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Ophthalmology General

Longitudinal Development of Refractive Error in Children Treated With Intravitreal Bevacizumab or Laser for Retinopathy of Prematurity.

May 20, 2021

To compare the patterns of longitudinal refractive error development during the first 3.5 years in children with severe retinopathy of prematurity (ROP) treated with intravitreal bevacizumab (IVB) or ...

Improvement of Evaporative Dry Eye With Meibomian Gland Dysfunction in Model Mice by Treatment With Ophthalmic Solution Containing Mineral Oil.

May 20, 2021

Meibomian gland dysfunction (MGD) is a major cause of evaporative dry eye. The purpose of this study is to assess the efficacy of a mineral oil-containing ophthalmic solution (MO) in mitigating the ev...

Smart Eye Camera: A Validation Study for Evaluating the Tear Film Breakup Time in Human Subjects.

May 20, 2021

This study aimed to demonstrate the efficacy of a "Smart Eye Camera (SEC)" in comparison with the efficacy of the conventional slit-lamp microscope by evaluating their diagnostic functionality for dry...

A Novel Rabbit Dry Eye Model Induced by a Controlled Drying System.

May 20, 2021

To establish an environment-induced dry eye model in rabbits using a controlled drying system (CDS).Rabbits were randomly divided into two groups. The rabbits in the dry group were housed in the CDS, ...

Sex-Based Analysis of Potential Inflammation-Related Protein Biomarkers in the Aqueous Humor of Patients With Diabetes Mellitus.

May 20, 2021

To investigate whether men have higher inflammatory protein biomarker concentrations in their aqueous humor (AH) compared with women in groups of patients with varying levels of diabetic disease.This ...

Validation of a Diagnostic Support System for Diabetic Retinopathy Based on Clinical Parameters.

May 20, 2021

To validate a clinical decision support system (CDSS) that estimates risk of diabetic retinopathy (DR) and to personalize screening protocols in type 2 diabetes mellitus (T2DM) patients.We utilized a ...

Spleen Tyrosine Kinase Mediates Microglial Activation in Mice With Diabetic Retinopathy.

May 20, 2021

Diabetic retinopathy (DR) is a leading cause of blindness in developed countries, in which microglial activation is involved. However, the mechanism of microglial activation in DR remains largely unkn...

High-Pass Visual Acuity Loss and Macular Structure-Function Relationship in Patients With Primary Open-Angle Glaucoma.

May 20, 2021

The Logarithm of the Minimum Angle of Resolution (logMAR) chart is the most common clinical test for assessing central visual function in glaucoma. However, based on the use of these charts, visual ac...

Assessment of Generative Adversarial Networks for Synthetic Anterior Segment Optical Coherence Tomography Images in Closed-Angle Detection.

May 20, 2021

To develop generative adversarial networks (GANs) that synthesize realistic anterior segment optical coherence tomography (AS-OCT) images and evaluate deep learning (DL) models that are trained on rea...

Loss of PRSS56 function leads to ocular angle defects and increased susceptibility to high intraocular pressure.

May 20, 2021

Glaucoma is a leading cause of blindness affecting up to 70 million people worldwide. High intraocular pressure (IOP) is a major risk factor for glaucoma. Inefficient aqueous humor (AqH) outflow resul...

Building supply chain capacity for neglected tropical diseases: experience from the Ascend West and Central Africa programme.

May 17, 2021

The Ascend West and Central Africa programme, funded by the UK Foreign, Commonwealth and Development Office (FCDO) is supporting integrated preventative chemotherapy for up to five neglected tropical ...

Functional connexin35 increased in the myopic chicken retina.

May 17, 2021

Our previous research showed that increased phosphorylation of connexin (Cx)36 indicated extended  coupling of AII amacrine cells (ACs) in the rod-dominant mouse myopic retina. This research will det...

Marfan syndrome with recurrent lower left posterior toothache as the first symptom: A report on a rare case.

May 17, 2021

Marfan syndrome (MFS) is a life-threatening connective tissue disorder that affects multiple organs and systems. We report a case of MFS with recurrent lower left posterior toothache as the first symp...

One-year results of the Variation of Orthokeratology Lens Treatment Zone (VOLTZ) Study: a prospective randomised clinical trial.

May 17, 2021

To present the 1-year results of the Variation of Orthokeratology Lens Treatment Zone (VOLTZ) Study, which aims to investigate the myopia control effect of orthokeratology (ortho-k) lenses with differ...

Comparative Study of Dry Eye Indices Following Cataract Surgery.

May 17, 2021

This study aims to assess dry eye indices following cataract surgery.A single center descriptive and comparative study was performed. A total of 100 eyes of 100 cases fulfilling the inclusion criteria...

Ocular surface complications result from dysregulation of the OGF-OGFr signaling pathway in female diabetic rats.

May 17, 2021

Approximately 4.5 million women in the United States exhibit diabetes-associated ocular complications. The time course and magnitude of these complications, and their association with the dysregulatio...

Neurotrophic keratopathy and refractive surgery.

May 17, 2021

Corneal nerve function is an important consideration for the refractive surgeon. In patients without a history of neuropathy, refractive surgery can lead to destruction of corneal nerves and may predi...

Catastrophic, Bilateral Retinal Vascular Occlusion after Intravitreal Bevacizumab Injection.

May 17, 2021

To describe two cases of catastrophic, bilateral retinal vascular occlusion following intravitreal (IVT) bevacizumab injection.Case series. Main outcome measures included clinical and fluorescein angi...

Barriers to initiating SGLT2 inhibitors in diabetic kidney disease: a real-world study.

May 17, 2021

Sodium-glucose cotransporter 2 inhibitor (SGLT2i) should be considered for patients with type 2 diabetes (T2D) and chronic kidney disease (CKD) having estimated glomerular filtration rate (eGFR) ≥...

Impact of low luminance conditions on quality of life for the visually impaired: development of the Low Luminance Questionnaire Japanese version.

May 17, 2021

This study aimed to develop a Japanese version of the Low Luminance Questionnaire (LLQ-J) and to evaluate its reliability and validity.Cross-sectional study.LLQ-J was developed by standardized methods...