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Ophthalmology General

Cone photoreceptor density in the Copenhagen Child Cohort at age 16-17 years.

Sep 27, 2021

To examine cone density in relation to gestational and morphological parameters in the Copenhagen Child Cohort (CCC2000).The macula was imaged using adaptive optics in 1,296 adolescents aged 16-17 ye...

Evaluation of the Ocular Surface, Conjunctival Impression Cytology and Meibomian Gland Dropout in Patients with Familial Mediterranean Fever.

Sep 27, 2021

Familial Mediterranean fever (FMF) is an idiopathic disease with chronic inflammation. We aimed to determine the changes caused by the chronic inflammatory nature of FMF on the ocular surface, meibomi...

Downregulation of acylglycerol kinase suppresses high glucose-induced endothelial-mesenchymal transition in HRECs through regulating the LPAR1/TGF-β/Notch signaling pathway.

Sep 27, 2021

The endothelial-mesenchymal transition (EndMT) participates in the progression of diabetic retinopathy (DR), but cell-intrinsic factors modulating this process remain elusive. In this study, we explor...

The dynamic optotype (Dyop): a novel visual acuity test for use in children.

Sep 27, 2021

To evaluate the "dynamic optotype" (Dyop), a simple visual acuity test based on a dynamic target that requires minimal knowledge of symbols and letters.A total of 160 consecutive, systemically healthy...

Visual Outcomes in Eyes with Neovascular Glaucoma and Anterior Segment Neovascularization Without Glaucoma.

Sep 27, 2021

To find predictive factors of neovascular glaucoma (NVG) development in anterior segment neovascularization without glaucoma (ASNVWG) and poor visual outcomes in eyes that have already developed NVG.R...

Quality of life in adults with childhood glaucoma: An interview study.

Sep 27, 2021

To explore and report on the quality of life (QoL) issues encountered by adults with childhood glaucoma.Exploratory qualitative study.Forty-seven participants with childhood glaucoma (defined as disea...

Retinal Capillary Basement Membrane

Sep 21, 2021

This study states that the Vascular basement membrane (BM) thickening has been hailed over half a century as the most prominent histological lesion in diabetic microangiopathy, and represents an early...

Compound heterozygous mutations in the LTBP2 gene associated with microspherophakia in a Chinese patient: a case report and literature review.

Sep 20, 2021

Microspherophakia (MSP, OMIM 251,750) is a rare inherited autosomal recessive eye disorder characterized by small spherically shaped lens. Several studies have indicated that the transforming growth...

Compound heterozygous KCNV2 variants contribute to cone dystrophy with supernormal rod responses in a Chinese family.

Sep 20, 2021

Cone dystrophy with supernormal rod response (CDSRR) is an autosomal recessive retinal disorder characterized by myopia, dyschromatopsia, nyctalopia, photophobia, and nystagmus. CDSRR is caused by mut...

Emerging therapeutic opportunities for integrin inhibitors.

Sep 20, 2021

Integrins are cell adhesion and signalling proteins crucial to a wide range of biological functions. Effective marketed treatments have successfully targeted integrins αIIbβ3, α4β7/α4β1 and αLÎ...

Effect of ethnicity and other sociodemographic factors on attendance at diabetic eye screening: a 12-month retrospective cohort study.

Sep 20, 2021

To examine the association of sociodemographic characteristics with attendance at diabetic eye screening in a large ethnically diverse urban population.Retrospective cohort study.Screening visits in t...

Sight-threatening retinopathy in 9 adolescents with early-onset type 1 diabetes.

Sep 20, 2021

In adults, there has been a decline in the incidence of diabetic retinopathy associated with improvements in diabetes management. Data on incident severe diabetic retinopathy in adolescents are sparse...

Juvenile-onset Open-angle Glaucoma - A Clinical and Genetic Update.

Sep 20, 2021

Juvenile-onset open-angle glaucoma (JOAG) is a subset of primary open-angle glaucoma that is diagnosed before 40 years of age. The disease may be familial or non-familial, with proportions varying amo...

A Genotype-Phenotype Analysis of the Bardet-Biedl Syndrome in Puerto Rico.

Sep 20, 2021

Bardet-Biedl syndrome is a complex heterogeneous ciliopathy caused by genetic mutations. Although establishing genotype-phenotype correlations has been challenging, some regional variations have been ...

Gene therapy: perspectives from young adults with Leber's congenital amaurosis.

Sep 20, 2021

To investigate Leber congenital amaurosis (LCA) patients' expectations, decision-making processes and gene therapy-related concerns.Using a qualitative approach, we explored perceptions of gene therap...

Outcomes of Cataract Surgeries Performed in Makeshift Operating Rooms in Rural Camps, Compared to Hospital-based Surgeries in Nepal.

Sep 13, 2021

This study was undertaken to evaluate the complication rates and visual outcomes of outreach cataract surgeries done in makeshift operating rooms.In this retrospective study, surgical outcomes of cons...

Deep feed forward neural network-based screening system for diabetic retinopathy severity classification using the lion optimization algorithm.

Sep 13, 2021

Diabetic Retinopathy (DR) has become a major cause of blindness in recent years. Diabetic patients should be screened on a regular basis for early detection, which can help them avoid blindness. Furth...

EFFECT OF PHARMACOLOGICAL PUPIL DILATION ON INTRAOCULAR LENS POWER CALCULATION IN PATIENTS INDICATED FOR CATARACT SURGERY.

Sep 13, 2021

To evaluate the influence of pupil dilation on ocular parameters measured by optical biometry and the influence of pupil dilation on intraocular lens (PC IOL) power calculation by using the third-gene...

Magnitude of astigmatism - A comparison between eyes.

Sep 13, 2021

Astigmatism is a highly prevalent refractive error and while studies typically focus to describe the axis symmetry between eyes, little is known about the refractive symmetry. Therefore, this study de...

Impact of residual astigmatism and defocus in eyes with trifocal intraocular lenses.

Sep 13, 2021

To assess the impact on visual function of different residual astigmatic situations combined with 0.50D negative defocus at different distances in patients with trifocal intraocular lenses (IOLs).ClĂ­...

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