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Ophthalmology General

Retinal Tissue Bioengineering, Materials and Methods for the Treatment of Glaucoma.

May 12, 2020

Glaucoma, a characteristic type of optic nerve degeneration in the posterior pole of the eye, is a common cause of irreversible vision loss and the second leading cause of blindness worldwide. As an o...

Expression of mRNAs, miRNAs, and lncRNAs in Human Trabecular Meshwork Cells Upon Mechanical Stretch.

May 12, 2020

Intraocular pressure (IOP), the primary risk factor for primary open-angle glaucoma, is determined by resistance to aqueous outflow through the trabecular meshwork (TM). IOP homeostasis relies on TM r...

Comparison of Lamina Cribrosa Morphology in Normal Tension Glaucoma and Autosomal-Dominant Optic Atrophy.

May 12, 2020

To compare lamina cribrosa (LC) morphology in patients with normal tension glaucoma (NTG) and autosomal-dominant optic atrophy (ADOA).This cross-sectional study matched 24 patients diagnosed with ADOA...

Review of Longitudinal Glaucoma Progression: 5 Years after the Shaffer Lecture.

May 12, 2020

In 2013, the senior author delivered the American Academy of Ophthalmology Robert N. Shaffer Lecture entitled "Glaucoma Changes-Reality Bites." This talk focused on describing the longitudinal structu...

Disease Course in Siblings With Stargardt Disease

May 08, 2020

Stargardt disease (STGD1) is an autosomal recessively inherited retinal disease (IRD) caused by variants in the ABCA4 gene, and it is characterized by degeneration of the central retina, leading to de...

Prediction of vestibular schwannoma recurrence using artificial neural network.

Apr 28, 2020

To compare two statistical models, namely logistic regression and artificial neural network (ANN), in prediction of vestibular schwannoma (VS) recurrence.Seven hundred eighty-nine patients with VS dia...

microRNA-216a protects against human retinal microvascular endothelial cell injury in diabetic retinopathy by suppressing the NOS2/JAK/STAT axis.

Apr 28, 2020

Since microRNAs (miRNAs) represent as effective therapeutic targets for diabetic retinopathy (DR), we identified aberrantly expressed miRNAs related to cellular dysfunction in DR and further detected ...

Neurodegeneration in systemic lupus erythematosus: layer by layer retinal study using optical coherence tomography.

Apr 28, 2020

Systemic lupus erythematosus (SLE) is a chronic, autoimmune and multisystemic disease. Recent studies with functional and structural magnetic resonance imaging and cognitive tests report an unexpected...

High Glucose Increases Binding of Lysyl Oxidase to Extracellular Matrix Proteins: Implications for Diabetic Retinopathy.

Apr 28, 2020

To determine whether high glucose (HG) compromises internalization of lysyl oxidase (LOX) through excess binding of LOX with extracellular matrix (ECM) proteins.To determine whether HG promotes bindin...

Acute Hyperglycemia Reverses Neurovascular Coupling During Dark to Light Adaptation in Healthy Subjects on Optical Coherence Tomography Angiography.

Apr 28, 2020

To test the hypothesis that hyperglycemia perturbs neurovascular coupling and compromises retinal vascular response during transition from dark to light in healthy subjects using optical coherence tom...

Mutations in SPATA13/ASEF2 cause primary angle closure glaucoma.

Apr 28, 2020

Current estimates suggest 50% of glaucoma blindness worldwide is caused by primary angle-closure glaucoma (PACG) but the causative gene is not known. We used genetic linkage and whole genome sequencin...

Using 24-hr ocular dimensional profile recorded with a sensing contact lens to identify primary open-angle glaucoma patients with intraocular pressure constantly below the diagnostic threshold.

Apr 28, 2020

To evaluate the use of a 24-hr ocular dimensional profile recorded with a contact lens sensor (CLS) combined with a single tonometric intraocular pressure (IOP) reading to indicate the potential for e...

Aqueous inflammation and ischemia related biomarkers in neovascular glaucoma with stable iris neovascularization.

Apr 28, 2020

To characterize the aqueous levels of inflammation and ischemia related biomarkers in a spectrum of retinal ischemic conditions, including neovascular glaucoma (NVG) with stable iris neovascularizatio...

Clear Lens Extraction in Eyes with Primary Angle Closure and Primary Angle-Closure Glaucoma.

Apr 28, 2020

The crystalline lens plays an important role in the pathophysiology of primary angle closure (PAC) and primary angle-closure glaucoma (PACG). The aging process is associated with a progressive enlarge...

Designing and Validating a Low-Cost Real Time Locating System to Continuously Assess Patient Wait Times.

Apr 28, 2020

Outpatient clinics lack infrastructure to easily measure and understand patient wait times. Our objective was to design a low-cost, portable passive real time locating system within an outpatient clin...

Accuracy of Autorefraction in Children: A Report by the American Academy of Ophthalmology.

Apr 28, 2020

The purpose of this assessment is to evaluate the accuracy of autorefraction compared with cycloplegic retinoscopy in children.Literature searches were last conducted in October 2019 in the PubMed and...

Intense Pulsed Light for Meibomian Gland Disease: A Report by the American Academy of Ophthalmology.

Apr 28, 2020

To review the literature on the efficacy of intense pulsed light (IPL) on the eyelids in the management of meibomian gland disease (MGD) and meibomian gland-related ocular surface disease.A literature...

SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration.

Apr 22, 2020

Retinal degeneration is the leading cause of incurable blindness worldwide and is characterised by progressive loss of light-sensing photoreceptors in the neural retina. SARM1 is known for its role in...

Clinical Accuracy of an Advanced Corneal Topographer with Tear-Film Analysis in Functional and Structural Evaluation of Dry Eye Disease.

Apr 22, 2020

: Dry eye disease (DED) is a common condition that significantly lowers the quality of life. As the disease grows more prevalent, multiple commercial instruments have been developed to measure the ocu...

Amniotic membrane transplantation for managing dry eye and neurotrophic keratitis.

Apr 22, 2020

Neurotrophic keratitis (NK), a degenerative disease caused by damage to the trigeminal nerve, abolishes both tearing and blinking reflexes, thus causing the most severe forms of dry eye disease (DED)....

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