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Ophthalmology General

The effect of concentric and aspheric multifocal soft contact lenses on binocular vision in young adult myopes.

Mar 21, 2022

Multifocal soft contact lenses (MFCLs) are prescribed to inhibit myopia progression; these include aspheric and concentric designs. The effects of MFCLs on visual quality, accommodation and vergence i...

Changes in accommodation and behavioural performance with a contact lens for myopia management: A comparison between a dual-focus and a single-vision soft contact lens.

Mar 21, 2022

Dual-focus soft contact lenses for myopia management have demonstrated to be an effective strategy to reduce myopia progression. However, this optical design has been shown to alter visual quality and...

Dry Eye Symptom Severity and Visual Field Reliability Metrics.

Mar 21, 2022

Tracking failure frequency increases with dry eye symptom severity and in the left eye.Symptoms of dry eye disease are commonly encountered in glaucoma patients and can be exacerbated by topical glauc...

Serine/arginine rich protein kinase-1 (SRPK1) inhibition for the treatment of diabetic retinopathy.

Mar 21, 2022

Angiogenic VEGF isoforms are upregulated in diabetic retinopathy (DR), driving pathological growth and fluid leakage. Serine-Arginine-Rich protein kinase-1 (SRPK1) regulates VEGF splicing, and its inh...

Ophthalmology and Social Media: An In-Depth Investigation of Ophthalmologic Content on Instagram.

Mar 21, 2022

Social media has become a popular source of health information for patients. This study aimed to characterize the top-performing ophthalmologic posts on a large social media platform to better underst...

Federated learning for multi-center collaboration in ophthalmology: implications for clinical diagnosis and disease epidemiology.

Mar 21, 2022

To utilize a deep learning (DL) model trained via federated learning (FL), a method of collaborative training without sharing patient data, to delineate institutional differences in clinician diagnost...

Photo-crosslinked hydrogels for tissue engineering of corneal epithelium.

Mar 14, 2022

The vast majority of patients with corneal blindness cannot recover their vision due to the serious shortage of donor cornea. However, the technology to construct a feasible corneal substitute is a pr...

Rise of the Machines? Comparison of Cycloplegic Refraction Using Retinoscopy and the Retinomax K-Plus 5 in Children.

Mar 14, 2022

To compare the ability to detect refractive anomalies in children using automated refraction versus retinoscopic cycloplegic refraction.A pediatric population from a pediatric eye institute underwent ...

Hsa-miR-142-3p reduces collagen I in human scleral fibroblasts by targeting TGF-β1 in high myopia.

Mar 14, 2022

High myopia has been continually increasing globally until now and often results in visual impairment. Scleral extracellular matrix (ECM) remodeling is considered a common factor contributing to progr...

Post photorefractive keratectomy (PRK) infectious keratitis; six-year experience of a tertiary eye hospital.

Mar 14, 2022

As an essential development in the new century, surface ablation procedures have attracted increasing attention. There exists a concern regarding the risk of infectious keratitis. Hence, we aimed to i...

Analysis of Globular Cells in Corneal Nerve Vortex.

Mar 14, 2022

Less was known about globular cells which were a type of dendritic cells (DCs) in cornea. We aimed to investigate the morphological and distribution characteristics of globular cells in corneal vortex...

The involvement of ACO3 protein in diabetic retinopathy through the PI3k/Akt signaling pathway.

Mar 14, 2022

Diabetic retinopathy (DR) is one of the most common complications of diabetic microvascular disease and its pathogenesis is complicated. The PI3k/Akt signaling pathway plays an important role in the a...

Anti-CXCL10 monoclonal antibody therapy protects against the diabetic retinopathy in the mouse model induced by streptozotocin.

Mar 14, 2022

To explore the effect of CXC chemokine CXCL10 in the mice with diabetic retinopathy (DR).DR models were constructed on mice via injection of streptozotocin (STZ). At 3 weeks of STZ, mice were treated ...

Evaluation of UNC OCT Index for Diagnosis of Early Glaucoma.

Mar 14, 2022

To evaluate the diagnostic performance of the University of North Carolina Optical Coherence Tomography (UNC OCT) Index based on Cirrus high-definition optical coherence tomography to discriminate ear...

Ischemic ocular manifestations of giant cell arteritis: A Canadian case series.

Mar 14, 2022

Diagnosing giant cell arteritis (GCA) can be challenging due to the variable clinical presentation and lack of systemic symptoms in approximately 20% of cases, which are termed occult GCA. GCA affects...

Association Between Depression and Severity of Dry Eye Symptoms, Signs, and Inflammatory Markers in the DREAM Study.

Mar 14, 2022

Depression is more prevalent in patients with dry eye disease (DED) than in the general population; however, the association between severity of DED and depression needs further evaluation.To investig...

A compound heterozygous mutation in the S-Antigen Visual Arrestin SAG gene in a Chinese patient with Oguchi type one: a case report.

Mar 07, 2022

Oguchi disease is a rare autosomal recessive form of congenital quiescent night blindness. Oguchi disease has been found to be associated with gene mutations in SAG and GRK1, which are vital factors i...

Disruption of miR-18a Alters Proliferation, Photoreceptor Replacement Kinetics, Inflammatory Signaling, and Microglia/Macrophage Numbers During Retinal Regeneration in Zebrafish.

Mar 07, 2022

In mammals, photoreceptor loss causes permanent blindness, but in zebrafish (Danio rerio), photoreceptor loss reprograms Müller glia to function as stem cells, producing progenitors that regenerate p...

Do limbal relaxing incisions during cataract surgery still have a role?

Mar 07, 2022

Though Limbal Relaxing Incisions (LRI) were used widely to correct pre-existing corneal astigmatism during cataract surgery, they have been replaced recently with the more expensive methods like the u...

Temporal properties of positive and negative defocus on emmetropization.

Mar 07, 2022

Studying the temporal integration of visual signals is crucial to understand how time spent on different visual tasks can affect emmetropization and refractive error development. In this study we asse...

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