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Ophthalmology General

Magnesium acetyltaurate protects against endothelin-1 induced RGC loss by reducing neuroinflammation in Sprague dawley rats.

Mar 12, 2020

Endothelin-1 (ET-1), a potent vasoconstrictor, plays a significant role in the pathophysiology of ocular conditions like glaucoma. Glaucoma is characterized by apoptotic loss of retinal ganglion cells...

Biomechanism of resistance to retinal injury in woodpecker's eyes.

Mar 12, 2020

Retinal injury is the most common ocular impairment associated with shaken baby syndrome (SBS), which could lead to vision loss and blindness. However, a woodpecker does not develop retinal hemorrhage...

A Multimodal Eye Assessment in Psoriatic Arthritis Patients -Psoriasis: Evidence for a Potential Association with Systemic Inflammation.

Mar 12, 2020

Ocular involvement in Psoriatic Arthritis (PsA) patients is mainly associated with uveitis but there remains a paucity of data on dry eye and retinal abnormalities. We aimed to analyze dry eye and sub...

Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein.

Mar 12, 2020

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic neuropeptide hormone. The PACAP receptor PAC1R, which belongs to the class B G-protein-coupled receptors (GPCRs), is a drug ...

[Osteo-odonto-keratoprosthesis: a tooth to regain sight].

Mar 12, 2020

As the leading cause of blindness in the world, corneal diseases are second only to cataracts. However, the epidemiology of corneal disease is complex and includes a wide variety of infectious and inf...

Inter-eye osmolarity differences in patients with symptomatic and non-symptomatic dry eyes.

Mar 12, 2020

To analyze whether inter-eye osmo larity differences were related to dry eye symptomatology.A total of 135 participants were randomly recruited from those who visited in the Optometry Clinic of the Op...

Predictors of Patient Satisfaction After Refractive Lens Exchange With an Extended Depth of Focus IOL.

Mar 12, 2020

To identify independent factors associated with postoperative satisfaction after refractive lens exchange with an extended depth of focus intraocular lens (EDOF IOL).Patients who underwent a refractiv...

Pediatric Diabetic Retinopathy: Experience of a Tertiary Hospital in Oman.

Mar 12, 2020

The aim of this study is to describe the prevalence and clinical profile of pediatric diabetic retinopathy (DR) among Omani diabetic children and adolescents attending a tertiary care hospital.This re...

Prevalence and Severity of Diabetic Retinopathy among Diabetic Patients Presenting to a Tertiary Eye Hospital in Nepal.

Mar 12, 2020

The purpose of the study is to evaluate the prevalence and severity of diabetic retinopathy (DR) among all diabetic patients presenting to a tertiary eye care center in Nepal over a 3-year period.This...

Endocannabinoids in aqueous humour of patients with or without diabetes.

Mar 12, 2020

The primary aim was to determine endocannabinoid (EC) concentrations of 2-arachidonoylglycerol (2-AG), oleoylethanolamine (OEA), palmitoylethanolamine (PEA) and anandamide (AEA) in the aqueous humour ...

Ability of Swept source OCT technology to detect neurodegeneration in patients with type 2 diabetes mellitus without diabetic retinopathy.

Mar 12, 2020

To evaluate neurodegeneration in patients with type 2 Diabetes Mellitus (DM2) without diabetic retinopathy, and to assess the possible role of chronic systemic ischaemia and disease duration in retina...

Association of the Somatostatin Analog Octreotide With Magnetic Nanoparticles for Intraocular Delivery: A Possible Approach for the Treatment of Diabetic Retinopathy.

Mar 12, 2020

The somatostatin analog octreotide (OCT) displays important neuroprotective and anti-angiogenic properties that could make it an interesting candidate to treat diabetic retinopathy (DR). Unfortunately...

Causes of congenital corneal opacities and their management in a tertiary care center.

Mar 12, 2020

To evaluate causes and management of congenital corneal opacities (CCO) diagnosed in a tertiary care eye center and to compare the data with a previous study at the same institution.Computerized medic...

Regression of macular edema with topical brinzolamide and nepafenac alone and identification of a novel gyrate atrophy mutation.

Mar 12, 2020

Gyrate atrophy is a rare metabolic autosomal recessive disorder caused by ornithine aminotransferase enzyme deficiency that leads to characteristic progressive, degenerative chorioretinal findings. Pa...

Corrosion resistance of a Nitinol ocular microstent: Implications on biocompatibility.

Mar 12, 2020

Nitinol is commonly used in medical implants due to its unique thermomechanical properties of shape memory and superelasticity. Free nickel has the potential to induce biological responses that may be...

Watch this space: a systematic review of the use of video-based media as a patient education tool in ophthalmology.

Mar 12, 2020

Effective clinician-patient communication is particularly important in ophthalmology where long-term adherence to treatment is often required. However, in the context of increasingly pressurised clini...

Development and Characterization of a Benchtop Corneal Puncture Injury Model.

Mar 09, 2020

During recent military operations, eye-related injuries have risen in frequency due to increased use of explosive weaponry which often result in corneal puncture injuries. These have one of the poores...

Data-driven modelling and spatial complexity supports heterogeneity-based integrative management for eliminating Simulium neavei-transmitted river blindness.

Mar 09, 2020

Concern is emerging regarding the challenges posed by spatial complexity for modelling and managing the area-wide elimination of parasitic infections. While this has led to calls for applying heteroge...

Deployed ophthalmic workload in support of US and NATO operations in Afghanistan.

Mar 09, 2020

The extent and types of ophthalmic disease and non-battle injury (DNBI) seen by expeditionary ophthalmologists at deployed military medical treatment facilities have not previously been reported. We a...

Analysis of factors leading to lid wiper epitheliopathy.

Mar 09, 2020

Lid wiper epitheliopathy (LWE) has received more attention during the diagnosis and treatment of the dry eye. However, its causes and pathogenesis remain unclear. We aimed to explore the etiology of L...