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Ophthalmology General

Long-term Efficacy of a Treat-and-Extend Regimen With Ranibizumab in Patients With Neovascular Age-Related Macular Disease: An Open-label 12-month Extension to the CANTREAT Study.

Jan 03, 2022

To assess the long-term effectiveness of a treat-and-extend (T&E) anti-vascular endothelial growth factor regimen in patients with neovascular age-related macular degeneration who remain on T&...

The role of microRNAs in glaucoma.

Jan 03, 2022

In this review, we aim to provide a comprehensive summary of the various microRNAs (miRNAs) shown to be involved in glaucoma and intraocular pressure regulation. miRNAs are short, single-stranded, and...

Mitochondrial Dysfunction in Primary Open-angle Glaucoma Characterized by Flavoprotein Fluorescence at the Optic Nerve Head.

Jan 03, 2022

To investigate the presence of flavoprotein fluorescence (FPF) at the optic nerve head (ONH) rim as a marker of mitochondrial dysfunction in primary open-angle glaucoma (POAG) and control eyes.Retrosp...

Botulinum Toxin for the Treatment of Hemifacial Spasm: An Update on Clinical Studies.

Dec 27, 2021

Hemifacial spasm (HFS) is a movement disorder characterized by involuntary contractions of the facial muscles innervated by the seventh cranial nerve. Generally, it is associated with a poor quality o...

Progression of myopia in teenagers and adults: a nationwide longitudinal study of a prevalent cohort.

Dec 27, 2021

The prevalence of myopia is increasing worldwide. The purpose of this study was to evaluate the progression of myopia in teenagers and adults in France.This nationwide prospective study followed 630â€...

The Association of Choroidal Thickening by Atropine with Treatment Effects for Myopia: Two-Year Clinical Trial of the LAMP Study.

Dec 27, 2021

To evaluate longitudinal changes in subfoveal choroidal thickness (SFChT) among children receiving 0.05%, 0.025%, 0.01% atropine over two-years and their associations with treatment outcomes in myopia...

Mean Tear-Film Lipid Layer Thickness and Video Display Terminal Time as Risk Factors for Abnormal Blinking in Children.

Dec 27, 2021

To explore the risk factors for abnormal blinking in children and the role of the tear-film lipid layer thickness (LLT) as a function of duration of video display terminal (VDT) use in children. Chi...

Formulation and development of tacrolimus-gellan gum nanoformulation for treatment of dry eye disease.

Dec 27, 2021

The present study aimed at the development and evaluation of tacrolimus gellan gum nanoparticles (TGNPs) for the effective management of dry eye disease (DED) following topical application. TGNPs were...

Phase 1 Dose-Escalation Study of Plasma Kallikrein Inhibitor THR-149 for the Treatment of Diabetic Macular Edema.

Dec 27, 2021

The purpose of this study was to evaluate the safety and preliminary efficacy of a single intravitreal injection of 3 dose levels of THR-149 in adults with center-involved diabetic macular edema (DME)...

The effect of psychotherapy on anxiety, depression, and quality of life in patients with diabetic retinopathy: A protocol for systematic review and network meta-analysis.

Dec 27, 2021

Diabetic retinopathy (DR) is one of the common microvascular complications in diabetic patients, which is characterized by progressive development and often leads to irreversible visual impairment. Mo...

Periocular Adverse Reactions to Omidenepag Isopropyl: Periocular Adverse Reactions to Omidenepag Isopropyl.

Dec 27, 2021

To investigate the periocular adverse reactions to omidenepag isopropyl (OMDI).Non-randomized comparative clinical study.We enrolled 100 patients (100 eyes) with primary open-angle glaucoma or ocular ...

Performances of machine learning in detecting glaucoma using fundus and retinal optical coherence tomography images: A meta-analysis.

Dec 27, 2021

To evaluate the performance of machine learning (ML) in detecting glaucoma using fundus and retinal optical coherence tomography (OCT) images.Meta-analysis.PubMed and EMBASE were searched on August 11...

Limitations in cataract surgical services for children in Ethiopia: a nationwide survey of pediatric cataract surgeons.

Dec 27, 2021

Bilateral cataract is a significant cause of blindness in children in Ethiopia. This study aimed to identify the resources available for cataract surgery in children, and to assess current surgical pr...

Perceptions of Respect From Clinicians by Patients in Racial and Ethnic Minority Groups With Eye Disease.

Dec 20, 2021

The perception of being treated with respect by clinicians may be a driver of disparities in individuals in racial and ethnic minoritie groups with eye diseases. Understanding these drivers may help i...

Visual and Refractive Outcomes of Toric Implantable Collamer Lens Implantation in Stable Keratoconus After Combined Topography-Guided PRK and CXL.

Dec 20, 2021

To evaluate the safety and efficacy of toric implantable Collamer lens (ICL) (STAAR Surgical) implanted at least 6 months after combined topography-guided photorefractive keratotomy (TG-PRK) and corne...

Effect of Central Corneal Thickness on Corneal Higher Order Aberrations After Cataract Surgery.

Dec 20, 2021

To investigate the changes of corneal higher order aberrations (HOAs) before and after phacoemulsification in patients with different central corneal thickness (CCT).In this retrospective non-randomiz...

Incidence and Risk Factors of Dry Eye in Children and Adolescents With Diabetes Mellitus: A 3-Year Follow-Up Study.

Dec 20, 2021

To investigate the incidence and risk factors of dry eye in children with diabetes mellitus (DM) over a period of 3 years. Children and adolescents with DM (age: 3-14 years) from the Shanghai Childr...

Meibomian Gland Morphology Changes After Cataract Surgery: A Contra-Lateral Eye Study.

Dec 20, 2021

To evaluate the morphology changes of meibomian glands (MGs) after cataract surgery. Hangzhou Branch of the Eye Hospital of Wenzhou Medical University, Zhejiang, China. In this contra-lateral eye s...

[Smartphone-based fundus imaging: applications and adapters].

Dec 20, 2021

Smartphone-based fundus imaging (SBFI) is an innovative and low-cost alternative for color fundus photography. Since the first reports on this topic more than 10 years ago a large number of studies ...

Development and optimization of Riluzole-loaded biodegradable nanoparticles incorporated in a mucoadhesive in situ gel for the posterior eye segment.

Dec 20, 2021

Riluzole-loaded PLGA nanoparticles (RLZ-NPs) were developed to improve the biopharmaceutical profile of RLZ after ocular administration. Moreover, RLZ-NPs were dispersed in an in situ gelling system (...

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