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Ophthalmology General

Evaluation of the genetic association between early-onset primary angle-closure glaucoma and retinitis pigmentosa.

Jun 22, 2020

Primary angle-closure glaucoma (PACG) and retinitis pigmentosa (RP) can co-occur, but the mechanism of their association is not yet established. The purpose of this study was to investigate the differ...

Personalising surgical treatments for glaucoma patients.

Jun 22, 2020

Surgical treatments for glaucoma have relied for decades on traditional filtering surgery such as trabeculectomy and, in more challenging cases, tubes. Antifibrotics were introduced to improve surgica...

Use of Optical Coherence Tomography Retinal Thickness Deviation Map for Hydroxychloroquine Retinopathy Screening.

Jun 22, 2020

To investigate the use of a retinal thickness deviation map generated from swept-source optical coherence tomography (SS-OCT) images for hydroxychloroquine (HCQ) retinopathy screening.Retrospective co...

Fully automated detection, segmentation, and analysis of in vivo RPE single cells.

Jun 22, 2020

To develop a fully automated method of retinal pigmented epithelium (RPE) cells detection, segmentation and analysis based on in vivo cellular resolution images obtained with the transscleral optical ...

Reporting of Race and Ethnicity in the Ophthalmology Literature in 2019.

Jun 22, 2020

The description of racial and ethnic data in human trials is relatively unregulated, leading to potential confusion with and inconsistent reporting of these data.To determine the frequency and use of ...

Cord Blood Platelet Rich Plasma Derivatives for Clinical Applications in Non-transfusion Medicine.

Jun 18, 2020

Cord blood platelet rich plasma (CB-PRP) derivatives have been investigated as potential therapeutic agents for the treatment of diverse conditions including ocular surface disease and skin ulcers. We...

Carboxymethyl Cellulose-Coated Tacrolimus Nonspherical Microcrystals for Improved Therapeutic Efficacy of Dry Eye.

Jun 18, 2020

Dry eye (DE) is a highly prevalent ocular surface disease which affects the quality of life and results in low working efficiency. Frequent instillation is required due to low bioavailability of conve...

A novel botanical formula improves eye fatigue and dry eye: a randomized, double-blind, placebo-controlled study.

Jun 18, 2020

With the frequent use of video display units, eye fatigue is becoming more common globally. An alternative nutritional strategy is needed to prevent the aggravation of eye fatigue symptoms.The objecti...

Association of Cataract Surgery With Risk of Diabetic Retinopathy Among Asian Participants in the Singapore Epidemiology of Eye Diseases Study.

Jun 18, 2020

Cataracts and diabetic retinopathy (DR) are the leading causes of acquired blindness worldwide. Although extraction is the standard treatment option for cataracts, it is also reported to increase the ...

Discordant vascular parameter measurements in diabetic and non-diabetic eyes detected by different optical coherence tomography angiography devices.

Jun 18, 2020

To compare quantitative changes in macular parameters in diabetic patients detected by two optical coherence tomography angiography (OCTA) instruments.80 phakic eyes were classified as no diabetes, di...

Longitudinal Angiographic Evidence that Intraretinal Microvascular Abnormalities Can Evolve into Neovascularization.

Jun 18, 2020

The hallmark of proliferative diabetic retinopathy (PDR) is retinal neovascularization (NV). Tortuous intraretinal vascular segments known as intraretinal microvascular abnormalities (IRMAs) are a kno...

Next generation sequencing using phenotype-based panels for genetic testing in inherited retinal diseases.

Jun 18, 2020

Diagnostic next generation sequencing (NGS) services for patients with inherited retinal diseases (IRD) traditionally use gene panel based approaches, which have cost and resource implications. Phenot...

Phase 3, Randomized, 20-Month Study of Bimatoprost Implant in Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 1).

Jun 18, 2020

To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10- and 15-μg bimatoprost implant in subjects with open-angle glaucoma (OAG) and ocular hypertension (OHT) after initial and...

Monoclonal Antibody-Based Treatments for Neuromyelitis Optica Spectrum Disorders: From Bench to Bedside.

Jun 15, 2020

Neuromyelitis optica (NMO)/NMO spectrum disorder (NMOSD) is a chronic, recurrent, antibody-mediated, inflammatory demyelinating disease of the central nervous system, characterized by optic neuritis a...

Autologous serum eye drops improve tear production, both lachrymal flow and stability tests and conjunctival impression cytology with transfer in dry eye disease.

Jun 15, 2020

Autologous serum eye drops, produced by separation of liquid and cellular components of the patient's blood, contain biological nutrients present in natural tears. The aim of this study was to analyse...

The effect of astaxanthin on inflammation in hyperosmolarity of experimental dry eye model in vitro and in vivo.

Jun 15, 2020

Hyperosmolarity is pro-inflammatory stress to the ocular surface epithelium for dry eye disease (DED). Astaxanthin (AST) is a kind of carotene, which exists in seafood and has been proved to inhibit i...

Blepharospasm, dry eye and extractable nuclear antigen antibodies.

Jun 15, 2020

To study whether there is an association between benign essential blepharospasm and Sjögren's syndrome by analyzing the presence of antibodies to extractable nuclear antigens in this population.Seven...

Destruction of the blood-retina barrier in diabetic retinopathy depends on angiotensin-converting enzyme-mediated TGF-β1/Smad signaling pathway activation.

Jun 15, 2020

Diabetes mellitus (DM) is a systemic, chronic metabolic disease that is related to heredity and autoimmunity and is often accompanied by complications of retinopathy. However, the causative mechanism ...

Artificial intelligence for anterior segment diseases: Emerging applications in ophthalmology.

Jun 15, 2020

With the advancement of computational power, refinement of learning algorithms and architectures, and availability of big data, artificial intelligence (AI) technology, particularly with machine learn...

Omidenepag Isopropyl Versus Latanoprost in Primary Open-angle Glaucoma and Ocular Hypertension: ThePhase 3 AYAME Study.

Jun 15, 2020

To evaluate the efficacy and safety of omidenepag isopropyl (OMDI), a selective, non-prostaglandin, prostanoid EP2 receptor agonist, in Japanese patients with primary open-angle glaucoma (POAG) or ocu...