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Ophthalmology General

Necroptosis Contributes to Airborne Particulate Matter-Induced Ocular Surface Injury.

Mar 07, 2022

In this study, we explored the role of necroptosis in the pathogenesis of ocular surface injury caused by airborne particulate matter (PM). Human corneal epithelial (HCE) cells and mouse ocular surfac...

The Three-Dimensional Structural Configuration of the Central Retinal Vessel Trunk and Branches as a Glaucoma Biomarker.

Mar 07, 2022

To assess whether the three-dimensional (3D) structural configuration of the central retinal vessel trunk and its branches (CRVT&B) could be used as a diagnostic marker for glaucoma.Retrospective,...

Drug induced cicatrizing conjunctivitis: A case series with review of etiopathogenesis, diagnosis and management.

Mar 07, 2022

Drug induced cicatrizing conjunctivitis (DICC) is defined as a disease in which conjunctival cicatrization develops as a response to the chronic use of inciting topical and, rarely, systemic medicatio...

Change in Medication Adherence in the Support, Educate, Empower Program: Demographic, Clinical, and Psychosocial Predictors

Feb 28, 2022

For a study, the researchers sought to determine if demographic, clinical, or psychosocial characteristics in the Support, Educate, Empower (SEE) program worked as mediators of change in medication ad...

Health Literacy and Glaucoma Drop Administration Success

Feb 28, 2022

The researchers sought to find a link between health literacy and successful glaucoma drop administration for research. A single-site interventional randomized controlled trial's design substudy was c...

Evaluations of Deep Learning Approaches for Glaucoma Screening Using Retinal Images from Mobile Device.

Feb 28, 2022

Glaucoma is a silent disease that leads to vision loss or irreversible blindness. Current deep learning methods can help glaucoma screening by extending it to larger populations using retinal images. ...

Cost-effectiveness of artificial intelligence screening for diabetic retinopathy in rural China.

Feb 28, 2022

Diabetic retinopathy (DR) has become a leading cause of global blindness as a microvascular complication of diabetes. Regular screening of diabetic retinopathy is strongly recommended for people with ...

Comparison of visual outcomes between 120-µm and 140-µm cap thicknesses 12 months after small incision lenticule extraction.

Feb 28, 2022

To compare visual and refractive outcomes as well as changes in high-order aberrations in patients with 120- versus 140-µm cap thicknesses 12 months after small incision lenticule extraction. Ninety...

Visual loss and optic neuropathy in a patient with Klinefelter's syndrome, open-angle glaucoma, vitamin B (cobalamin) and folate deficiency.

Feb 28, 2022

A 54-year-old man with Klinefelter's syndrome presented to the neuro-ophthalmology clinic with progressive painless visual blurring in the right eye over 2 years. He was receiving intramuscular testos...

Loss of serine/threonine protein kinase 25 in retinal ganglion cells ameliorates high glucose-elicited damage through regulation of the AKT-GSK-3β/Nrf2 pathway.

Feb 28, 2022

Serine/threonine protein kinase 25 (STK25) has critical importance for diabetic complications. However, whether STK25 has a link with diabetic retinopathy is not clearly understood. The damages of ret...

Multimodal image encoding pre-training for diabetic retinopathy grading.

Feb 28, 2022

Diabetic retinopathy is an increasingly prevalent eye disorder that can lead to severe vision impairment. The severity grading of the disease using retinal images is key to provide an adequate treatme...

Long term outcomes from the HORIZON randomized trial for a Schlemm's canal microstent in combination cataract and glaucoma surgery.

Feb 28, 2022

5-year results of the HORIZON trial comparing cataract surgery combined with an intracanalicular microstent to cataract surgery alone.Prospective, multicenter, controlled randomized clinical trial.Pat...

Multifaceted Amblyopia Screening with blinq, 2WIN, and PDI Check.

Feb 28, 2022

Novel devices target different facets of amblyopia risk factors (ARFs). Through birefringence, the Rebion blinq assesses binocular foveation. The Adaptica 2WIN is a multiradial infrared photorefractor...

Dexamethasone Implant for Diabetic Macular Oedema: 1-Year Treatment Outcomes from the Fight Retinal Blindness! Registry.

Feb 21, 2022

Phase III clinical trials of dexamethasone intravitreal implant for diabetic macular oedema (DMO) have reported significant improvements in visual acuity (VA). Studies evaluating the treatment of DMO...

Vector analysis of moderate to high myopic astigmatism after small-incision lenticule extraction (SMILE): 12-month follow-up.

Feb 21, 2022

To evaluate the refractive outcomes of small-incision lenticule extraction (SMILE) surgery in moderate to high myopic astigmatism.Prospective interventional case series.This study evaluated 111 eyes o...

Alterations of lower- and higher-order aberrations after unilateral horizontal rectus muscle surgery in children with intermittent exotropia: A retrospective cross-sectional study.

Feb 21, 2022

This retrospective, cross-sectional study investigated changes in corneal lower- and higher-order aberrations that cause visual disturbance after lateral rectus recession and medial rectus resection i...

Copolymer micelle-administered melatonin ameliorates hyperosmolarity-induced ocular surface damage through regulating PINK1 mediated mitophagy.

Feb 21, 2022

To investigate the role and mechanism of melatonin-loaded polymer polyvinyl caprolactam-polyvinyl acetate-polyethyleneglycol graft copolymer (PVCL-PVA-PEG) micelles (Mel-Mic) in dry eye disease (DED)....

Urinary albumin/creatinine ratio tertiles predict risk of diabetic retinopathy progression: a natural history study from the Adolescent Cardio-Renal Intervention Trial (AdDIT) observational cohort.

Feb 21, 2022

We hypothesised that adolescents with type 1 diabetes with a urinary albumin/creatinine ratio (ACR) in the upper tertile of the normal range (high ACR) are at greater risk of three-step diabetic retin...

Thioredoxin upregulation delays diabetes-induced photoreceptor cell degeneration via AMPK-mediated autophagy and exosome secretion.

Feb 21, 2022

Autophagy and exosome secretion in photoreceptor and RPE cells play an important role during diabetic retinopathy (DR). Thioredoxin (Trx) upregulation delays diabetes-induced photoreceptor cell degene...

Anti-Vascular Endothelial Growth Factor Drug Conbercept-Loaded Peptide Hydrogel Reduced Angiogenesis in the Neovascular Age-Related Macular Degeneration.

Feb 21, 2022

Age-related macular degeneration (AMD) accounts for 8.7% of the global blindness and neovascular form of AMD (nAMD) occupies a large proportion of severe visual loss and legal blindness caused by AMD ...

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