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Ophthalmology General

A core-shell nanoplatform as a nonviral vector for targeted delivery of genes to the retina.

Aug 02, 2021

Retinal diseases, including age-related macular degeneration (AMD), are a major cause of blindness. Efficient delivery of therapeutic genes to retinal cells to treat retinal disease is a formidable ch...

Using electronic health records to develop and validate a machine-learning tool to predict type 2 diabetes outcomes: a study protocol.

Aug 02, 2021

Type 2 diabetes mellitus (T2DM) is a major cause of blindness, kidney failure, myocardial infarction, stroke and lower limb amputation. We are still unable, however, to accurately predict or identify ...

A Novel Stimuli-Responsive Injectable Antibacterial Hydrogel to Achieve Synergetic Photothermal/Gene-Targeted Therapy towards Uveal Melanoma.

Aug 02, 2021

Uveal melanoma (UM) is the most prevalent primary intraocular malignant tumor with a high lethal rate. Patients who undergo conventional enucleation treatments consistently suffer permanent blindness,...

Prevalence and time trends of refractive error in Chinese children: A systematic review and meta-analysis.

Aug 02, 2021

To investigate the prevalence and time trends of refractive error (RE) among Chinese children under 18 years old.PubMed, Embase, Web of Science were searched for articles that estimated prevalence of ...

Multiple Evanescent White Dot Syndrome (MEWDS) Associated with Progression of Lacquer Cracks in High Myopia.

Aug 02, 2021

To report a case of multiple evanescent white dot syndrome (MEWDS) associated with acute progression of lacquer cracks in high myopia.A 41-year-old female patient with high myopia developed typical si...

Biomechanics of Ophthalmic Crosslinking.

Aug 02, 2021

Crosslinking involves the formation of bonds between polymer chains, such as proteins. In biological tissues, these bonds tend to stiffen the tissue, making it more resistant to mechanical degradation...

Clinical evaluation of meibomian gland dysfunction in patients with keratoconus.

Aug 02, 2021

To investigate the association of keratoconus (KC) with meibomian gland dysfunction (MGD) and to describe the epidemiological characteristics of MGD in this disease.In this observational study, 120 KC...

The ocular surface findings in alopecia areata patients: clinical parameters and impression cytology.

Aug 02, 2021

The objective of this study was to examine the effects of alopecia areata (AA) on the ocular surface and conjunctival cytology.A total of 48 subjects were included in the present study. Twenty-three s...

Tear metabolomics highlights new potential biomarkers for differentiating between Sjögren's syndrome and other causes of dry eye.

Aug 02, 2021

The lacrimal exocrinopathy of primary Sjögren's syndrome (pSS) is one of the main causes of severe dry eye syndrome and a burden for patients. Early recognition and treatment could prevent irreversib...

Association between Dietary Choline Intake and Diabetic Retinopathy: National Health and Nutrition Examination Survey 2005-2008.

Aug 02, 2021

To explore whether there is an association between dietary choline intake and odds of diabetic retinopathy (DR) in the US diabetic population.A cross-sectional study was conducted using the combined d...

Multi-label classification of fundus images based on graph convolutional network.

Aug 02, 2021

Diabetic Retinopathy (DR) is the most common and serious microvascular complication in the diabetic population. Using computer-aided diagnosis from the fundus images has become a method of detecting r...

Five regions, five retinopathy screening programmes: a systematic review of how Portugal addresses the challenge.

Aug 02, 2021

The implementation of a population-based screening programme for diabetic retinopathy involves several challenges, often leading to postponements and setbacks at high human and material costs. Thus, i...

PRESERFLO™ MicroShunt versus trabeculectomy: first results on efficacy and safety.

Aug 02, 2021

To report efficacy and safety outcomes of the PRESERFLO™ MicroShunt compared with trabeculectomy, the current gold-standard treatment for advanced glaucoma, in the early and intermediate postop...

Incidence of ocular hypertension in patients receiving intravitreal anti-VEGF injections: comparing filtered drug in plastic silicone-free syringes to nonfiltered drug in silicone-lined insulin plastic syringes.

Aug 02, 2021

To examine the difference in incidence of ocular hypertension (OHT) following the introduction of filtered anti-vascular endothelial growth factor (anti-VEGF) medication in silicone-free syringes.Retr...

Cyclodextrin-based formulation of carbonic anhydrase inhibitors for ocular delivery - A review.

Aug 02, 2021

Carbonic anhydrase inhibitors (CAIs) are used as systemic and topical agents for lowering intraocular pressure (IOP) in patients with glaucoma. Owing to the wide distribution of CAs and their physiolo...

Microbial Contamination of Extended Use Ophthalmic Drops in Ophthalmology Clinic.

Aug 02, 2021

The objectives of this study were to determine the prevalence of microbial contamination of multi-user preserved ophthalmic drops (POD) in Ophthalmology Outpatient Clinic (OOC), to compare the rate of...

Recommendations for Dosing & Administering Medical Cannabis for Chronic Pain

Jul 31, 2021

Despite a need for more robust evidence, many patients with chronic pain are being treated with medical cannabis and cannabinoids. In the Journal of Cannabis Research, the Global Task Force on Dosing ...

Nrf2 deficiency decreases NADPH from impaired IDH shuttle and pentose phosphate pathway in retinal pigmented epithelial cells to magnify oxidative stress-induced mitochondrial dysfunction.

Jul 29, 2021

The nuclear factor-erythroid 2-related factor-2 (Nrf2), a major antioxidant transcription factor, is decreased in several age-related diseases including age-related macular degeneration (AMD), the mos...

Outcomes of toric IOL implantation guided by iris-registered femtosecond laser capsulotomy markings.

Jul 29, 2021

To assess the accuracy and stability of iris-registered femtosecond laser-assisted anterior capsule axis markings (compensating cyclotorsion) along with refractive and visual outcomes after toric IOL ...

Carbon myopia: the urgent need for integrated social, economic and environmental action in the livestock sector.

Jul 29, 2021

Livestock have long been integral to food production systems, often not by choice but by need. While our knowledge of livestock greenhouse gas emissions (GHG) mitigation has evolved, the prevailing fo...