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Ophthalmology General

Diabetic retinopathy classification based on multipath CNN and machine learning classifiers.

May 27, 2021

Eye care professionals generally use fundoscopy to confirm the occurrence of Diabetic Retinopathy (DR) in patients. Early DR detection and accurate DR grading are critical for the care and management ...

Health-related quality of life associated with diabetic retinopathy in patients at a public primary care service in southern Brazil.

May 27, 2021

This study aimed to establish the utility values of different health states associated with diabetic retinopathy in a Brazilian sample to provide input to model-based economic evaluations.This cross-s...

Ophthalmic Disease Detection via Deep Learning With A Novel Mixture Loss Function.

May 27, 2021

With the popularization of computer-aided diagnosis (CAD) technologies, more and more deep learning methods are developed to facilitate the detection of ophthalmic diseases. In this article, the deep ...

Evaluation of the Cirrus HD-OCT Normative Database Probability Codes in an African American Population.

May 27, 2021

Race-adjusted interpretation of data from Cirrus high-definition optical coherence tomography (HD-OCT) devices is not standard practice. The aim of this study is to evaluate differences in peripapilla...

Hiding in Plain Sight: Genetic Deaf-Blindness is not Always Usher Syndrome.

May 24, 2021

Hearing loss (HL) is the most common congenital sensory impairment. Usher syndrome (USH) is the leading genetic etiology of congenital deafness combined with progressive vision loss, and individuals p...

Investigation of Macular Choroidal Thickness and Blood Flow Change by Optical Coherence Tomography Angiography After Posterior Scleral Reinforcement.

May 24, 2021

This work aimed to study the effect of posterior scleral reinforcement (PSR) on choroidal thickness (CT) and blood flow. This study included 25 eyes of 24 patients with high myopia ( ≤ -6.0 dioptr...

Ratio of torus and equivalent power to refractive cylinder and spherical equivalent in phakic lenses - a Monte-Carlo simulation study.

May 24, 2021

Spherical and astigmatic powers for phakic intraocular lenses are frequently calculated using fixed ratios of phakic lens refractive power to refractive spherical equivalent, and of phakic lens astigm...

Biophysical Properties of Corneal Cells Reflect High Myopia Progression.

May 24, 2021

Myopia is a common ocular disorder with significant alterations in the anterior ocular structure, including the cornea. The cell biophysical phenotype has been proposed to reflect the state of various...

Assessment of four validated questionnaires for screening of dry eye disease in an African cohort.

May 24, 2021

To evaluate the 5-item dry eye questionnaire (DEQ-5) for measurement precision and unidimensionality, and assess the ability of Ocular Surface Disease Index (OSDI), McMonnies Dry Eye Questionnaire (MQ...

The role of KPI-121 0.25% in the treatment of dry eye disease: penetrating the mucus barrier to treat periodic flares.

May 24, 2021

The tear film, which includes mucins that adhere to foreign particles, rapidly clears allergens and pathogens from the ocular surface, protecting the underlying tissues. However, the tear film's abili...

Ocular Involvement in COVID-19: Conjunctivitis and More.

May 24, 2021

Since the beginning of 2020, SARS-CoV-2, the pathogen of COVID-19, has led to a global pandemic that also affects ophthalmology. Ophthalmologists can be confronted at any time with potentially COVID-1...

Delay in seeking medical care after the onset of symptoms in patients with sight-threatening diabetic retinopathy.

May 24, 2021

To investigate the reasons for delays in seeking medical care in patients with diabetic retinopathy and associated risk factors.We retrospectively reviewed data for patients with sight-threatening dia...

HIF1α-PFKFB3 Pathway’s Role In Diabetic Retinopathy

May 24, 2021

Diabetic retinopathy (DR) is the leading cause of blindness in adults of developed countries. Both microvasculopathy and neurodegeneration are implicated in mechanisms of DR development, with neuronal...

Neuroprotective role of sphingolipid rheostat in excitotoxic retinal ganglion cell death.

May 24, 2021

The glutamate excitotoxicity has been suggested as a factor involved in the loss of retinal neuronal cells, including retinal ganglion cell (RGC), in various retinal degenerative diseases including is...

Human RGR Gene and Associated Features of Age-related Macular Degeneration Revealed in Models of Retina-Choriocapillaris Atrophy.

May 24, 2021

Age-related macular degeneration (AMD) is a progressive degenerative eye disease that is the most common cause of blindness among elderly humans. AMD is characterized by early atrophy of the choriocap...

Gamma sterilization and in vivo evaluation of cationic nanostructured lipid carriers as potential ocular delivery systems for antiglaucoma drugs.

May 24, 2021

Solid lipid nanoparticles and nanostructured lipid carriers showed promising results for enhancement of ocular bioavailability of drugs with poor corneal permeability. One of these drugs is methazolam...

Genetic Analysis in a Swiss Cohort of Bilateral Congenital Cataract.

May 24, 2021

Identification of geographic population-based differences in genotype and phenotype heterogeneity are important for targeted and patient-specific diagnosis and treatment, counseling, and screening str...

Corneal Application of R9-SOCS1-KIR Peptide Alleviates Endotoxin-Induced Uveitis.

May 20, 2021

Uveitis is an ocular inflammation that can affect individuals of all ages and is a major cause of blindness. We have tested the therapeutic efficacy of a cell penetrating peptide from the kinase inhib...

Effect of Scleral Crosslinking Using Multiple Doses of Genipin on Experimental Progressive Myopia in Tree Shrews.

May 20, 2021

To evaluate the effect of scleral crosslinking (SXL) on slowing experimental progressive myopia in tree shrew eyes using sub-Tenon's injections of genipin (GEN) at different concentrations and number ...

Association Between the Types of Posterior Staphyloma and Their Risk Factors in Pathological Myopia.

May 20, 2021

The purpose of this study was to investigate the relationship of posterior staphyloma (PS) types in pathological myopia (PM) with age, best-corrected visual acuity (BCVA), spherical equivalent (SE), a...