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Ophthalmology General

Hyperosmolarity promotes macrophage pyroptosis by driving the glycolytic reprogramming of corneal epithelial cells in dry eye disease.

Jun 05, 2023

Tear film hyperosmolarity plays a core role in the development of dry eye disease (DED) by mediating the disruption of ocular surface homeostasis and triggering inflammation in ocular surface epitheli...

Inner Retinal Thickness and Vasculature in Patients with Reticular Pseudodrusen.

Jun 05, 2023

To investigate retinal layer thickness and vessel density differences between patients with reticular pseudodrusen (RPD) and intermediate dry age-related macular degeneration (iAMD).Participants inclu...

Quantitatively evaluating the relationships between insulin resistance and retinal neurodegeneration with optical coherence tomography in early type 2 diabetes mellitus.

Jun 05, 2023

To quantitatively assess retinal neurodegenerative changes with optical coherence tomography (Cirrus HD-OCT) in type 2 diabetes mellitus (T2DM) patients without diabetic retinopathy (DR), and evaluate...

Macular Retinoschisis from Optic Disc Without a Visible Optic Pit or Advanced Glaucomatous Cupping (No Optic Pit Retinoschisis [NOPIR]).

Jun 05, 2023

To review eyes with peripapillary and macular retinoschisis without a visible optic pit or advanced glaucomatous optic atrophy, or NOPIR (No Optic Pit Retinoschisis) DESIGN: Retrospective multi-center...

Bibliometric Analysis of Ophthalmic Journals.

Jun 05, 2023

The primary vehicle for reporting and testing advances in eye care is refereed ophthalmic journals, which can be characterized using targeted bibliometric analyses.To identify all ophthalmic journals ...

Improved Detection of Dry Age-Related Macular Degeneration from Optical Coherence Tomography Images using Adaptive Window Based Feature Extraction and Weighted Ensemble Based Classification Approach.

May 29, 2023

Dry Age-related macular degeneration (AMD), which affects the older population, can lead to blindness when left untreated. Preventing vision loss in elderly needs early identification. Dry-AMD diagnos...

Corneal gene therapy: Structural and mechanistic understanding.

May 29, 2023

Cornea, a dome-shaped and transparent front part of the eye, affords 2/3rd refraction and barrier functions. Globally, corneal diseases are the leading cause of vision impairment. Loss of corneal func...

A case report: Marfan syndrome with X trisomy and FBN1 and SDHB mutations.

May 29, 2023

Marfan syndrome (MFS) is a rare autosomal dominant connective tissue disorder affecting the cardiovascular, skeletal, and ophthalmic systems. This report aimed to describe a novel genetic background a...

Honey-Related Treatment Strategies in Dry Eye Disease.

May 29, 2023

This systematic review and meta-analysis investigated whether honey-related treatment strategies improve the signs and symptoms of patients with dry eye disease (DED). In March 2023, the following dat...

Developing and validating a questionnaire to assess the symptoms of blepharitis accompanied by dry eye disease.

May 29, 2023

To propose additional items for established dry eye disease (DED) instruments that cover blepharitis-specific signs and symptoms and to determine the association between the clinical findings and subj...

Phacoemulsification with and without iStent: a systematic review and meta-analysis of comparative studies.

May 29, 2023

The iStent (Glaukos Corporation, Laguna Hills, CA, USA) is one of the minimally invasive glaucoma devices. It can be inserted at the time of phacoemulsification or as a stand-alone procedure to lower ...

Individual and Systems-Based Risk Factors for Diabetic Vitrectomy in an Urban Safety-Net Hospital.

May 29, 2023

To identify individual and systems-focused risk factors for pars plana vitrectomy among patients with proliferative diabetic retinopathy in the diverse, urban, safety-net hospital setting.Single-cente...

LncRNA MALAT 1/miR-625-3p/HIF-1α axis regulates the EMT of hypoxia-induced RPE cells by activating NF-κB/snail signaling.

May 22, 2023

The retina may undergo structural and functional damage as a result of hypoxia, which could lead to permanent blindness. As competing endogenous RNAs (ceRNAs), lncRNAs are essential in eye disorders. ...

ABE8e Corrects Pax6-Aniridic Variant in Humanized Mouse ESCs and via LNPs in Ex Vivo Cortical Neurons.

May 22, 2023

Aniridia is a rare congenital vision-loss disease caused by heterozygous variants in the PAX6 gene. There is no vision-saving therapy, but one exciting approach is to use CRISPR/Cas9 to permanently co...

Efficacy of customized corneal crosslinking versus standard corneal crosslinking in patients with progressive keratoconus (C-CROSS study): study protocol for a randomized controlled trial.

May 22, 2023

Keratoconus is a degenerative disorder of the cornea leading to a protrusion and thinning with loss of visual acuity. The only treatment to halt the progression is corneal crosslinking (CXL), which us...

[Influence of tropical endemic limboconjunctivitis on the distribution of astigmatism in a black pediatric population: A hospital-based case-control study].

May 22, 2023

To study the influence of tropical endemic limboconjunctivitis (TELC) on the distribution of astigmatism in a population of black children.We matched two groups of 36 children between the ages of 3 an...

Neurosensory abnormalities and stability of a novel mouse model of dry eye disease.

May 22, 2023

This study aimed to use a mouse model of dry eye disease (DED) induced by topical administration of benzalkonium chloride (BAK) and assess its stability and the presence of neurosensory abnormalities,...

Evaluation of different treatment modalities on the efficacy of hydroxypropyl Guar (HP-Guar) formulation on tear film stability (TFS) in subjects exposed to adverse environmental conditions.

May 22, 2023

The study aimed to assess the efficacy of hydroxypropyl guar (HP) formulation (Systane) to protect tear film parameters under desiccating environment using protection and relief treatment modalities. ...

Five-year outcomes of digital diabetic eye screening in individuals aged 80 and 85 years.

May 22, 2023

To assess the incidence of referable diabetic retinopathy (DR) in patients aged 80 and 85 years to determine whether screening interval can be extended safely in this age group.Patients who were aged ...

Distribution of the cysteinyl leukotriene system components in the human, rat and mouse eye.

May 22, 2023

The cysteinyl leukotrienes (CysLTs) have important functions in the regulation of inflammation and cellular stress. Blocking the CysLT receptors (CysLTRs) with specific antagonists is beneficial again...