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Ophthalmology General

Elevated dimethylarginine, ATP, cytokines, metabolic remodeling involving tryptophan metabolism and potential microglial inflammation characterize primary open angle glaucoma.

May 10, 2021

Glaucoma of which primary open angle glaucoma (POAG) constitutes 75%, is the second leading cause of blindness. Elevated intra ocular pressure and Nitric oxide synthase (NOS) dysfunction are hallmarks...

The Risks and Benefits of Myopia Control.

May 10, 2021

The prevalence of myopia is increasing around the world, stimulating interest in methods to slow its progression. The primary justification for slowing myopia progression is to reduce the risk of visi...

Prediction of postoperative refractive astigmatism before toric intraocular lens implantation.

May 10, 2021

To determine the preoperative factors influencing refractive astigmatism after cataract surgery for astigmatism correction by toric intraocular lens (IOL) implantation and to evaluate the prediction m...

Quantitative proteomic analysis of scleras in guinea pig exposed to wavelength defocus.

May 10, 2021

Myopia is the most common optical disorder in the world, and wavelength defocus induced ametropia and myopia have attracted great attention. The objective was to identify and quantify scleral proteins...

Trehalose/sodium hyaluronate eye drops in post-cataract ocular surface disorders.

May 10, 2021

Prospective, randomised, open-label, comparative study to evaluate efficacy of trehalose/sodium hyaluronate eye drops for post-operative discomfort and tear film stability in patients undergoing catar...

Ophthalmologic findings and complications before and after hematopoietic stem cell transplantation: single-center study.

May 10, 2021

Different and various system complications and late effects may occur after hematopoietic stem cell transplantation (HSCT). It was aimed to obtain information about the frequency of ophthalmologic com...

Clinical practice patterns in the management of dry eye disease: A TFOS international survey.

May 10, 2021

To examine clinical management and prescribing patterns for dry eye disease (DED), in relation to severity and subtype, by eyecare practitioners across the globe.An online-anonymous cross-sectional su...

Obesity and risk of age-related eye diseases: a systematic review of prospective population-based studies.

May 10, 2021

Obesity is a public health challenge worldwide. The relationship between obesity and age-related eye diseases including cataract, glaucoma, age-related macular degeneration (AMD) and diabetic retinopa...

Remnant cholesterol predicts progression of diabetic nephropathy and retinopathy in type 1 diabetes.

May 10, 2021

We aimed to assess whether remnant cholesterol concentration and variability predict the progression of diabetic nephropathy (DN) and severe diabetic retinopathy (SDR) in type 1 diabetes.This observat...

Amelioration of diabetic retinopathy in db/db mice by treatment with different proportional three active ingredients from Tibetan medicine Berberis dictyophylla F.

May 10, 2021

Berberis dictyophylla F., a famous Tibetan medicine, has been used to prevent and treat diabetic retinopathy (DR) for thousands of years in clinic. However, its underlying mechanisms remain unclear.Th...

Inter-eye relationship of intraocular pressure change after unilateral trabeculectomy, filtering canaloplasty, or PreserFlo™ microshunt implantation.

May 10, 2021

This study assesses short-term intraocular pressure (IOP) change in the fellow eye of glaucoma patients after mitomycin C-augmented trabeculectomy, filtering canaloplasty, or PreserFlo™ microsh...

Joint optic disc and optic cup segmentation based on boundary prior and adversarial learning.

May 10, 2021

The most direct means of glaucoma screening is to use cup-to-disc ratio via colour fundus photography, the first step of which is the precise segmentation of the optic cup (OC) and optic disc (OD). In...

New Compound Heterozygous CYP4V2 Mutations in Bietti Crystalline Corneoretinal Dystrophy.

May 10, 2021

Bietti crystalline corneoretinal dystrophy (BCD) is an autosomal recessive retinal dystrophy which is caused by the mutations of CYP4V2, usually progressing to legal blindness by the 5th or 6th decade...

Patient and Resource Management of Emergency Walk-In Clinic During a COVID-19 Pandemic State Lockdown.

May 10, 2021

To gather data on the most common chief complaints, diagnoses, in-office procedures, and surgeries that presented to the Kresge Eye Institute's Emergency Clinic in Detroit, Michigan during the COVID-1...

Diagnostic accuracy of current machine learning classifiers for age-related macular degeneration: a systematic review and meta-analysis.

May 10, 2021

The objective of this study was to systematically review and meta-analyze the diagnostic accuracy of current machine learning classifiers for age-related macular degeneration (AMD). Artificial intelli...

Postoperative Photoreceptor Integrity in Retinal Detachment Repair

May 06, 2021

Pneumatic retinopexy (PnR) is a condition associated with reduced vertical metamorphosis and greater visual acuity compared to pars plana vitrectomy (PPV) for primary rhegmatogenous retinal detachment...

Racial/Ethnic Disparities in Ophthalmology Clinical Trials

May 06, 2021

Representative and diverse enrollment in pivotal clinical trials is crucial for adequately powering subgroup analysis and ensuring credibility, equity, and validity of the results. This study aims to ...

Priming human adipose-derived mesenchymal stem cells for corneal surface regeneration.

May 06, 2021

Limbal stem cells (LSC) maintain the transparency of the corneal epithelium. Chemical burns lead the loss of LSC inducing an up-regulation of pro-inflammatory and pro-angiogenic factors, triggering co...

Strehl Ratio and Myopia in Chinese Adolescents: The Tuyou County Pediatric Eye (TYPE) Study.

May 06, 2021

To investigate the relationships between property of the visual quality, Strehl ratio (SR) and the degree of myopia.A total of 444 anatomically normal eyes of 222 adolescents were enrolled in the TYPE...

Axial length targets for myopia control.

May 06, 2021

Both emmetropic and myopic eyes elongate throughout childhood. The goals of this study were to compare axial elongation among untreated progressing myopes, progressing myopes treated with a myopia con...