression. We investiga...

Computerised dynamic posturography for postural control assessment in subjects wearing multifocal contact lenses dedicated for myopia control.

May 03, 2021

To measure body balance using computerised dynamic posturography in young adults wearing multifocal contact lenses (MFCL) with high addition powers designed for myopia control.Twenty-four young adults...

Optimization of goblet cell density quantification methods.

May 03, 2021

The purpose of this study was to develop a standardized, accurate and efficient method for estimating conjunctival goblet cell density (GCD) via optimizing sample storage conditions and quantification...

Inducing dry eye disease using a custom engineered desiccation system: Impact on the ocular surface including keratin-14-positive limbal epithelial stem cells.

May 03, 2021

Dry eye disease (DED) is characterized by loss of tear film stability that becomes self-sustaining in a vicious cycle of pathophysiological events. Currently, desiccation stress (DS) is the dominant p...

Neuropathic corneal pain and dry eye: a continuum of nociception.

May 03, 2021

Throughout the body, damage to peripheral nerves normally involved in nociception may produce a constellation of symptoms-including irritation, itchiness and pain. The neurobiological processes involv...

Neurovascular unit in diabetic retinopathy: pathophysiological roles and potential therapeutical targets.

May 03, 2021

Diabetic retinopathy (DR), one of the common complications of diabetes, is the leading cause of visual loss in working-age individuals in many industrialized countries. It has been traditionally regar...

Plasma miR-26a-5p is a biomarker for retinal neurodegeneration of early diabetic retinopathy.

May 03, 2021

Retinal neurodegeneration is an early pathological change in diabetic retinopathy (DR). Early-stage retinal neurodegeneration is usually asymptomatic. This study aims to identify circulating microRNAs...

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