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Ophthalmology General

Zinc oxide nanoparticles from Cyperus rotundus attenuates diabetic retinopathy by inhibiting NLRP3 inflammasome activation in STZ-induced diabetic rats.

Jul 23, 2020

Diabetic retinopathy (DRP) is a retinal disease caused by diabetes mellitus, which is categorized by microvascular lesions present in the retina such as vascular leakage, vascular proliferation, and r...

Unique molecular signatures of microRNAs in ocular fluids and plasma in diabetic retinopathy.

Jul 23, 2020

The main objective of this pilot study was to identify circulatory microRNAs in aqueous or plasma that were reflecting changes in vitreous of diabetic retinopathy patients. Aqueous, vitreous and plasm...

Retinal proteomics of experimental glaucoma model reveal intraocular pressure-induced mediators of neurodegenerative changes.

Jul 23, 2020

Current evidence suggests that exposure to chronically induced intraocular pressure (IOP) leads to neurodegenerative changes in the inner retina. This study aimed to determine retinal proteomic altera...

Comparison of peripapillary Capillary Density in Glaucoma Patients of African and European descent.

Jul 23, 2020

To evaluate racial differences in optic nerve head peripapillary capillary density measured by optical coherence tomography angiography (OCTA) in patients with open-angle glaucoma.Observational, cross...

Glaucoma after ocular surgery or trauma: the role of infiltrating monocytes and their response to cytokine inhibitors.

Jul 23, 2020

Glaucoma is a frequent and devastating long-term complication following ocular trauma, including corneal surgery, open globe injury, chemical burn, infection, etc. Post-event inflammation and neurogli...

Filtering-associated Endophthalmitis Following Trabeculectomy or Tube-shunt Implant.

Jul 23, 2020

To determine the rate, clinical features, and outcomes of filtering-associated endophthalmitis in eyes that underwent trabeculectomy or tube-shunt implantation.Retrospective database study with select...

Return to the Operating Room after Vitrectomy for Vitreous Opacities: IRIS® Registry Analysis.

Jul 23, 2020

To investigate the rate of return to the operating room after vitrectomy surgery for vitreous opacities DESIGN: A retrospective registry cohort PARTICIPANTS: Individuals receiving care in ophthalmolog...

Stakeholder-Engaged Derivation of Patient-Informed Value Elements.

Jul 20, 2020

Our objective was to identify patient-informed value elements that can be used to make value assessment more patient centered.Mixed methods were used iteratively to collect and integrate qualitative a...

Validation of WINROP (online prediction model) to identify severe retinopathy of prematurity (ROP) in an Australian preterm population: a retrospective study.

Jul 20, 2020

Retinopathy of prematurity (ROP) is the most common disease leading to blindness in extreme preterm infants. Current screening guidelines recommend frequent eye examinations. There is a dearth of trai...

Periorbital botulinum toxin A improves photophobia and sensations of dryness in patients without migraine: Case series of four patients.

Jul 20, 2020

Individuals receiving botulinum toxin A (BoNT-A) injections in the head and neck for migraine treatment have reported decreases in photophobia and sensations of dryness, independent of ocular surface ...

Lacrimal Gland Myoepithelial Cells Are Altered in a Mouse Model of Dry Eye Disease.

Jul 20, 2020

The purpose of this study was to determine the pathogenic changes that occur in myoepithelial cells (MECs) from lacrimal glands of a mouse model of Sjogren's syndrome. MECs were cultured from lacrimal...

Prospects of Temperature Management in Vitreoretinal Surgery.

Jul 20, 2020

Currently, there are no clear recommendations about the safety of certain temperature conditions for intraocular structures during vitreoretinal surgery; instructions on the safe rate of rewarming of ...

Associations between alcohol intake and diabetic retinopathy risk: a systematic review and meta-analysis.

Jul 20, 2020

Some previous studies have reported inconsistent results on the association between alcohol intake and diabetic retinopathy (DR) risk. This study aimed to evaluate the potential effects of alcohol int...

Effects of Induced Astigmatism on Spectral Domain-OCT Angiography Quantitative Metrics.

Jul 20, 2020

To analyze the effect of induced astigmatism on en-face spectral-domain optical coherence tomography angiography (SD-OCTA) quantitative metrics.Prospective Cross-Over Study METHODS: Normal eyes withou...

Photopic negative response using a handheld mini-ganzfeld stimulator in healthy adults: normative values, intra- and inter-session variability.

Jul 20, 2020

To determine normative values, intra- and inter-session variability for a range of parameters derived from the photopic negative response (PhNR) using a handheld mini-Ganzfeld stimulator in healthy no...

Anti-vascular endothelial growth factor in neovascular age-related macular degeneration - a systematic review of the impact of anti-VEGF on patient outcomes and healthcare systems.

Jul 20, 2020

Systematically review the evidence describing the impact of anti-vascular endothelial growth factor (anti-VEGF) therapy on neovascular age-related macular degeneration (nAMD) patient outcomes and heal...

Meibomian gland dysfunction is the primary determinant of dry eye symptoms: Analysis of 2346 patients.

Jul 20, 2020

To determine relative contributions of various ocular surface clinical signs and predisposing factors to the magnitude of dry eye symptoms.Clinical audit data were prospectively collected for newly re...

Central retinal artery occlusion as a post-transfusion complication of red blood cells.

Jul 16, 2020

A 32-year-old woman presented with a history of uterine myomatosis and repeated bleeding for 6 months. This produced a haemoglobin concentration of 6.5 g/dL, with a requirement for a red blood cell t...

MicroRNA-148a-3p alleviates high glucose-induced diabetic retinopathy by targeting TGFB2 and FGF2.

Jul 16, 2020

Diabetic retinopathy (DR), a common complication of type 1 or type 2 diabetes mellitus, has become the leading cause of blindness among adults in working age. The dysregulation of microRNA has been re...

Cataract Surgery Destabilises Temporary the Tear Film of the Ocular Surface.

Jul 16, 2020

Symptoms due to dry eye in the form of keratoconjunctivitis sicca (KCS) are often seen after cataract surgery. We investigated the influence of cataract surgery on tear film stability on the ocular su...