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Ophthalmology General

Glaucoma causes redox imbalance in the primary visual cortex by modulating NADPH oxidase-4, iNOS, and Nrf2 pathway in a rat experimental model.

Sep 10, 2020

The aim of this study was to elucidate the intracellular sources of oxidant species, the antioxidant response as well as the main signaling pathways involved in the regulation of the redox balance in ...

Utility of 10-2 Visual Field Testing in Glaucoma Patients with Early 24-2 Visual Field Loss.

Sep 10, 2020

To determine whether the 10-2 test of the Humphrey Field Analyzer detected a higher proportion of abnormal visual fields compared to the 24-2 test in the central 10° in patients with early visual fie...

Breastfeeding and Maternal Age-Related Cataract in the U.S. Population.

Sep 07, 2020

An estimated 38 million and 50 million individuals will have cataract in the U.S. alone by 2030 and 2050, respectively. Breastfeeding is known to improve a number of health outcomes in both breastfed ...

Biotin Regulates Colonization and Growth of Candida albicans in the Catheter Lumen During Nutrient Infusions.

Sep 07, 2020

Bacterial and fungal catheter-related bloodstream infections (CRBSI) cause high fever and blindness due to fungal endophthalmitis. Candidal CRBSI have a particularly high mortality rate and needs at...

Comprehensive profiling of Asian and Caucasian meibomian gland secretions reveals similar lipidomic signatures regardless of ethnicity.

Sep 07, 2020

Meibum-a lipid secretion that is produced by Meibomian glands (MG) in a process termed meibogenesis-plays a critical role in ocular surface physiology. Abnormalities in the chemical composition of mei...

hADSCs derived extracellular vesicles inhibit NLRP3inflammasome activation and dry eye.

Sep 07, 2020

The present study was set out to address the therapeutic efficacy of human adipose tissue stem cells derived extracellular vesicles (hADSC-Evs) in a mouse model of dry eye disease and to investigate t...

Enhanced closed eye neutrophil degranulation in dry eye disease.

Sep 07, 2020

Closed eye neutrophils have demonstrated increased prevalence in dry eye disease, but the phenotype and extent of activation of these cells has yet to be described.12 normal subjects and 12 subjects w...

Comparison of 2-Year Outcomes between Intravitreal Ranibizumab and Intravitreal Aflibercept for Diabetic Macular Edema with "Treat-and-Extend" Regimen-Its Usefulness and Problems.

Sep 07, 2020

To compare the effectiveness of intravitreal ranibizumab (IVR) and intravitreal aflibercept (IVA) performed with the treat-and-extend (TAE) regimen on eyes with diabetic macular edema (DME).This is a ...

Systemic alterations in leukocyte subsets and the protective role of NKT cells in the mouse model of diabetic retinopathy.

Sep 07, 2020

The involvement of leukocytes in the pathophysiology of DR has mostly examined the role of monocytes and neutrophils with little emphasis on other immune cell types. In this study, we determined the s...

Fufang Xueshuantong alleviates diabetic retinopathy by activating the PPAR signalling pathway and complement and coagulation cascades.

Sep 07, 2020

Fufang Xueshuantong (FXST) is a traditional Chinese patent medicine composed of Panax notoginseng (Burkill) F.H.Chen (Araliaceae), Salvia miltiorrhiza Bunge (Lamiaceae), Astragalus propinquus Schischk...

Lower Eyelid Horizontal Tightening in Prostaglandin Associated Periorbitopathy.

Sep 07, 2020

To determine the effect of chronic topical use of prostaglandin analogs for glaucoma on lower eyelid tension.A prospective case-control study was performed. Lower eyelid tension was measured in a grou...

An Evaluation Using Colored Doppler Ultrasonography of Central Retinal Artery Hemodynamics in the Healthy Eye in Individuals With Late Monocular Blindness.

Sep 07, 2020

Structural and functional changes occur in the brain after vision losses. The purpose of the present study was to investigate central retinal artery (CRA) hemodynamics in the healthy eye of individual...

Retinal changes in Alzheimer's disease- integrated prospects of imaging, functional and molecular advances.

Sep 07, 2020

Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically characterised by cognitive deficits that gradually worsen over time. There is, at present, no established ...

Using the West Midlands CONCERT to characterise regional incidence of acute-onset post cataract surgery endophthalmitis.

Sep 07, 2020

Whilst research and innovation is embedded within the UK's National Health Service (NHS) constitution, Doctors-in-training have little opportunity to contribute to designing, leading and recruiting in...

Cost-effectiveness of Autonomous Point-of-Care Diabetic Retinopathy Screening for Pediatric Patients With Diabetes.

Sep 07, 2020

Screening for diabetic retinopathy is recommended for children with type 1 diabetes (T1D) and type 2 diabetes (T2D), yet screening rates remain low. Point-of-care diabetic retinopathy screening using ...

Glaucoma and Intraocular Pressure

Sep 04, 2020

Intraocular pressure (IOP) refers to the fluid pressure inside the eye and is an essential aspect in the evaluation of patients at risk of glaucoma. But the prevalence of glaucoma associated with the ...

Application of graphene nanowalls in an intraocular pressure sensor.

Sep 03, 2020

As the second leading cause of blindness in the world, glaucoma is mainly caused by persistent high intraocular pressure (IOP) that compresses the optic nerve and causes permanent damage. Noninvasive ...

Diagnostic Markers in Ocular Sarcoidosis in A High TB Endemic Population - A Multicentre Study.

Sep 03, 2020

To look at markers to differentiate ocular sarcoidosis from ocular tuberculosis in a high TB endemic population.Retrospective multicenter study involving seven tertiary eyecare centers in India betwee...

Diabetes Induced Alterations in Murine Vitreous Proteome Are Mitigated by IL-6 Trans-Signaling Inhibition.

Sep 03, 2020

Diabetic retinopathy (DR) is a microvascular complication caused by prolonged hyperglycemia and characterized by leaky retinal vasculature and ischemia-induced angiogenesis. Vitreous humor is a gel-li...

Automatic Grading of Retinal Blood Vessel in Deep Retinal Image Diagnosis.

Sep 03, 2020

Automatic grading of retinal blood vessels from fundus image can be a useful tool for diagnosis, planning and treatment of eye. Automatic diagnosis of retinal images for early detection of glaucoma, s...

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