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Ophthalmology General

[Effect of acute insulin therapy on the concentration of vascular endothelial growth factor A (VEGF-A) in the intraocular fluid in an experiment].

Jun 08, 2020

To study the effect of insulin therapy on the concentration of vascular endothelial growth factor A (VEGF-A) in the intraocular fluid of rats with alloxan model of diabetes mellitus.The experiment was...

Performance of deep neural network-based artificial intelligence method in diabetic retinopathy screening: a systematic review and meta-analysis of diagnostic test accuracy.

Jun 08, 2020

Automatic diabetic retinopathy screening system based on neural networks has been used to detect diabetic retinopathy (DR). However, there is no quantitative synthesis of performance of these methods....

[Prevalence of ophthalmic diseases in the population older than 50 years].

Jun 08, 2020

The ageing of population is accompanied by an increase in the frequency of chronic diseases, including ophthalmic. The progression of ophthalmologic disturbances has population specificity and its ana...

Fréchet PDF based Matched Filter Approach for Retinal Blood Vessels Segmentation.

Jun 08, 2020

Retinal pathology diseases such as glaucoma, obesity, diabetes, hypertension etc. have deadliest impact on life of human being today. Retinal blood vessels consist of various significant information w...

A Safe Doppler Ultrasound-Guided Method for Nasolabial Fold Correction With Hyaluronic Acid Filler.

Jun 08, 2020

Injection of hyaluronic acid filler is a common procedure for nasolabial fold correction. However, it poses a risk of vascular compromise, which can result in skin necrosis and blindness.We aimed to e...

Hypomethylation of Notch1 DNA is Associated with the Occurrence of Uveitis.

Jun 04, 2020

Uveitis is a serious intraocular inflammatory disease that can lead to visual impairment even blindness worldwide. Notch signaling can regulate the differentiation of naïve CD4 T cells, influencing t...

Determination of Tear Lipid Film Thickness Based on a Reflected Placido Disk Tear Film Analyzer.

Jun 04, 2020

This study aims at determining the thickness of the tear lipid layer (LL) observed from a placido-disc-based tear film analyzer. We prospectively collected reflections of placido-disk LL images using ...

Ocular Disease Therapeutics: Design and Delivery of Drugs for Diseases of the Eye.

Jun 04, 2020

The ocular drug discovery field has evidenced significant advancement in the past decade. The FDA approvals of Rhopressa, Vyzulta, and Roclatan for glaucoma, Brolucizumab for wet age-related macular d...

A Multi-Center Study of the Prevalence of Dry Eye Disease in Chinese Refractive Surgery Candidates.

Jun 04, 2020

To determine the prevalence of preoperative dry eye disease and evaluate tear film function in refractive surgery candidates in China.In this prospective noninterventional cross-sectional study, refra...

Tilianin Protects Diabetic Retina through the Modulation of Nrf2/TXNIP/NLRP3 Inflammasome Pathways.

Jun 04, 2020

Oxidative stress and inflammation are regarded as prime reasons for the progression and development of diabetic retinopathy. Currently, nuclear factor erythroid-2-related factor 2 (Nrf2), thioredoxin ...

Mitochondrial Ceramide Effects on the Retinal Pigment Epithelium in Diabetes.

Jun 04, 2020

Mitochondrial damage in the cells comprising inner (retinal endothelial cells) and outer (retinal pigment epithelium (RPE)) blood-retinal barriers (BRB) is known to precede the initial BRB breakdown a...

Comprehensive genomic diagnosis of inherited retinal and optical nerve disorders reveals hidden syndromes and personalized therapeutic options.

Jun 04, 2020

In the era of precision medicine, genomic characterization of blind patients is critical. Here, we evaluate the effects of comprehensive genetic analysis on the etiologic diagnosis of potentially here...

Structural assessment of the optic nerve in patients with obstructive sleep apnea syndrome: Case-control study.

Jun 04, 2020

Obstructive sleep apnea syndrome has been identified as a possible risk factor for optic nerve pathology such as glaucoma, nonarteritic ischemic optic neuropathy, and optic disk edema. Accordingly, we...

A pilot study to evaluate the levels of aqueous humor trace elements in open-angle glaucoma.

Jun 04, 2020

Primary open angle glaucoma (POAG) is the most common form of chronic, progressive optic neuropathies characterized by slow degeneration of the retinal ganglion cells and their axons, resulting in vis...

The role of Th17 immunity in chronic ocular surface disorders.

Jun 01, 2020

Th17 cells have been implicated in the pathogenesis of numerous inflammatory and autoimmune conditions. At the ocular surface, Th17 cells have been identified as key effector cells in chronic ocul...

Evaluation of ocular surface disease in elderly patients with glaucoma: expression of matrix metalloproteinase-9 in tears.

Jun 01, 2020

To evaluate the symptoms and signs of ocular surface disease (OSD) and tear-film matrix metalloproteinase-9 (MMP-9) overexpression using point-of-care testing (InflammaDry test) in patients with prima...

Dry Eye and Quantitative and Qualitative Changes of Meibomian Glands in Patients With Pemphigus.

Jun 01, 2020

To evaluate dry eye and quantitative and qualitative changes of meibomian glands with meibography in patients with pemphigus.Twenty left eyes of 20 patients with pemphigus (group 1) and 20 left eyes o...

Efficacy of conbercept combined with panretinal photocoagulation in the treatment of proliferative diabetic retinopathy.

Jun 01, 2020

This prospective clinical study was to compare the effect of panretinal photocoagulation (PRP) associated with intravitreal conbercept injections versus PRP alone in the treatment of proliferative dia...

Intravitreal ranibizumab alone or in combination with panretinal photocoagulation for the treatment of proliferative diabetic retinopathy with coexistent macular edema: long-term outcomes of a prospective study.

Jun 01, 2020

To compare intravitreal ranibizumab as monotherapy or in combination with panretinal photocoagulation (PRP) in patients with proliferative diabetic retinopathy (PDR) and coexistent diabetic macular ed...

Dichloroacetate prevents TGFβ-induced epithelial-mesenchymal transition of retinal pigment epithelial cells.

Jun 01, 2020

Proliferative retinopathies are associated with formation of fibrous epiretinal membranes. At present, there is no pharmacological intervention for the treatment of retinopathies. Cytokines such as TG...