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Ophthalmology General

Association of alcohol intake with incidence and progression of diabetic retinopathy.

May 26, 2020

We examined the longitudinal association of baseline alcohol intake and frequency with the 6-year incidence and progression of diabetic retinopathy (DR) in a population-based cohort of Singaporean Ind...

Long non-coding RNA VIM Antisense RNA 1 (VIM-AS1) sponges microRNA-29 to participate in diabetic retinopathy.

May 26, 2020

Long non-coding RNA (lncRNA) VIM Antisense RNA 1 (VIM-AS1) has been reported to be correlated with type 2 diabetes (T2D) susceptibility, while the roles of this lncRNA in T2D and its complications rem...

Prevalence of Visual Impairment and Coverage of Cataract Surgical Services: Associations with Sex, Disability, and Economic Status in Five Diverse Sites.

May 26, 2020

Prevalence of visual impairment (VI) and access to services can vary significantly across and between different population groups. With renewed focus on universal health coverage and leaving no one be...

Eye Care Utilization in A Community-oriented Mobile Screening Programme for Improving Eye Health in Iran: A Cluster Randomized Trial.

May 26, 2020

To evaluate the effect of a mobile-based screening programme on eye care utilization in Iran.In this cluster randomized community trial, a representative sample of residents aged≥50 years from urba...

Rates of Glaucomatous Structural and Functional Change from a Large Clinical Population: The Duke Glaucoma Registry Study.

May 26, 2020

To investigate rates of structural and functional change in a large clinical population of glaucoma and glaucoma suspect patients.Retrospective cohort.29,548 spectral-domain optical coherence tomograp...

Learning from the past: Mitomycin C use in trabeculectomy and its application to bleb-forming minimally invasive glaucoma surgery.

May 26, 2020

Trabeculectomy has been performed since the mid-1960s and remains the gold standard for glaucoma surgery. Newer surgical options have evolved, collectively referred to as minimally invasive glaucoma s...

Functional Annotations of Single-Nucleotide Polymorphism (SNP)-Based and Gene-Based Genome-Wide Association Studies Show Genes Affecting Keratitis Susceptibility.

May 26, 2020

BACKGROUND Keratitis is a complex condition in humans and is the second most common cause of legal blindness worldwide. MATERIAL AND METHODS To reveal the genomic loci underlying keratitis, we perform...

Atypical Horner's syndrome: frequency, features and aetiology in a paediatric population.

May 26, 2020

Paediatric Horner's syndrome (HS) may present atypically with incomplete or intermittent clinical features, yet could represent sinister pathology including neuroblastoma. We aim to report the frequen...

Central nervous signs, blindness and cerebral vermicosis in free-ranging peregrine falcons (Falco peregrinus) associated with aberrant larval migrations.

May 26, 2020

Four free-ranging peregrine falcons (Falco peregrinus) were submitted with a history of unilateral or bilateral blindness and central nervous signs to a veterinary clinic in Germany. There were no ind...

Efficacy of adjunctive therapy using Vizoovet in improving clinical signs of keratoconjunctivitis sicca in dogs: A pilot study.

May 12, 2020

To assess the clinical safety and efficacy of adjunctive therapy using Vizoovet to ameliorate clinical signs of keratoconjunctivitis sicca (KCS) in dogs.Twenty client-owned dogs.Canine patients diagno...

Pigment Epithelium-derived factor secreted by corneal epithelial cells regulates dendritic cell maturation in dry eye disease.

May 12, 2020

In this study, we quantify Pigment Epithelium-derived Factor (PEDF) secreted by corneal epithelial cells and its immunomodulatory functions in a murine model of dry eye disease (DED).We induced DED in...

Dry anophthalmic socket syndrome - Standardized clinical evaluation of symptoms and signs.

May 12, 2020

To assess symptoms and signs of the dry anophthalmic socket syndrome (DASS) in a standardized manner.87 unilateral anophthalmic patients were evaluated using the Ocular Surface Disease Index (OSDI), t...

When rheumatoid arthritis is mentioned, should only dryness come to mind?

May 12, 2020

To evaluate corneal parameters of rheumatoid arthritis (RA) patients by corneal topography.One hundred two RA patients and 60 control subjects were enrolled. Corneal topography measurements and ophtha...

Loteprednol Etabonate for the Treatment of Dry Eye Disease: A Literature Review.

May 12, 2020

Dry eye disease (DED) is a common ocular condition that can impair vision and may adversely impact quality of life. Due to the inflammatory nature of this disorder, topical corticosteroids are an effe...

Diabetic retinopathy in well-controlled type 2 diabetes: role of glycaemic memory.

May 12, 2020

As diabetic retinopathy (DR) can occur even in well-controlled patients with type 2 diabetes (T2D), our study sought to determine whether it might be related to 'glucose memory 'by evaluating patients...

Correlation of Quantitative Measurements with Diabetic Disease Severity Utilizing Multiple En-Face OCTA Image Averaging.

May 12, 2020

To evaluate the effect of averaging en-face optical coherence tomography angiography (OCTA) images on quantitative measurements of the retinal microvasculature and their correlation to diabetic retino...

Matrix Metalloproteases and Cathepsin D in Human Serum do not Cleave Prolactin to Generate Vasoinhibin.

May 12, 2020

Vasoinhibin is generated in the pituitary gland and in multiple target tissues by proteolytic cleavage of prolactin by matrix metalloproteinases and cathepsin D. A dysregulation of vasoinhibin generat...

Evaluating Signs of Microangiopathy Secondary to Diabetes in Different Areas of the Retina with Swept Source OCTA.

May 12, 2020

The purpose of this study was to compare perfusion parameters of the parafovea with scans outside the parafovea to find an area most susceptible to changes secondary to diabetic retinopathy (DR).Patie...

Vascular changes precede tomographic changes in diabetic eyes without retinopathy and improve artificial intelligence diagnostics.

May 12, 2020

The purpose of this study was to evaluate early vascular and tomographic changes in the retina of diabetic patients using artificial intelligence (AI). The study included 74 age-matched normal eyes, 1...

Prevalence and associated phenotypes of DUSP6, IL17RD and SPRY4 variants in a large Chinese cohort with isolated hypogonadotropic hypogonadism.

May 12, 2020

FGF8-FGFR1 signalling is involved in multiple biological processes, while impairment of this signalling is one of the main reasons for isolated hypogonadotropic hypogonadism (IHH). Recently, several n...